Repigmentation of Hair Following Photosensitive Dermatitis

Bhutani, L. K.; Minocha, YC; Dhir, G G; Rao, D. Srinivasa

doi:10.1159/000250904

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…Localized hypertrichosis may be observed in patients treated with oral photochcmotherapy (Singh & Lai, 1967;Braun-Falco, Hoffman & Plewig, 1976), and favourable results have been obtained in the treatment of alopecia areata treated with PUVA (Sidi & Bourgeois-Spinasse, 1955;Weissman etal.^ 1978). Repigmentation of white hair after light exposure also suggests direct stimulation of hair follicle melanocytcs (Bhutani et al, 1978). Improvement in vitiligo seems to occur clinically in successive waves.…”

Section: Discussionmentioning

confidence: 95%

PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study

et al. 1979

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Repigmentation induced by oral photochemotherapy (8-MOP + UV-A) in four patients with vitiligo has been studied by histochemical and ultrastructural techniques. Hypertrophic melanocytes were demonstrated both in the middle and deep portions of the hair follicles in the centre of islands of repigmentation and also in the epidermis of the expanding repigmenting border. Mitosis of melanocytes was absent in these areas. Ultrastructural study showed that the melanocytes of repigmented areas were hyperactive. The melanosomes were larger than those of surrounding healthy skin, although the mode of packaging was unaltered. These observations suggest that melanocytes repigmenting vitiliginous skin under the influence of oral photochemotherapy are derived from a melanocytic reservoir localized in the hair follicles.

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Section: Discussionmentioning

confidence: 95%

PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study

et al. 1979

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“…[78][79][80] Hair darkening has also been described after X-ray irradiation and following electron beam therapy. [51] Shaffrali et al reported darkening of gray hair in two patients with porphyria cutanea tarda.…”

Section: Management Managementmentioning

confidence: 99%

Premature graying of hair

Pandhi¹,

Khanna²

2013

Indian J Dermatol Venereol Leprol

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Premature graying is an important cause of low self-esteem, often interfering with socio-cultural adjustment. The onset and progression of graying or canities correlate very closely with chronological aging, and occur in varying degrees in all individuals eventually, regardless of gender or race. Premature canities may occur alone as an autosomal dominant condition or in association with various autoimmune or premature aging syndromes. It needs to be differentiated from various genetic hypomelanotic hair disorders. Reduction in melanogenically active melanocytes in the hair bulb of gray anagen hair follicles with resultant pigment loss is central to the pathogenesis of graying. Defective melanosomal transfers to cortical keratinocytes and melanin incontinence due to melanocyte degeneration are also believed to contribute to this. The white color of canities is an optical effect; the reflection of incident light masks the intrinsic pale yellow color of hair keratin. Full range of color from normal to white can be seen both along individual hair and from hair to hair, and admixture of pigmented and white hair is believed to give the appearance of gray. Graying of hair is usually progressive and permanent, but there are occasional reports of spontaneous repigmentation of gray hair. Studies evaluating the association of canities with osteopenia and cardiovascular disease have revealed mixed results. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, there is paucity of effective evidence-based treatment options. Reports of repigmentation of previously white hair following certain inflammatory processes and use of drugs have suggested the possibility of cytokine-induced recruitment of outer sheath melanocytes to the hair bulb and rekindled the hope for finding an effective drug for treatment of premature canities. In the end, camouflage techniques using hair colorants are outlined.

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“…Verbov 9 subsequently described a case of erosive candidiasis of the scalp in a 72‐year‐old woman, with regrowth of black hairs in the previously inflamed areas. Another patient with an exudative red dermatosis on sun‐exposed areas of the skin and scalp was noticed to have darkening of the roots of the hair at all previously inflamed sites, once the condition was treated 10 . Hair darkening has also been described after X‐irradiation of the scalp, 11 psoralen plus ultraviolet A therapy for Sézary syndrome, 12 and following electron beam therapy 13…”

Section: Discussionmentioning

confidence: 99%

Hair darkening in porphyria cutanea tarda

2002

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Repigmentation of grey hair is rare, but has been described in several clinical settings. It has most often been reported as a postinflammatory effect, but several drugs, chronic arsenic exposure and coeliac disease have also been cited in addition to darkening as a spontaneous phenomenon. We report two patients with sustained repigmentation of the hair in association with porphyria cutanea tarda. The mechanism for this repigmentation remains elusive, but presumably involves recruitment of outer root sheath melanocytes, which are then activated to form functional hair bulb melanocytes.

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Repigmentation of Hair Following Photosensitive Dermatitis

Abstract: A case of repigmentation of the scalp hair following photosensitive dermatitis is reported. The possible clinical application of this observation has been discussed.

Cited by 9 publications

References 4 publications

PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study

PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study

Premature graying of hair

Hair darkening in porphyria cutanea tarda

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