Reply to comments on the article about structural changes in the rat placenta during the last third of gestation discovered by stereology

Optimal placental function is critical for fetal development, and therefore a crucial consideration for understanding the developmental origins of health and disease (DOHaD). The structure of the fetal side of the placental vasculature is an important determinant of fetal growth and cardiovascular development. There are several imaging modalities for assessing feto-placental structure including stereology, electron microscopy, confocal microscopy, micro-computed tomography, light-sheet microscopy, ultrasonography and magnetic resonance imaging. In this review, we present current methodologies for imaging feto-placental vasculature morphology ex vivo and in vivo in human and experimental models, their advantages and limitations and how these provide insight into placental function and fetal outcomes. These imaging approaches add important perspective to our understanding of placental biology and have potential to be new tools to elucidate a deeper understanding of DOHaD.

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Reply to comments on the article about structural changes in the rat placenta during the last third of gestation discovered by stereology

Cited by 4 publications

References 3 publications

Effect of aspartame on the placenta of adult albino rat. A histological and immunohistochemical study

Effect of aspartame on the placenta of adult albino rat. A histological and immunohistochemical study

Quantum dots mediated embryotoxicity via placental damage

Advances in imaging feto-placental vasculature: new tools to elucidate the early life origins of health and disease

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