Reorganization of the rat cerebellar cortex during postnatal development following cisplatin treatment

Avella, Debora; Pisu, Maria Bonaria; Roda, Elisa; Gravati, M.; Bernocchi, Graziella

doi:10.1016/j.expneurol.2006.03.034

Cited by 25 publications

(39 citation statements)

References 82 publications

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“…in the lobules that showed several changes in the EGL and Purkinje cell layer after cisPt treatment (Avella et al, 2006;Pisu et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…In this study, we were able to exploit our earlier work on the neurotoxicity of Pt compounds (Avella et al, 2006;Pisu et al, 2005), to study the possible involvement of PrPc in cell proliferation/death, and cell differentiation. Developmental alterations are induced by platinum compounds in lobules VI-VIII of cerebellum during the histogenetic process between PD11 and at PD17, i.e.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Bottone

Veronica

Piccolini

et al. 2012

Journal of Chemical Neuroanatomy

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“…in the lobules that showed several changes in the EGL and Purkinje cell layer after cisPt treatment (Avella et al, 2006;Pisu et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Bottone

Veronica

Piccolini

et al. 2012

Journal of Chemical Neuroanatomy

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“…The changes in the growth and remodeling of Purkinje cell dendrites are an evident proof of brain plasticity as shown during postnatal histogenesis after X-ray irradiation or treatment with cytotoxic substances (Ferguson, 1996;Avella et al, 2006;Li et al, 2006) or in mutant mice (for a review see Katsuyama and Terashima, 2009). …”

Section: Defects Of Cerebellum Fissuresmentioning

confidence: 99%

Postnatal Development of the Central Nervous System: Anomalies in the Formation of Cerebellum Fissures

Cerri¹,

Piccolini²,

Bernocchi³

2010

The Anatomical Record

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A natural defect in rat cerebellum postnatal development has been found in the fissura prima, consisting in various complex configurations of the cerebellar layers. We investigated the genesis of fissure malformations through immunoreactions for PCNA, GFAP, GABAA a6, and calbindin to label proliferating cells of the external granular layer (egl), radial glial fibers, mature granule cells, and Purkinje cells, respectively. Results on critical stages of rat postnatal development provided interesting evidences on how the malformation develops in fissures prima and secunda. Early (postnatal day 10) at the site of malformation, the Bergmann radial glia was often retracted and showed distortions and irregular running. The interruption of GFAP-positive radial glial fibers could fit in with the presence of clusters of PCNA-unlabeled cells in the sites of fusion of the egl; the clusters of cells are granule cells since their soma is labeled by GABAA a6. Moreover, an altered migration of granule cell precursors to the internal granular layer was evident which, in turn, affected Purkinje cell differentiation and the growth of their dendrites. In summary, the changed relationship among glial fiber morphology, granule cell migration, and Purkinje cell differentiation suggests how the Bergmann glial fibers have a basic role in the foliation process, being the driving physical force in directing migration of the granule cells at the base of fissure. Anat Rec, 293:492-501, 2010. V V C 2010 Wiley-Liss, Inc.

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“…GAP-43, CAM-L1 and laminin (Laifenfeld et al, 2002), we found changes in the immunoreactivity for adhesion molecules (Avella et al, 2006) and in the cerebellar cortex after cytotoxic drug treatment. PSA (polisylialated)-NCAM expression greatly increased 7 days after cisplatin administration (Avella et al, 2006). The presence of embryonic CAM, a sign of delayed maturation of the cerebellar cortex, fits well with the increased expression of the 5-HT2AR (see above), having an inhibitory role.…”

Section: Noradrenaline and Maturation Of The Cerebellar Cortexmentioning

confidence: 91%

“…Cisplatin treatment affects the active phase of Pc differentiation, interfering with the morphological and molecular events involved in dendrite growth, elimination of climbing fibre synapses on the somata, parallel fibre synaptogenesis, and formation of inhibitory contacts (Pisu et al, 2003(Pisu et al, , 2004Avella et al, 2006). Cell death in the EGL as well as cell migration from the EGL to IGL are altered by cisplatin administration (Pisu et al, 2005).…”

Section: Serotonin and Maturation Of The Cytoarchitecture Of The Cerementioning

confidence: 97%

Monoamine receptors and immature cerebellum cytoarchitecture after cisplatin injury

Roda

Avella

Pisu

et al. 2007

Journal of Chemical Neuroanatomy

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Reorganization of the rat cerebellar cortex during postnatal development following cisplatin treatment

Cited by 25 publications

References 82 publications

Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Postnatal Development of the Central Nervous System: Anomalies in the Formation of Cerebellum Fissures

Monoamine receptors and immature cerebellum cytoarchitecture after cisplatin injury

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