Report of the committee on the genetic constitution of chromosome 2

Povey, Sue; Falk, Catherine T.

doi:10.1159/000132782

Cited by 29 publications

(4 citation statements)

References 11 publications

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“…They have been named according to the number of repeat units that they contain. The genetic 49 map of human chromosome 2, in which the apoB gene is located, is relatively well established, with more than 160 loci [21]. It appears to form a continuous linkage group in which no recombination hotspot areas have been reported [22].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease

Heliö

Palotie

Tötterman

et al. 1992

Journal of Internal Medicine

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Previous studies have suggested that some apolipoprotein B (apoB) 3' variable number of tandem repeats (3'VNTR) locus alleles are associated with coronary artery disease (CAD). We examined the possible association between the apoB 3'VNTR alleles and CAD in 387 Finnish subjects. Using the polymerase chain reaction and polyacrylamide gel electrophoresis, the 3'VNTR genotype was determined in 187 individuals with severe CAD confirmed by coronary angiography (patients), in 121 individuals with normal coronary angiograms (controls), and in 79 apparently healthy subjects (normals). In contrast to previous reports from other populations, the larger apoB 3'VNTR alleles were not significantly more frequent among CAD patients than among controls or normals. In addition, there was no significant association between the 3'VNTR alleles and serum lipid levels in this Finnish population.

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Section: Introductionmentioning

confidence: 99%

Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease

Heliö

Palotie

Tötterman

et al. 1992

Journal of Internal Medicine

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“…These assignments have been defined by linkage analysis. In fact, multipoint mapping suggested that the most likely order was COL3Al-(ELN-FN)-COL6A3 with the orientation of ELN-FN1 not reliably fixed (reviewed in [25]. It is worth mentioning the fact that the FN genes as well as the two integrin a subunit genes, a 4 and av, that function as specific FN receptors, map to the same region of chromosome 2.…”

Section: Resultsmentioning

confidence: 99%

Mapping of the human VLA‐α4 gene to chromosome 2q31‐q32

et al. 1992

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The integrin VLA-4 (alpha 4: beta 1; CD49d/CD29) is involved in both cellular adhesion to extracellular matrix and cell-cell interactions. We have determined that the human gene coding for VLA-alpha 4 is located on the long arm of chromosome 2 by using fluorescence in situ hybridization. The VLA-alpha 4 gene has been more precisely mapped to the 2q31-q32 region after GTG banding (G-bands by trypsin using Giemsa). These data suggest that the VLA-4 gene belongs to the COL3A1-(ELN-FN)-COL6A3 linkage group and establishes a potential genetic relationship between the alpha 4 and alpha v integrin subunits.

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“…Another gene which appears closely linked to Neb in the mouse is argininosuccinate synthe tase (Ass-1; Jackson et al, 1990). Interestingly, the human homolog of this gene is located on chromosome 9 while one of its pseudo-genes (ASSP1) has been mapped to the centromeric region of human chromosome 2 (Povey and Falk, 1989).…”

Section: Resultsmentioning

confidence: 99%

Mapping of the gene coding for the muscle protein nebulin <i>(Neb</i>) to the proximal region of mouse Chromosome 2

Schurr

Skamene²,

Gros³

1991

Cytogenet Genome Res

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Using five different series of recombinant inbred (RI) strains, we have mapped the gene encoding nebulin, a muscle-specific protein. The strain distribution pattern of Neb-specific RFLPs segregating in the RI strains showed significant concordance with those of Pmv-7 and Hc, two loci previously located to proximal mouse Chromosome 2. The gene order, intergene distances, and confidence intervals were determined according to standard maximum likelihood estimates as: centromere-Hc-5.4 cM (1.4 cM-15.4 cM; 95% confidence interval)- Neb-3.6 cM (1.5–6.7 cM)-Pmv-7.

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Report of the committee on the genetic constitution of chromosome 2

Cited by 29 publications

References 11 publications

Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease

Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease

Mapping of the human VLA‐α4 gene to chromosome 2q31‐q32

Mapping of the gene coding for the muscle protein nebulin <i>(Neb</i>) to the proximal region of mouse Chromosome 2

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