Linkage relationships of the gene for the β subunit of nerve growth factor (<i>NGFB</i>) with other chromosome 1 marker loci

Report of the committee on the genetic constitution of chromosomes 1 and 2

“…An alternative explanation as suggested by Darby et al (1985a) would be a region of high frequency of recombination within lp22.1 and between PGM1 and NGFB. This would fit quite well with the chiasma map (Hulten et al 1982;Laurie and Hulten 1985).…”

“…Further ijo situ experiments on lymphocytes from the carrier of a balanced translocation have localized NGFB to 1p22.1 (Muenke et al HGM8). Restriction fragment length polymorphisms of NGFB have been found (Breakefield et al 1984, Darby et al 1985 and have been used to show absence of close linkage between NGFB and disseminated neurofibromatosis NF1 (Darby et al 1985a;Darby et al 1985a + b). Further data presented in these proceedings have virtually excluded NF1 from the whole of lp (Darby et al HGM8).…”

Linkage Analyses of Multiple Endocrine Neoplasia, Type 2A (MEN-2A) with 20 DNA Polymorphisms: 5&percnt; of the Genome Excluded

“…The two Amylase loci are closely linked, both being on the short arm of chromosome I (in band lp21), and are probably within 20 cM of NGFB [Darby et al, 1985a, Povey et al, 1985. We now have negative lod scores for MEN2 with four loci that span the proximal short arm of chromosome 1: PGM1, NGFB, AMY1 and AMY2, and FY.…”