Replacement effect of vitamin E with grape polyphenols on antioxidant status, immune, and organs histopathological responses in broilers from 1- to 35-d age

Iqbal, Zahid; Kamran, Zahid; Sultan, Javed; Ali, A.; Ahmad, Sayeed; Shahzad, Mirza Imran; Ahsan, Umaır; Ashraf, Shahzad; Sohail, Muhammad Umar

doi:10.3382/japr/pfv009

Cited by 35 publications

(48 citation statements)

References 13 publications

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“…Konowalchuk & Speirs (2009) reported that grape seed proanthocyanidins show up to 50 times more antioxidant activity than vitamin E. Immunity is influenced by oxidative stress and improving the antioxidant status of the animal may enhance its immunity. Similar to the current data, Iqbal et al (2015) found that broilers fed the grape polyphenols diets showed higher (P <0.05) antibody titers against ND virus than those fed the control diet. Additionally, Acamovic & Brooker (2005) reported immunostimulating activity of polyphenols and oregano essential oil with respect to the mononuclear phagocyte system, cell, and humoral immunity.…”

Section: Discussionsupporting

confidence: 80%

“…Also, mild changes in the livers and kidneys of birds fed a diet with a high level of GP polyphenols suggested that even higher polyphenols levels were relatively nontoxic to birds (Iqbal et al, 2015). However, Haseeb et al (2011) reported protective effects of GSE against aluminium toxicity in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding histopathological examination, Iqbal et al (2015) reported that no changes were observed in the livers and kidneys of birds fed low and medium levels of GP polyphenols in diets. Also, mild changes in the livers and kidneys of birds fed a diet with a high level of GP polyphenols suggested that even higher polyphenols levels were relatively nontoxic to birds (Iqbal et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Effects of exogenous tannase enzyme on growth performance, antioxidant status, immune response, gut morphology and intestinal microflora of chicks fed grape pomace

et al. 2018

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An experiment was conducted to study the effects of dietary addition of tannase to feed of chicks including grape pomace (GP) on growth performance, antioxidant status, immune response, blood parameters, gut morphology, intestinal microflora, liver function, and histopathological responses. The experimental diets were i) control (corn and soybean diet) (C); ii) C+10%GP; iii) C+10%GP+T1 (500 mg/kg tannase enzyme); and iv) C+10% GP+T2 (1000 mg/kg tannase enzyme). At 10 days old, the bodyweight (BW) and average daily gain (ADG) of the birds fed the diet supplemented with GP was lower compared with the control group. In contrast with the control, supplementation of diets with 10%GP+1000 mg/kg tannase elevated superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and depressed the malondialdehyde (MDA) level in serum. The addition of GP to the chicken diets had a significant impact on the total anti-sheep red blood cells (SRBC) titers and IgG, and IgM antibodies at 21 and 42 days old. The muscularis thickness of the chicken duodenum decreased in the Trial 3 compared with control groups. The inclusion of GP in the chicken diets reduced the concentration of Escherichia coli and increased that of Lactobacillus compared with the control. The results of the present study suggest that the inclusion of up to 10 percent GP in diets did not adversely affect broiler growth performance, and supplementation of tannase improved the antioxidant status and immune responses,and increased the caecal populations of beneficial bacteria in the cecum of broiler chickens.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of exogenous tannase enzyme on growth performance, antioxidant status, immune response, gut morphology and intestinal microflora of chicks fed grape pomace

et al. 2018

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“…Polyphenols and other compounds of antioxidant system can help vitamin E by recycling or decreasing free radical load (Surai ,2002). Iqbal et al (2015) found that replacement of 75 ppm vitamin E with grape polyphenols improved antioxidant status and immune response of broilers without any negative effect on histopathology of organs. Also, antioxidant activity equal to vitamin E in broiler chickens fed diet supplemented with grape pomace concentrate (GPC) was reported by Brenes et al (2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of grape pomace and vitamin E on performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens

Ebrahimzadeh¹,

Navidshad²,

Farhoomand³

et al. 2018

SA J. An. Sci.

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We investigated the effects of grape pomace (GP) and vitamin E on the performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens. Two hundred and fifty male broiler chickens (Ross 308) were allocated to five dietary treatments (50 birds/treatment) in a completely randomized design. The experimental diets were as follows: i) Control corn-soybean meal diet (C); ii) C + Vitamin E (200 mg/kg of α-tocopherol acetate); iii) The diet containing 5%GP; iv) The diet containing 7.5% GP; v) The diet containing 10% GP. No differences were found in performance of the experimental birds. Birds fed 7.5% GP showed a significant increase in superoxide dismutase (SOD), glutathione peroxidise (GSH-Px) activity and reduced malondialdehyde (MDA) concentration. Antibody titer against Newcastle disease virus (NDV) at 42 days (d) of age in the control and 7.5% GP fed groups were lower than others. The primary IgM concentration of birds fed 10% GP was higher than the birds fed the control diet, the vitamin E supplemented diet or the diet containing 5% GP. The secondary titer against sheep red blood cells (SRBC) was increased significantly in the birds fed 10% GP and the secondary IgG concentration of birds fed 10% GP was higher than the birds fed the control diet and the diets containing 5% or 7.5% GP. In duodenum part of small intestine, villus height/crypt depth ratio and muscularis thickness were decreased. The results of the present study suggest that the inclusion of up to 10% GP in diets did not adversely affect broiler chickens' performance and improved the antioxidant and immune responses of broiler chickens. ______________________________________________________________________________________

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“…A number of researches reported that VE is able to fix and increase performance (Ajakaiye et al, 2011;Ciftci et al, 2005), egg production (Bolukbasi et al, 2007;Ciftci et al, 2005;Irandoust et al, 2012), quality of eggs (Ciftci et al, 2005;Jiang et al, 2013), immune system (Asli et al, 2007;Da Silva et al, 2009;Iqbal et al, 2015), and decrease malondialdehyde (Brenes et al, 2008;Goni et al, 2007;Jiang et al, 2013;Voljc et al, 2011) during heat stress.…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Mangosteen Pericarp Meal and Vitamin E on Egg Quality and Blood Profile of Laying Hens

Rusli¹,

Wiryawan

Toharmat

et al. 2015

Med Pet

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This research aimed to study the supplementation effects of mangosteen pericarp meal (MPM) and vitamin E (VE) in the diets on the egg quality and blood profile of laying hens. This research used 160 laying hens of Lohman strains 24 weeks of age. The observation was conducted for 11 weeks. A completely randomized design with four treatments and four replications (10 birds each) was used in this experiment. The treatments consisted of R0 (control diet), R1 (R0 + 1 g MPM/kg ration), R2 (R0 + 2 g MPM/kg ration) and R3 (R0 + 200 mg VE/kg ration). Variables measured were egg quality, yolk cholesterol, and blood profiles. The data were analyzed by using analysis of variance (ANOVA) and any significant difference between the treatment means were further tested by Duncan's Multiple Range Test. The results showed that supplementation of 1 g MPM/kg ration in the diet significantly (P<0.05) decreased blood triglycerides compared with the control, laying hens fed with diet suplemented with of 2 g MPM/kg ration, and laying hens with diet suplemented with 200 mg VE/kg ration. Supplementation of MPM and VE did not affect (P>0.05) egg quality (except shell thickness), blood cholesterol, and HDL, respectively. In conclusion, supplementation of 1 g MPM/kg in the diet of laying hens could decrease blood triglycerides.

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Replacement effect of vitamin E with grape polyphenols on antioxidant status, immune, and organs histopathological responses in broilers from 1- to 35-d age

Cited by 35 publications

References 13 publications

Effects of exogenous tannase enzyme on growth performance, antioxidant status, immune response, gut morphology and intestinal microflora of chicks fed grape pomace

Effects of exogenous tannase enzyme on growth performance, antioxidant status, immune response, gut morphology and intestinal microflora of chicks fed grape pomace

Effects of grape pomace and vitamin E on performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens

Supplementation of Mangosteen Pericarp Meal and Vitamin E on Egg Quality and Blood Profile of Laying Hens

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