Follicular unit extraction of leukotrichia and replacement with follicular units from scalp in combination with epidermal cell suspension in a case of vitiligo

Pangti, Rashi; Gupta, Vishal; Gupta, Somesh

doi:10.1111/dth.13916

Cited by 2 publications

(3 citation statements)

References 8 publications

(7 reference statements)

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“…8 Surgical modalities are thought to lead to improvement by replenishing absent or deficient melanocyte reservoirs in hair follicles. 1,2 In our patient, there was near-complete repigmentation of her eyelashes with topical tofacitinib. This may indicate either the presence of melanocytes in white hair follicles, though in smaller numbers, or the migration of melanocytes from adjacent hair follicle melanocyte reservoirs.…”

Section: Discussionmentioning

confidence: 60%

Repigmentation of vitiligo-associated eyelash leukotrichia with topical tofacitinib

Kim

Craiglow

2021

JAAD Case Reports

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Section: Discussionmentioning

confidence: 60%

Repigmentation of vitiligo-associated eyelash leukotrichia with topical tofacitinib

Kim

Craiglow

2021

JAAD Case Reports

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“…unit extraction and hair transplantation can be attempted in small leukotrichic areas. 23 Leukotrichic hair also repigment with cell-based surgeries of the underlying skin. 24,25 Large areas require cell-based surgical therapies permitting expansion and high recipient coverage compared to donor areas, like noncultured epidermal cell suspension.…”

Section: Investigationsmentioning

confidence: 99%

“…There is no evidence that patients presenting with rapidly progressive premature canities without any other identifiable causes respond to immunosuppressives, although it might be worth exploring. Follicular unit extraction and hair transplantation can be attempted in small leukotrichic areas 23 . Leukotrichic hair also repigment with cell‐based surgeries of the underlying skin 24,25 .…”

Section: Treatmentmentioning

confidence: 99%

Unravelling the paradox of reverse chronology in follicular vitiligo

Mehta

Abdallah

Gupta

2022

Dermatological Reviews

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Follicular vitiligo is a recently proposed variant of vitiligo, characterized by a primary or predominant depigmentation of hair follicles with no to limited involvement of the interfollicular skin in a nonsegmental distribution, in contrast to vitiligo vulgaris where the opposite predominance and sequence of progression is seen. It is difficult to recognize follicular vitiligo when it presents as isolated leukotrichia without interfollicular skin depigmentation, and the diagnosis is often made in hindsight after the interfollicular skin becomes involved. In follicular vitiligo, the immune response is primarily directed towards hair follicle melanocytes, in contrast to vitiligo vulgaris, in which antigenically distinct melanocytes of the interfollicular skin are targeted. Rapid graying of hair, frequent involvement of the terminal hair of the scalp, eyelashes, and beard, proposed autoimmune response against hair follicle melanocytes, and a proposed loss of immune tolerance of hair follicle melanocytes are the features shared by follicular vitiligo and alopecia areata. Targeted agents such as JAK–STAT pathway inhibitors which have been shown to work in both alopecia areata and vitiligo vulgaris can be useful in the progressive stage of follicular vitiligo.

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Follicular unit extraction of leukotrichia and replacement with follicular units from scalp in combination with epidermal cell suspension in a case of vitiligo

Cited by 2 publications

References 8 publications

Repigmentation of vitiligo-associated eyelash leukotrichia with topical tofacitinib

Repigmentation of vitiligo-associated eyelash leukotrichia with topical tofacitinib

Unravelling the paradox of reverse chronology in follicular vitiligo

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