Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view

Mezzera, Cecilia; López‐Bendito, Guillermina

doi:10.1016/j.jchemneu.2015.09.005

Cited by 20 publications

(18 citation statements)

References 100 publications

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“…Early sensory experience shapes the development of the matched thalamocortical and intracortical connections underlying a subsequently deprived sense (for review, e.g., Hensch, 2005; Sur and Rubenstein, 2005; Espinosa and Stryker, 2012; Mezzera and Lopez-Bendito, 2016). However, it is largely unknown if and how sensory experience shapes the matched and non-matched thalamocortical and corticocortical connections underlying the other (spared) senses and how experience shapes the non-matched connections of the deprived sense.…”

Section: Resultsmentioning

confidence: 99%

Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices

et al. 2017

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The nervous system integrates information from multiple senses. This multisensory integration already occurs in primary sensory cortices via direct thalamocortical and corticocortical connections across modalities. In humans, sensory loss from birth results in functional recruitment of the deprived cortical territory by the spared senses but the underlying circuit changes are not well known. Using tracer injections into primary auditory, somatosensory, and visual cortex within the first postnatal month of life in a rodent model (Mongolian gerbil) we show that multisensory thalamocortical connections emerge before corticocortical connections but mostly disappear during development. Early auditory, somatosensory, or visual deprivation increases multisensory connections via axonal reorganization processes mediated by non-lemniscal thalamic nuclei and the primary areas themselves. Functional single-photon emission computed tomography of regional cerebral blood flow reveals altered stimulus-induced activity and higher functional connectivity specifically between primary areas in deprived animals. Together, we show that intracortical multisensory connections are formed as a consequence of sensory-driven multisensory thalamocortical activity and that spared senses functionally recruit deprived cortical areas by an altered development of sensory thalamocortical and corticocortical connections. The functional-anatomical changes after early sensory deprivation have translational implications for the therapy of developmental hearing loss, blindness, and sensory paralysis and might also underlie developmental synesthesia.

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Section: Resultsmentioning

confidence: 99%

Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices

et al. 2017

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“…The copyright holder for this this version posted February 14, 2021. ; https://doi.org/10.1101/2021.02.14.431161 doi: bioRxiv preprint Sato et al 9 To further examine whether TCAs are eliminated or neural connections are altered in TCA-ablated mice, the lipophilic dyes DiA and DiI were injected into two different TCA target areas, S1 and the primary visual cortex (V1), respectively, to label TCAs and thalamic neurons retrogradely (Figure 2 from 2 mice) suggests that TCA rewiring from the dLGN or MG to S1 did not occur in TCA-ablated mice, unlike previously reported findings (Mezzera and López-Bendito, 2016). Thus, S1 in TCA-ablated mice receives very few axonal inputs from the VB.…”

Section: Neonatal Ablation Of Tcas Projecting To S1mentioning

confidence: 92%

Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of secretory proteins

Sato¹,

Hatakeyama²,

Iwasato

et al. 2021

Preprint

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Neuronal abundance and thickness of each cortical layer is specific to each area, but how this fundamental feature arises during development remains poorly understood. While some of area-specific features are controlled by intrinsic cues such as morphogens and transcription factors, the exact influence and mechanisms of action by extrinsic cues, in particular the thalamic axons, have not been fully established. Here we identify a thalamus-derived factor, VGF, which is indispensable for thalamocortical axons to maintain the proper amount of layer 4 neurons in the mouse sensory cortices. This process is prerequisite for further maturation of the primary somatosensory area, such as barrel field formation instructed by a neuronal activity-dependent mechanism. Our results also provide an insight into regionalization of brain in that highly site-specific axon projection anterogradely confers further regional complexity upon the target field through locally secreting signaling molecules from axon terminals.

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“…For example, binding of key sensory features in any of the primary sensory areas involved in cross-modal activation may build bottom up cross-sensory objects that facilitate processing of sensory scenes 13 . Alternatively, interactions between cortical and thalamic sensory processing areas may play a critical role in driving cross-modal plasticity 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

et al. 2019

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We experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.

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Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view

Cited by 20 publications

References 100 publications

Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices

Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices

Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of secretory proteins

Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

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