Repetitive hypoxia increases lipid loading in human macrophages—a potentially atherogenic effect

Lattimore, Jo-Dee; Wilcox, Ian; Nakhla, Shirley; Langenfeld, Matthias; Jessup, Wendy; Celermajer, David S.

doi:10.1016/j.atherosclerosis.2004.11.010

Cited by 64 publications

(47 citation statements)

References 29 publications

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“…These results suggest that COPD-related hypoxemia and/or hypercapnia are relevant factors for atherosclerosis. Hypoxemia could lead to atherosclerosis through increasing systemic inflammation, oxidative stress, upregulating cell adhesion molecules, inducing hemodynamic stress, and increased foam cell production (15,47,48). The same results were recorded by Ozbay et al (36); they found that oxygen saturation was decreased in COPD patients with a thickened CIMT and reported that both intermittent and continuous hypoxemia resulted in remarkable alterations in CIMT.…”

Section: Discussionsupporting

confidence: 59%

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Hafez¹,

Sobh²,

Abo-Elkheir³

et al. 2017

Eurasian J Pulmonol

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Section: Discussionsupporting

confidence: 59%

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Hafez¹,

Sobh²,

Abo-Elkheir³

et al. 2017

Eurasian J Pulmonol

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“…Ten związek przyczynowo-skutkowy został potwierdzony przez wyniki ostatnich badań eksperymentalnych na zwierzętach i w populacji człowieka [33]. Występujące u części chorych na POChP niedotlenienie prowadzi do aktywacji procesu zapalnego, zwiększa stres oksydacyjny oraz możliwości adhezyjne komórek, co w konsekwencji sprzyja aterogenezie [34,35]. Etiologia przewlekłego procesu zapalnego w POChP jest nieznana.…”

Section: Patogeneza Współistnienia Pochp I Chorób Sercowo-naczyniowychunclassified

Przewlekła Obturacyjna Choroba Płuc i Choroby Sercowo-Naczyniowe—“Kontinuum Sercowo-PłUcne”

Batura‐Gabryel¹,

Grabicki²

2014

Advances in Respiratory Medicine

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Przewlekła obturacyjna choroba płuc i choroby sercowo--naczyniowe -"kontinuum sercowo-płucne"Chronic obstructive pulmonary disease and cardiovascular diseases -'cardiopulmonary continuum' Praca nie była finansowana AbstractChronic obstructive pulmonary disease (COPD) is characterised by persistent airflow limitation and extrapulmonary comorbidities, which contribute to the overall severity. Some risk factors, with tobacco smoking as the most serious one, lead to a chronic, systemic inflammation that plays the main role in the pathogenesis of COPD and comorbidities, including cardiovascular diseases (CVD). The course of COPD is diverse; it depends on pathologies in the respiratory system and on other organ dysfunctions. CVDs are the most commonly recognised comorbidities in COPD patients. The severity and natural course of COPD, as well as quality of the patient's life, are influenced by them. CVDs are frequently the reason for hospitalisation and may lead to death. They are also an important prognostic factor. Comorbidities may prolong exacerbation of COPD. On the other hand, COPD is an independent risk factor of CVD. The prevalence of COPD is high in patients suffering from coronary artery disease, and airflow limitation is a major risk factor for chronic heart failure. These complex interactions between heart and lung can be denoted as 'cardiopulmonary continuum'. These dependencies are not recognised in detail. Currently research is being done, which attempts to explain these complicated relations. For many years COPD and CVD were not connected. Today it is known that patients suffering from COPD must be provided comprehensive care. It is necessary to monitor the risk of CVD and their influence on the COPD course. Careful and proper treatment of all diseases is essential. An interdisciplinary team with good cooperation should prepare a plan of COPD treatment with simultaneous therapy of comorbidities. Key words: COPD, cardiovascular diseases, comorbiditiesPneumonol. Alergol. Pol. 2014; 82: 590-596 StreszczeniePrzebieg przewlekłej obturacyjnej choroby płuc (POChP) charakteryzuje się nie tylko utrzymującymi się ograniczeniami przepływu powietrza przez oskrzela, ale również współwystępowaniem patologii pozapłucnych. Czynniki ryzyka, w tym przede wszystkim palenie tytoniu, prowadzą do rozwoju przewlekłego, ogólnoustrojowego procesu zapalnego, który pełni główną rolę w patogenezie zarówno POChP, jak i wielu chorób towarzyszących, w tym sercowo-naczyniowych. Obraz kliniczny POChP jest różnorodny i zależy od nasilenia zmian w układzie oddechowym, jak również od dysfunkcji innych narządów i chorób współistniejących. U osób z chorobą obturacyjną płuc najczęściej obserwuje się współwystępowanie chorób układu sercowo-naczyniowego, które wpływają na jej ciężkość i przebieg naturalny, na jakość życia chorych oraz wielokrotnie są przyczyną hospitalizacji i zgonu. Są również ważnym czynnikiem prognostycznym. Obecność dodatkowych chorób może przedłużać zaostrzenie POChP. Z drugiej strony POChP jest niezależnym czynnikiem ryz...

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“…Hypoxia has been shown to have a number of effects that influence atherogenesis. These include increasing systemic inflammation and oxidative stress, up-regulating cell adhesion molecules, and inducing hemodynamic stress (58)(59)(60). Increased foam cell production, a critical constituent of unstable atherosclerotic plaques, is also stimulated when macrophages are exposed to hypoxic conditions (58).…”

Section: Hypoxia and Cardiovascular Diseasementioning

confidence: 99%

Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease

MacNee¹,

Maclay²,

McAllister³

2008

Proceedings of the American Thoracic Society

110

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Cardiovascular disease represents a considerable burden in terms of both morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). For 20 years, forced expiratory volume in 1 second (FEV 1 ) has been an established predictor of cardiovascular mortality among smokers, never-smokers, and patients with COPD. We review evidence for increased cardiovascular risk in COPD. In addition, we assess the emerging evidence which suggests that hypoxia, systemic inflammation, and oxidative stress in patients with COPD may cause cardiovascular disease. We also discuss alternative hypotheses that the endothelium and connective tissues in the arteries and lungs of patients with COPD and cardiovascular disease have a shared susceptibility to these factors.

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Repetitive hypoxia increases lipid loading in human macrophages—a potentially atherogenic effect

Cited by 64 publications

References 29 publications

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Przewlekła Obturacyjna Choroba Płuc i Choroby Sercowo-Naczyniowe—“Kontinuum Sercowo-PłUcne”

Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease

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