Report of the committee on the genetic constitution of chromosome 11

Isolation and mapping of 88 new RFLP markers on human chromosome 8

“…The deleted region of each hybrid is delineated by the gap in the vertical bold line. Probable breakpoint localizations, in cases where direct cytogenetic analysis was not definitive, have been determined by their relationship to the map positions of other genes and markers Junien and McBride 1989). DNAs from these 15 cell lines were analyzed by Southern blotting, with the cosmid clones carrying RFLP markers as probes.…”

A WAGR region gene between PAX-6 and FSHB expressed in fetal brain

“…The proximal boundary of the C.L. deletion is more centromeric than those in GM8785, GM6803, GM7736 and other WAGR/ AGR patients with mental retardation (Gessler et al 1989;Gessler and Bruns l989b;Junien and McBride, 1989) but it does not extend as far on the telomeric side (Fig. 2).…”

“…2). The deletion in a second patient with Wilms tumor and aniridia but nonna] intelligence also terminates just proximal to DllS302 (Junien and McBride 1989;G. Bruns et al, unpublished observations).…”

Mapping of a gene determining tuberous sclerosis to human chromosome 11q1411q23

“…Y. Nakamura and C. Julier. These latter probes are random DNA probes that have been assigned to the distal half of chromosome llq (Nakamura and Julier, personal communication; Junien and McBride, 1989). The probe for tyrosinase, pMe1 34-1, was provided by Dr. B. Kwon (Kwon et al, 1987).…”

“…These markers were selected for multipoint analyses because previous linkage and physical mapping studies (Junien and McBride, 1989) had determined their order on chromosome llq to be centromere-tyrosinase-MCT128.1-HHH172-telomere.…”