Reorganization of the uncrossed visual pathways as revealed by Fos-like immunoreactivity in rats with neonatal monocular enucleation

Yagi, Fumio; Sakai, Makoto; Ikeda, Yukinobu; Okutani, Fumino; Takahashi, Seiichi; Fukata, Jyunichi

doi:10.1016/s0304-3940(01)01762-1

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Drastic structural rearrangements and changes in synaptic efficiency are induced along the subcortical, thalamocortical and cortico-cortical pathways, especially contralateral to the removed eye (for review see Toldi et al, 1996 ). In subcortical (Lund et al, 1973 ; Yagi et al, 2001 ; Chan et al, 2011 ; Furman and Crair, 2012 ) and cortical (Toldi et al, 1994b , 1996 ; Hada et al, 1999 ; Yagi et al, 2001 ) structures of the rodent visual system, the ME-induced rerouting of retinogeniculate, retinotectal and geniculocortical afferents and callosal inputs corresponds with the recruitment of deafferented neurons and the functional modifications in favor of the remaining eye. This enucleation-dependent reorganization of the uncrossed, ipsilateral visual pathway during development mirrors the perceptual learning ability of enucleated rats exposed to a black-white and horizontal-vertical discrimination task.…”

Section: Monocular Enucleation As a Brain Plasticity Modelmentioning

confidence: 99%

Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss

Nys

Scheyltjens

Arckens

2015

Front. Syst. Neurosci.

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The groundbreaking work of Hubel and Wiesel in the 1960’s on ocular dominance plasticity instigated many studies of the visual system of mammals, enriching our understanding of how the development of its structure and function depends on high quality visual input through both eyes. These studies have mainly employed lid suturing, dark rearing and eye patching applied to different species to reduce or impair visual input, and have created extensive knowledge on binocular vision. However, not all aspects and types of plasticity in the visual cortex have been covered in full detail. In that regard, a more drastic deprivation method like enucleation, leading to complete vision loss appears useful as it has more widespread effects on the afferent visual pathway and even on non-visual brain regions. One-eyed vision due to monocular enucleation (ME) profoundly affects the contralateral retinorecipient subcortical and cortical structures thereby creating a powerful means to investigate cortical plasticity phenomena in which binocular competition has no vote.In this review, we will present current knowledge about the specific application of ME as an experimental tool to study visual and cross-modal brain plasticity and compare early postnatal stages up into adulthood. The structural and physiological consequences of this type of extensive sensory loss as documented and studied in several animal species and human patients will be discussed. We will summarize how ME studies have been instrumental to our current understanding of the differentiation of sensory systems and how the structure and function of cortical circuits in mammals are shaped in response to such an extensive alteration in experience. In conclusion, we will highlight future perspectives and the clinical relevance of adding ME to the list of more longstanding deprivation models in visual system research.

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Section: Monocular Enucleation As a Brain Plasticity Modelmentioning

confidence: 99%

Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss

Nys

Scheyltjens

Arckens

2015

Front. Syst. Neurosci.

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“…Neonatal monocular enucleation (ME) has been often utilized to study developmental mechanisms underlying visual perception and neuroplasticity of the brain because of the extensive changes and reorganization in various regions of the visual system following the complete loss of one eye (Toldi et al, 1996). Previous studies suggested that ME during early postnatal period initiates not only neurodegeneration in both dorsal lateral geniculate nucleus (DLGN) and superior colliculus (SC) in the enucleated side, but also a series of adaptive reactions in the visual and other sensory systems at a later stage (Karlen et al, 2006; Toldi et al, 1994; Yagi et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Physiological changes including enlarged ipsilateral visual field and receptive field in the visual system were observed at 3 months after ME (Fukuda et al, 1983;Jeffery and Thompson, 1986). Plasticity resulted from recruitment of resources to the remaining left eye for adaptation and cross-modal effects were also observed at 3 months to 1 year after ME (Karlen et al, 2006;Toldi et al, 1994;Yagi et al, 2001). However, underlying biochemical or metabolic mechanisms that accompany the morphological, physiological and behavioral changes after ME are not fully understood (Steeves et al, 2008;Toldi et al, 1988Toldi et al, , 1994Yaka et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Metabolic changes in visual cortex of neonatal monocular enucleated rat: a proton magnetic resonance spectroscopy study

Chow

Zhou

Fan

et al. 2010

Intl J of Devlp Neuroscience

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Neonatal monocular enucleation (ME) is often employed to study the developmental mechanisms underlying visual perception and the cross-modal changes in the central nervous system caused by early loss of the visual input. However, underlying biochemical or metabolic mechanisms that accompany the morphological, physiological and behavioral changes after ME are not fully understood. Male Sprague-Dawley rats (N=14) were prepared and divided into 2 groups. The enucleated group (N=8) underwent right ME (right eye removal) at postnatal day 10, while the normal group (N=6) was intact and served as a control. Three weeks after ME, single voxel proton magnetic resonance spectroscopy ((1)H MRS) was performed over the visual cortex of each hemisphere in all animals with a point-resolved spectroscopy (PRESS) sequence at 7 T. The taurine (Tau) and N-acetylaspartate (NAA) levels were found to be significantly lower in the left visual cortex (contralateral to enucleated eye) for enucleated animals. Such metabolic changes measured in vivo likely reflected the cortical degeneration associated with the reduction of neurons, axon terminals and overall neuronal activity. This study also demonstrated that (1)H MRS approach has the potential to characterize neonatal ME and other developmental neuroplasticity models noninvasively for the biochemical and metabolic processes involved.

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Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view

Mezzera

López‐Bendito

2016

Journal of Chemical Neuroanatomy

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Reorganization of the uncrossed visual pathways as revealed by Fos-like immunoreactivity in rats with neonatal monocular enucleation

Cited by 5 publications

References 19 publications

Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss

Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss

Metabolic changes in visual cortex of neonatal monocular enucleated rat: a proton magnetic resonance spectroscopy study

Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view

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