Report of ESCO WG on non‐plastic Food Contact Materials

,

doi:10.2903/sp.efsa.2011.en-139

Cited by 7 publications

(7 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some food contact materials have not been covered by specific European legislation yet such as paper and board [1,5] although they are the most commonly used food packaging materials together with plastic materials [1]. The European Food Safety Authority (EFSA) has created a document about the migration from non-plastic food contact materials [23]. Paper and board can be treated as monolayer plastic packaging materials because the diffusion rate decreases with the increase in the molecular weight of the migrants [ 24] although the transfer into the foodstuff could happen much faster in the paper material than the migration from plastics [16].…”

Section: A C C E P T E D Mmentioning

confidence: 99%

The behaviour of Tenax as food simulant in the migration of polymer additives from food contact materials by means of gas chromatography/mass spectrometry and PARAFAC

Rubio

Valverde-Som

Sarabia

et al. 2019

Journal of Chromatography A

View full text Add to dashboard Cite

 Migration of polymer additives from food contact materials into Tenax was studied  PARAFAC enabled the unequivocal identification in the presence of coeluting compounds  Some of the m/z ratios of the coeluting interferents were shared with the analytes  Tenax as a suitable food simulant is questioned considering its adsorption capability  BP and DiBP have migrated from PVC film and from PP coffee capsules

show abstract

Section: A C C E P T E D Mmentioning

confidence: 99%

The behaviour of Tenax as food simulant in the migration of polymer additives from food contact materials by means of gas chromatography/mass spectrometry and PARAFAC

Rubio

Valverde-Som

Sarabia

et al. 2019

Journal of Chromatography A

View full text Add to dashboard Cite

show abstract

“…All study substances were, however, selected based on positive predictions in so-called global (i.e., general) in silico models. Poor performance of such models for azo dyes has been reported in the literature; the azo group is often identified as a mutagenic moiety (Benigni and Bossa, 2008;Ferrari and Gini, 2010) without consideration of the potential For substances without publicly available genotoxicity data and that are commercially available, the previously reported in silico results (Van Bossuyt et al, 2017) were thus highly predictive for the in vitro results, as more than 83% (10/12) were indeed mutagenic in the Ames test. Taking into consideration that the substances have only been tested in 2 out of the 5 standard bacterial tester strains (OECD, 1997), the predictive performance of the in silico approach may be even higher.…”

Section: Fig 2: Ames Test Results For the Substance 1-(methylamino)anthraquinonementioning

confidence: 99%

“…At the Member State level, legislation for non-plastics is usually limited and detailed requirements are rarely set. Hence, it is not surprising that current migration issues mainly arise from non-plastic FCM rather than from their plastic counterparts (EFSA, 2012). Printed paper and board FCM constitute a major group of non-plastics and are recognized as an im-…”

mentioning

confidence: 99%

Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches. The example of food contact materials_suppl

Bossuyt¹

2018

ALTEX

View full text Add to dashboard Cite

Due to the exponentially growing number of substances requiring safety evaluation, efficient prioritization strategies are needed to identify those of highest concern. To limit unnecessary animal testing, such strategies should respect the 3R principles (Replacement, Reduction, Refinement). In the present study, a strategy based on non-animal approaches was developed to prioritize non-evaluated printed paper and board food contact material (FCM) substances for further in-depth safety evaluation. Within the strategy, focus was placed on genotoxicity, a key toxicological endpoint when evaluating safety. By combining in silico predictions with existing in vitro and in vivo genotoxicity data from publicly available literature sources and results from in vitro gene mutation experiments, the 106 study substances could all be assigned to one of the four priority classes (ranging from low to very high concern). Importantly, 19 substances were considered of very high concern due to in vivo genotoxicity. Five of these are furthermore listed as substances of very high concern (SVHC) by the European Chemicals Agency (ECHA), in addition to demonstrating physicochemical properties linked to a high migration potential as well as oral bioavailability and being used in primary food packaging materials. The current animal-free strategy proved useful for the priority ranking of printed paper and board FCM substances, but it may also be considered to prioritize other substances of emerging concern.

show abstract

“…1 As of June 2020, more than 86,000 chemicals were approved for use in the United States, 2 and at least 4,000 of those are Plastic-Derived Chemicals (PDCs) present in food contact materials. 3,4,5 PDCs such as Bisphenol A (BPA), phthalates, and other plastic derivations are present in approximately 97% of the U.S. population. 6,7 Human and animal studies have also identified PDCs compounds as contributors to cancer 10-21 , cardiovascular disorders 12,22-29, obesity 30-36 , type 2 diabetes 35,37-39 , metabolic syndrome 31-33,40,41 , neurological and behavioral disorders 42,43 also including Alzheimer’s Disease 12,40,44-48 , as well as reproductive 13,49-56 , and developmental disorders 13,57-62 and allergies 63-70 .…”

Section: Introductionmentioning

confidence: 99%

Stricter protocols combined with a clinical serum biomarker can increase replicability and causality for dietary intervention studies. Plus empirical data on BPA regrettable substitutions

Perdue¹,

Reus

Breemen

et al. 2022

Preprint

View full text Add to dashboard Cite

Effective regulation of harmful environmental chemicals found in wide variety of consumer products and consumables has been thwarted by the lack of agreement between government scientists and university/academic laboratories regarding the quantification of significant human harms. This is particularly relevant regarding plastic-derived chemicals (PDCs), such as Bisphenol A, now that the federal CLARITY-BPA program has failed to achieve any credible, human-significant scientific consensus. Because of this disagreement, direct, clinical human experimental data is vital to resolving this situation. In an effort to develop direct human-relevant data, some academic investigators have employed dietary intervention studies in an attempt to shed light on the controversy. Unfortunately, dietary intervention efforts thus far have not demonstrated causality or replicability. Investigators of this study propose a novel human dietary intervention protocol that can be both replicable and causal. This first-of-a-kind dietary intervention study explores a potential causal relationship between human serum levels of BPA and High-Sensitivity C-Reactive Protein (hsCRP), a proven clinical indicator of inflammation. Investigators used the equivalent of a USDA-defined typical diet followed by a PDC-reduced diet to compare blood levels of hsCRP. This proof-of-concept investigation is the first to use an easily accessible, medically-accepted clinical laboratory test to directly measure human health effects of PDC reduction. Unexpected phenomena discovered during the investigation offer study protocol modifications to enhance widespread replicability, and economically practical expansion to a substantial proportion of the approximately 84,000 mostly unregulated chemicals found in the human environment. In addition, our LC/MS-MS results offer the first direct quantitative human clinical evidence (of which we are aware) confirming the existence of regrettable substitutions in which product manufacturers have reduced BPA usage while substituting Bisphenol analogues that appear to equal or exceed BPA human toxicity. Bolstered by the unexpected results in this proof-of-concept investigation, novel lessons and techniques described herein may further specific and improved methods and best practices that can enable future dietary interventions to produce replicable, causal human results.

show abstract

Report of ESCO WG on non‐plastic Food Contact Materials

Cited by 7 publications

References 121 publications

The behaviour of Tenax as food simulant in the migration of polymer additives from food contact materials by means of gas chromatography/mass spectrometry and PARAFAC

The behaviour of Tenax as food simulant in the migration of polymer additives from food contact materials by means of gas chromatography/mass spectrometry and PARAFAC

Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches. The example of food contact materials_suppl

Stricter protocols combined with a clinical serum biomarker can increase replicability and causality for dietary intervention studies. Plus empirical data on BPA regrettable substitutions

Contact Info

Product

Resources

About