Reproductive technologies and the risk of congenital heart defects

Abstract

Assisted reproductive technology (ART) has become widespread, accounting for ∼2% of all births worldwide, with a similar proportion in Japan. Our goal was to determine whether ART is associated with an increased risk of congenital heart defect (CHD). The study subjects were 2716 pregnant women (2317 in a spontaneous conception [SC] group and 399 in an assisted conception [AC] group). Of patients in the AC group, 142 were treated with ovulation-inducing agents (OIAs), 56 with artificial insemination by the husband (AIH), 159 with in vitro fertilization (IVF), and 42 with intracytoplasmic sperm injection (ICSI). CHD screening on the fetus or newborn was performed using two-dimensional echocardiography. Severe CHD was defined as requiring surgical treatment, or leading to death within one year. There were 2746 births (one of 31 twins was a still birth), 410 resulted from AC and within this group, 111 cases of CHD were found (AC group, 17 [4.1%]; SC group, 94 [4.0%]). Five cases of severe CHD were found in the AC group and 19 in the SC group, with no significant difference between the groups (p = 0.892). In conclusion, there was no evidence of increased CHD risk associated with ART treatment.

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

“…Notably, birth defects were a problem, and the major congenital malformations in newborns conceived by ART were not significantly different from those of newborns who were spontaneously conceived (Henningsen et al, 2018). However, there were significant differences in some birth defects, especially congenital heart defects, among newborns conceived by ART compared with those spontaneously conceived (Giorgione et al, 2018; Hoorsan et al, 2017; Iwashima, Ishikawa, & Itoh, 2017; Patil et al, 2018). In our retrospective study, there was a case of cardiopulmonary hypoplasia in the NSMR <4% group and a case of congenital ventricular deficiency in the NSMR ≥4% group.…”

Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta‐analysis

“…The PRISMA statement was used for reporting the Methods, Results and Discussion sections of the current review. Extracted data from all included articles are shown in Table S1.…”

Problems of Children's Disability in Modern Russia

“…Как свидетельствуют данные литературы, у детей, родившихся в результате экстракорпорального оплодотворения (ЭКО), на 30-40% чаще, чем в общей по-2 Доступно на: http://www.zakonprost.ru/content/base/part/1053068 ОРГАНИЗАЦИЯ ЗДРАВООХРАНЕНИЯ ВЕСТНИК РАМН /2017/ 72 (4) пуляции, регистрируются «большие» пороки развития [21][22][23][24][25][26]. В Китае при обследовании около 100 000 детей, рожденных с помощью ЭКО, были выявлены высокие риски врожденных аномалий системы кровообращения, нервной, костно-мышечной, пищеварительной и мочеполовой систем.…”