Repeated Prolonged Exercise Decreases Maximal Fat Oxidation in Older Men

Morville, Thomas; Rosenkilde, Mads; Munch‐Andersen, Thor; Andersen, Peter Riis; Groenbæk, Katja Kjær; Helbo, Signe; Kristensen, M; Vigelsø, Andreas; Mattsson, Nick; Rasmusen, Hanne Kruuse; Guadalupe‐Grau, Amelia; Fago, Angela; Hansen, Christina; Twelkmeyer, Brigitte; Andersen, Jesper L.; Dela, Flemming; Helge, Jørn Wulff

doi:10.1249/mss.0000000000001107

Cited by 8 publications

(28 citation statements)

References 39 publications

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“…Plasma hsCRP, TNFα, and IL-18 were not changed after the 14 days (Table 2), but there was a significantly higher plasma IL-6 concentration (Table 2). The plasma leptin and adiponectin concentrations at rest remained unchanged (Table 2; previously published Rosenkilde et al, 2015; Morville et al, 2017). …”

Section: Resultsmentioning

confidence: 57%

“…Plasma glucose concentrations at rest remained unchanged and there was a trend ( P = 0.06) toward higher plasma insulin after cycling (Table 2; Morville et al, 2017). The glycosylated hemoglobin was not significantly increased, probably due to the limited time of the experiment, but there was a trend ( P < 0.07) toward an increase in the quantitative insulin sensitivity check index (QUICKI) (Table 2).…”

Section: Resultsmentioning

confidence: 94%

“…In summary all six subjects completed the full distance of 2,706 km (1,681 miles) in 14 days with an average daily distance of 193 ± 10 km·day −1 (range: 167–235 km·day −1 ). Daily exercise time was 10 h and 31 ± 37 min·day −1 with an exercise intensity of 53.1 ± 1.1% of VO 2peak and approximately 198 ± 58 min·day −1 exercise intensity above 60% of VO 2peak (Morville et al, 2017). After cycling, maximal oxygen uptake was reduced (3.71 ± 0.17 to 3.49 ± 0.20 L O 2 /min and 48 ± 2 to 45 ± 2 mL O 2 /min/kg, P < 0.04) (Morville et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Daily exercise time was 10 h and 31 ± 37 min·day −1 with an exercise intensity of 53.1 ± 1.1% of VO 2peak and approximately 198 ± 58 min·day −1 exercise intensity above 60% of VO 2peak (Morville et al, 2017). After cycling, maximal oxygen uptake was reduced (3.71 ± 0.17 to 3.49 ± 0.20 L O 2 /min and 48 ± 2 to 45 ± 2 mL O 2 /min/kg, P < 0.04) (Morville et al, 2017). The peak workload attained during the VO 2peak test was not significantly lowered ( P = 0.22) from before to after the 14 days 357 ± 31 and 333 ± 24 watt, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The design of this study has been published in detail elsewhere (Rosenkilde et al, 2015; Morville et al, 2017). In brief, six male recreationally trained cyclists (61 ± 4 years, VO 2peak 48 ± 2 mL·kg −1 ·min −1 ) participated in the study.…”

Section: Methodsmentioning

confidence: 99%

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Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

et al. 2017

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Introduction/Purpose: A number of studies have investigated the effect of training with a moderate exercise dose (3–6 h/weekly) on the inflammatory profile in blood, and the data are inconsistent. Cross-sectional studies indicate a positive effect of physical activity level on inflammation levels and risk of metabolic disease. However, it is not clear whether this may be dose dependent and if very prolonged repeated exercise therefore may be beneficial for low-grade inflammation. Based on this we studied how excessive repeated prolonged exercise influenced low-grade inflammation and adipose tissue anti-inflammatory macrophage content in six older male recreationally trained cyclists. Low-grade inflammation and adipose tissue macrophage content were investigated in six older trained men (age: 61 ± 4 years; VO2peak: 48 ± 2 mL kg−1 min−1) following repeated prolonged exercise.Methods: Cycling was performed daily for 14 days covering in total 2,706 km (1,681 miles). Maximal oxygen uptake (VO2peak) was measured before and after the cycling. Duration and intensity of the exercise were determined from heart rates sampled during cycling. An adipose tissue biopsy from subcutaneous abdominal fat and a blood sample were obtained at rest in the overnight fasted state before and after the cycling. Anti-inflammatory adipose tissue macrophages (ATM) were immunohistochemically stained in cross sectional sections using a CD163 binding antibody. The ATM and adipocyte sizes were analyzed blindly.Results: The cyclists exercised daily for 10 h and 31 ± 37 min and average intensity was 53 ± 1% of VO2peak. Body weight remained unchanged and VO2peak decreased by 6 ± 2% (P = 0.04). Plasma inflammatory cytokines, TNFα and IL-18 remained unchanged, as did hsCRP, but plasma IL-6 increased significantly. CD163 macrophage content remained unchanged, as did adipocyte cell size. The HbA1c was not significantly decreased, but there was a trend (P < 0.07) toward an increased insulin resistance as estimated by the Quicki Index.Conclusion: The regular prolonged exercise did not influence abdominal adipose tissue inflammation, but the higher plasma IL-6 concentration concurrent with a trend toward higher insulin resistance and decreased VO2peak implies that the excessive amount of exercise probably attenuated the possible potential anti-inflammatory effects of exercise.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

et al. 2017

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2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

Morville

Rosenkilde

Mattsson

et al. 2018

The Physician and Sportsmedicine

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The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.

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Extreme duration exercise affects old and younger men differently

et al. 2022

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Aim & Methods: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days. Results: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. VȮ 2 max did not change in younger cyclists, but decreased (p = 0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased See related editorial: Henriksson J. 2022. Extreme duration endurance exercise affects old and younger men differently-Older individuals experience a negative adaptive response affecting cardiovascular function. Acta Physiol (Oxf). e13843.

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Repeated Prolonged Exercise Decreases Maximal Fat Oxidation in Older Men

Cited by 8 publications

References 39 publications

Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

Extreme duration exercise affects old and younger men differently

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