Mapping of a gene determining tuberous sclerosis to human chromosome 11q1411q23

Report of the committee on the genetic constitution of chromosome 9

“…The data of Kandt et al (1989) on 9 families exclude linkage of ABO to tuberous sclerosis for a distance of 20cM. The data of Smith et al (1990) support the existence of a single locus on chromosome 11, while Janssen (1990) found evidence for heterogeneity with a TSC gene on 9 in some families and 11 in others. A collaborative effort in which 111 families from many sources were analysed in several different ways concluded that there is definitely a gene on 9q in the region of ABL and also a gene on 1 lq, but that the existence of yet another TSC locus cannot be excluded (Haines , 1990).…”

Isolation and mapping of 88 new RFLP markers on human chromosome 8

“…Genes responsible for diseases that include multiple endocrine neoplasia type I (MEN I) (Larsson et al 1988;Nakamura et al 1989), tuberous sclerosis (TS) (Smith et al 1990), ataxia telangiectasia (AT) (Gatti et al 1988), and some forms of asthma and rhinitis (Cookson et al 1989) have been localized on human chromosome 11. This chromosome also contains tumor-suppressor genes for bladder carcinoma (Fearon et al 1985;Tsai et al 1990), breast cancer (Theillet et al 1986;Ali et al 1987;Mackay et al 1988) and hepatocellular carcinoma (Wang and Rogler, 1988).…”

Chromosomal Aberrations and Schizophrenia

“…A complex unbalanced translocation involving a partial trisomy of the long arm of chromosome 11, observed in a neonate with cardiac rhabdomyoma (Clark et al, 1988), focused the search for a tuberous sclerosis (TS) gene on the 11q23 region, although positive linkage to the ABO locus on chromosome 9 had already been found in some families (Fryer et al, 1987). Researchers subsequently reported significant linkage of TS to markers from 11q22-11q23 (Smith et al, 1990). …”