PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study

Ortonne, Jean‐Paul; Macdonald, D.M.; Micoud, A; Thivolet, J

doi:10.1111/j.1365-2133.1979.tb15285.x

Cited by 112 publications

(65 citation statements)

References 18 publications

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“…The main reservoir of melanocytes is the hair follicle, in particular the external root sheath. 2,3 This is supported by the clinical observation that the face and neck have the maximum response rate to medical therapies, followed by proximal extremities and trunk. Acral parts of extremities and nonhairy areas such as the wrist, feet and male genitals respond poorly.…”

Section: What Does This Study Add?mentioning

confidence: 63%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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SummaryBackground Vitiligo is a disfiguring disease, characterized frequently by the presence of de-pigmented macules and/or patches. Traditional therapies are essentially medical and are most preferred by dermatologists. Surgical therapies, however, are amongst the most effective interventions for vitiligo but are limited by their invasive nature, as well as the training and expertise needed to perform specific procedures. Objectives To assess the evidence for the effectiveness, safety and applicability of the various surgical methods in the treatment of vitiligo. Methods For this systematic review of vitiligo surgical therapies, our searches included: PubMed, MEDLINE and Cochrane databases. Results We reviewed research studies reporting on split thickness skin grafts (STSG), punch/mini-graft, blister roof grafting, cultured and non-cultured cellular transplantation (MKTP). While all methods vary in their repigmentation outcomes, STSG is found to have the highest repigmentation success rate. Overall, post-operative complications included milia, scarring, cobblestone appearance or hyperpigmentation of treated areas. Conclusion This review highlights the need for more randomized controlled trials in this field, underpinned by a more standardized objective approach to the assessment of repigmentation following surgical interventions.

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Section: What Does This Study Add?mentioning

confidence: 63%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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“…Studies demonstrated that loss of McSCs leads to hair graying (42). Also, bulge McSCs are implicated in repopulating epidermal melanocytes during the recovery process of vitiligo, a disease characterized by skin depigmentation due to a loss of mature skin melanocytes (53). How McSC behavior is coordinately regulated with HFSCs throughout the hair cycle has recently been examined.…”

Section: Stem Cell Interactions Within the Niche -Another Playermentioning

confidence: 99%

Dissecting the bulge in hair regeneration

Myung¹,

Ito²

2012

J. Clin. Invest.

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The adult hair follicle houses stem cells that govern the cyclical growth and differentiation of multiple cell types that collectively produce a pigmented hair. Recent studies have revealed that hair follicle stem cells are heterogeneous and dynamic throughout the hair cycle. Moreover, interactions between heterologous stem cells, including both epithelial and melanocyte stem cells, within the hair follicle are just now being explored. This review will describe how recent findings have expanded our understanding of the development, organization, and regeneration of hair follicle stem cells. At a basic level, this review is intended to help construct a reference point to integrate the surge of studies on the molecular mechanisms that regulate these cells.

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“…usually after 1 week) phototherapy was used to induce proliferation and migration of melanocytes in the recipient sites. (29)(30)(31) The repigmentation rate in these studies according to the review by Njoo et al was 87%, whereas Ozdemi et al reported rates between 25% -65%. (29)(30)(31)(32)(33)(34)(35)(36) In the study by Maleki et al, ten patients with refractory vitiligo who were treated by suction blister graft and subsequent PUVA therapy reported over 90% repigmentation in seven patients.…”

Section: Discussionmentioning

confidence: 89%

Suction Blister Grafting- Still a Useful Modality for Treatment of Resistant and Stable Vitiligo

S¹,

Chittoory²

2017

jemds

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BACKGROUNDVitiligo is a common depigmentation disorder due to absence of functional melanocytes in the affected area. Depending on the type, extent and duration of vitiligo, conventional medical therapies and phototherapy are used. Medical treatment is effective in only 60% -70% of the patients. This has led to the evolution of various surgical modalities to treat recalcitrant stable lesions. The aim of this study was to determine the efficacy of suction blister grafts for treatment of recalcitrant and stable vitiligo. MATERIALS AND METHODSThis study was conducted on 20 patients with stable vitiligo. They included lip vitiligo (6 cases), segmental vitiligo (6 cases) and focal vitiligo (8) that were resistant to conventional medical treatments. Manual suction with 20 cc disposable syringes for blisters at donor site and dermabrasion at recipient site was done. The blister was separated, fixed at recipient site and dressing was done followed by NBUVB thrice a week for 3 months. Repigmentation of lesions was evaluated monthly for 6 months after treatment. Repigmentation rates > 90%, 71% -90%, 51% -70% and < 50% were graded as complete, good, moderate and poor respectively. RESULTSThis study includes 20 patients (10 female and 10 male) with stable vitiligo were evaluated for response following suction blister grafting with thrice weekly post-graft phototherapy. Reponses to treatment after a 6-month followup were 'complete,' 'good' and 'moderate' in 12 (60%), 6 (30%) and 2 (10%) patients respectively and one patient was lost for followup. CONCLUSIONThe grafting procedures in vitiligo are performed for cosmetic purposes. Proper selection of the patient is the most important factor for achieving a good cosmetic result. Stability of the disease process is the most important parameter to achieve a successful outcome. Suction blister grafting gives excellent cosmetic results with minimal chances of scarring at the donor or recipient sites.

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PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study

Cited by 112 publications

References 18 publications

Surgical interventions for vitiligo: an evidence-based review

Surgical interventions for vitiligo: an evidence-based review

Dissecting the bulge in hair regeneration

Suction Blister Grafting- Still a Useful Modality for Treatment of Resistant and Stable Vitiligo

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