Report of the committee on the genetic constitution of chromosomes 10, 11, and 12

Genetic analysis of tumorigenesis: a conserved region in the human and Chinese hamster genomes contains genetically identified tumor-suppressor genes.

“…The seven mapped genes were localized on Chinese hamster chromosome 3 as follows: CAT and INS at 3p0 and 3p0-1 on the short arm and PTH, CALC, and HBBC linked at 3q3-4, HRAS at 3q4, and FES at 3q5 on the long arm. This arrangement is quite different from that of human lip, in which the published order (3,24) A phylogenetic comparison of the localization of these genes is of interest. The recently developed procedures of high-resolution chromosome banding and gene mapping (including in situ hybridization) have allowed extensive comparative gene mapping among mammals (25).…”

“…In this paper we describe the mapping of Chinese hamster chromosome 3 by in situ hybridization with probes of genes known to reside on human lip, a chromosome arm that carries both an oncogene (HRAS) and one or two tumorsuppressor genes (2,3).…”

CD56+, NKp46+ cell line (MZ93) expressing T-cell and myeloid antigens

“…The CD56 gene is located on chromosome 11q23 [11], which is also known as a break-point region of acute leukemia and lymphoma to produce fusion products of the mixed leukemia lymphoma (MLL) gene as a result of balanced translocation [12]. The expression of CD56 is sometimes observed in hematopoietic malignancies, including NK-cell tumors [13 -16], AML [17 -19], and multiple myeloma [20].…”

A third human CALC (pseudo)gene on chromosome 11

“…H6ppener, Institute of Molecular Biology, State University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands [3,4]. In medullary thyroid carcinoma (MTC; a tumour of the CT-producing thyroidal C-cells), both CT mRNA and CGRP mRNA are produced from the human CT/CGRP gene (or 'CALC-I gene', [5]). In addition, a structurally related gene has been identified in the human genome, encoding a second CGRP (CGRP-II) differing from the previously known human CGRP (CGRP-I) in 3 of the 37 amino acids.…”

“…In addition, a structurally related gene has been identified in the human genome, encoding a second CGRP (CGRP-II) differing from the previously known human CGRP (CGRP-I) in 3 of the 37 amino acids. This second human CT/CGRP gene (or 'CALC-II gene', [5]) is probably a pseudogene for a second human CT [6,7]. CGRP-II mRNA has been detected in MTC [81 and in Ewing sarcoma cell lines [91.…”