Report of the committee on the genetic constitution of chromosome 1

Hamerton, J.L.; Povey, Sue; Morton, N.E.

doi:10.1159/000132001

Cited by 25 publications

(4 citation statements)

References 11 publications

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“…Therefore, the translocations can probably serve as sign posts to transcriptionally active chromosomal domains. It seems worth mentioning that the gene for parotid gland alphaamylase is located at chromosome Nr lp21 (Hamerton et al, 1984), close to a recipient site described by Stenman et al (1984) (Fig. 5).…”

Section: Discussionsupporting

confidence: 51%

Structural rearrangements of chromosome Nr 8 involving 8q12?a primary event in pleomorphic ademona of the parotid gland

et al. 1987

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Nine pleomorphic adenomas of the human parotid gland were investigated. Within this series the group of cases having clonal aberrations of chromosome Nr 8 predominates. The occurrence of cases with trisomy-8 and cases with structural rearrangements involving a breakpoint in 8q11-8q13 allows a further subdivision of this group of tumors. Our special interest in this paper is devoted to the latter group. The hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12. The translocations to different recipient chromosomes may serve as sign posts to transcriptionally active chromosomal domains in the salivary gland.

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Section: Discussionsupporting

confidence: 51%

Structural rearrangements of chromosome Nr 8 involving 8q12?a primary event in pleomorphic ademona of the parotid gland

et al. 1987

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“…Chromosome 1 is now the best mapped human autosome, with 30 loci confidently assigned and an additional 18 provisionally assigned (Hamerton, Povey k Morton, 1984). With the advent of new recombinant DNA techniques the list of localized genes is growing rapidly.…”

Section: Introductionmentioning

confidence: 99%

A revised map of chromosome 1

Sherman

King

Robson

et al. 1984

Annals of Human Genetics

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The genetic map of chromosome 1 reported by Keats, Morton & Rao (1981) has been updated using recent recombination data and regional assignments from the Galton Laboratory (King, 1982a) and from the current literature. A maximum likelihood mapping technique using pairwise recombination data without a chiasma map was developed, based on the principles of Rao et al. (1979) and Keats et al. (1981). The development of this new method was found to be necessary when inconsistencies were encountered using a method which combines recombination data and physical data through the chiasma map. These inconsistencies could be due to appreciable chiasma movement, incorrect physical assignments or technical and biological variation in lod scores.

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“…This is not signifi cantly higher than the sexless estimate. Interestingly, however, the maximum occurs at a male recombina tion rate nearly twice the female rate.Recent linkage maps of chromosome 1 (Hamerton et al 1984;Wedd, 1984) place PGM 1 and Fy at slight ly over 50 cM apart, suggesting that the prior proba bility that NGFB would show linkage with either PGMI or Fy is very high. Consequently, these results represent strong evidence that NGFB is closer on the linkage map to Fy than it is to PGM1, and.…”

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confidence: 99%

“…Although the NGFB locus has been mapped cytologically to the chromosomal segment between PGM I and AMY2 (Miinke et al, 1984), NGFB not only shows no ev idence of linkage with PGM1 but the data are suf ficient to exclude linkage below 16% recombination. The recent linkage maps of chromosome 1 (Hamerton et al 1984;Wedd, 1984) also show a relative difference in the "distances" on the cytological and linkage maps for the region just proximal to PGM!. AMY I and AMY2 have been mapped to lp21, just proximal to PGM1 but show >30% recombination with PGMI.…”

mentioning

confidence: 99%