Repressive effects of red bean, Phaseolus angularis, extracts on obesity of mouse induced with high-fat diet via downregulation of adipocyte differentiation and modulating lipid metabolism

Park, Young Mi; Kim, Jee In; Seo, Dong Han; Seo, Joo Hee; Lim, Jae-Hwan; Lee, Jong Eun; Choi, Je‐Yong; Seo, Eul-Won

doi:10.1007/s10068-018-0421-2

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Moringa oleifera Lamarck is well known for its diverse medicinal and nutritional properties which belongs to the family Moringaceae (Anwar et al, 2007). The plant leaves are commonly used to treat cancer, type 2 diabetes mellitus, downregulation of adipocyte differentiation, and cardiovascular diseases (Park et al, 2018; Verma et al, 2009). Beyond its role in the regulation of blood lipids, the anti‐atherogenic, anti‐inflammatory, and anti‐oxidative actions of M. oleifera have also been used in the synthesis of silver nanoparticles for investigating the anti‐cancer properties (Vasanth et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Anti‐adipogenic β‐sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression

Vasanth

Minakshi

Karthick

et al. 2022

Journal of Food Biochemistry

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Triterpenes and phytosterols enriched herbal formulations are known for glucose regulation and lipid metabolism. In this study, triterpenes and phytosterols from Moringa oleifera stem bark have been tested for their role in adipocyte differentiation. Chromatographic analysis revealed a wide range of phenolics, highlighting the presence of flavonoids (kaempferol, quercetin, and rutin), terpenoids (lupeol), and phytosterol (stigmasterol, β‐sitosterol). Lupeol and β‐sitosterol reduced cell viability in a dose‐dependent manner showcasing increased G1 phase cell accumulation while reducing other cell cycle phases (S and G2/M) and significant lowering of intracellular lipid accumulation. Additionally, lupeol (35.37% at 32 μM) and β‐sitosterol (42.97% at 16 μM) inhibited reactive oxygen species generation and increased glucose uptake in adipocytes. Collectively, our results indicate that lupeol and β‐sitosterol efficaciously attenuated adipogenesis via a controlled cell cycle progression and enhanced glucose uptake in adipocytes. Practical applications Active components of Moringa oleifera effectively regulate adipocyte differentation suggest that it can be good medicial supllement for control of obesity.

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Section: Introductionmentioning

confidence: 99%

Anti‐adipogenic β‐sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression

Vasanth

Minakshi

Karthick

et al. 2022

Journal of Food Biochemistry

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“…The parameters of U , P , and E indicate energy, polarization, and electric field, respectively. It is obvious that the local derivate d U /d P shows a negative slope at a specific range, and thus the negative capacitance behavior can be observed in this versatile memory …”

mentioning

confidence: 93%

Experimental Observation of Negative Capacitance Switching Behavior in One‐Transistor Ferroelectric Versatile Memory

Cheng

Chiu

Liou

2017

Physica Rapid Research Ltrs

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In this work, we investigated the negative capacitance behavior of novel ferroelectric versatile memory with low-voltage-driven and fast ferroelectric switching. The combined storage mechanism strengthened the stability of ferroelectric polarization by interface aligned dipoles. The simulation results of first principle calculation indicated that the monoclinic-like orthorhombic phase of ferroelectric hafnium oxide facilitated the occurrence of S-shaped negative capacitance behavior. Furthermore, the control of phase transition may affect ferroelectric property and negative capacitance effect during program and erase states.The ferroelectric memory using CMOS-compatible hafniumoxide-based materials [1][2][3][4][5][6][7][8][9][10] is the potential candidate among emerging memories because of its fast switching speed, long endurance and low voltage operation. Recently, the ferroelectric transistor also has made significant progress due to negative capacitance effect. [11,12] The negative capacitance effect in ferroelectric dielectrics has been proposed, [11][12][13][14][15][16][17] but experimental observation based on ferroelectric characteristics and physical mechanism model is less revealed in ferroelectric transistor memory device. Our previous study reported a versatile ferroelectric memory, [18][19][20] which is a promising candidate for next-generation dynamic random access memory (DRAM) or nonvolatile memory (NVM). To improve the stability of ferroelectric polarization, we choose a top charge-trapped zirconium-silicon oxide (ZrSiO) because of its large band gap to strengthen the spontaneous polarization of hafniumzirconium oxide (HfZrO) during memory switching operation. According to previous study on polarization degradation, the migration of charged oxygen vacancies through electric field is key factor in polarization fatigue, especially for those along the polarization axis. [4][5][6] Thus, oxygen vacancy may impact fast ferroelecrtric switching. To prevent this issue, we adopt a chargetrapping approach forming the interface aligned dipoles between top ZrSiO trapping layer and bottom HfZrO ferroelectric layer to reduce the migration effect of charged oxygen vacancies. [18] After a series of trials, we successfully demonstrated that the memory property of ferroelectric memory can be effectively improved by the combined storage mechanism of charge-trapping and ferroelectric domain. In this work, we further investigated ferroelectric negative capacitance behavior and underlying physical mechanism of ferroelectric versatile memory, which is very important for energyefficient switching of next-generation memory technology.Experiments: The fabrication procedure of memory device is simply described as follows. First, a 3.6-nm SiO 2 grown by dry oxidation process of vertical furnace was used as a bottombuffered oxide. Then the 21-nm-thick HZO ferroelectric layer and 7.5-nm-thick ZSO trapping layer were deposited by a evaporation and a sputter system, respectively. To make a performance comparison, a control ferr...

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Challenges and opportunities in developing low glycemic index foods with white kidney bean α-amylase inhibitor

Liu,

Gu,

Waleed

et al. 2024

Trends in Food Science & Technology

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Repressive effects of red bean, Phaseolus angularis, extracts on obesity of mouse induced with high-fat diet via downregulation of adipocyte differentiation and modulating lipid metabolism

Cited by 3 publications

References 36 publications

Anti‐adipogenic β‐sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression

Anti‐adipogenic β‐sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression

Experimental Observation of Negative Capacitance Switching Behavior in One‐Transistor Ferroelectric Versatile Memory

Challenges and opportunities in developing low glycemic index foods with white kidney bean α-amylase inhibitor

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