Repigmentation of vitiligo‐associated leukotrichia after autologous, non‐cultured melanocyte‐keratinocyte transplantation

Abstract

Melanocyte-keratinocyte transplantation may represent a good therapeutic option for the repigmentation of vitiligo-associated leukotrichia. This series includes only four responsive cases. Larger prospective studies are needed to determine the true response rate and mechanism of repigmentation.

Follicular unit extraction of leukotrichia and replacement with follicular units from scalp in combination with epidermal cell suspension in a case of vitiligo

“…5 Repigmentation of leukotrichia in 88.09% of lesions and 69.23% of patients has been reported in the previous two retrospective studies with NCECS. 6,7 We did not observe any repigmentation of leukotrichia with NCECS. However, 95% repigmentation of the vitiliginous lesion was seen.…”

Efficacy and safety of noncultured melanocyte‐keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence

“…Numerous studies have demonstrated the tolerability and efficacy in repigmentation of affected areas with MKTP in patients with refractory, stable vitiligo . However, the response rates have been largely variable, with 13–86% of patients achieving 95–100% repigmentation .…”

“…In 1992, the use of epidermal suspensions (containing melanocytes and keratinocytes) for repigmentation was introduced . The techniques were modified and presented by Olsson and Juhlin in 1998 and have been further refined by Mulekar and others to current autologous noncultured MKTP techniques as described in this review …”

“…The process of MKTP for vitiligo and other leukodermas has been described in numerous studies . Importantly, the majority of these studies are case series, and there are few clinical trials.…”