Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Bottone, Maria Grazia; Veronica, Dal Bo; Piccolini, Valeria Maria; Bottiroli, Giovanni; Pascali, Sandra Angelica De; Fanizzi, Francesco Paolo; Bernocchi, Graziella

doi:10.1016/j.jchemneu.2012.09.003

Cited by 11 publications

(6 citation statements)

References 60 publications

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“…From these experiments, it was deduced that HU-administration activates apoptotic cellular events, resulting in a substantial depletion of cells. Activation of apoptosis has also been reported in the EGL after hyperoxia [64], X-ray exposure [65] and the administration of some treatments, such as lead [66], ethanol [67] and platinum compounds [51]. In this context, the experimental model of HU-induced apoptosis reported here could provide a good system to study the apoptotic mechanisms in the developing cerebellum.…”

Section: Embryonic Effects Of Hu Exposure: Long-survival Experimentssupporting

confidence: 59%

“…In this context, it has been reported that several spontaneous murine mutations, including lurcher, staggerer, reeler and weaver cause a marked reduction in the volume and shape of the cerebellum due to the severe depletion of neurons [47][48][49]. In addition, it has also been indicated that the selective elimination of neuron precursors with X-irradiation [37], platinum compounds [50][51], impairment of the thyroid status [52], ethanol [53] and virus infection [54] produce an important reduction in size of the cerebellar cortex.…”

Section: Teratogenic Effects Of Hydroxyureamentioning

confidence: 99%

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An Animal Model to Assess the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought<strong> </strong>

Rodríguez-Vázquez¹,

Martí²

2018

Preprint

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The cytostatic agent hydroxyurea (HU) has proven to be beneficial for a variety of conditions in the disciplines of oncology, hematology, infectious disease and dermatology. It disrupts the S-phase of the cell cycle by inhibiting the ribonucleotide reductase enzyme, thus blocking the transformation of ribonucleotides into deoxyribonucleotides, a rate limiting step in DNA synthesis. HU is listed as an essential medicine by the World Health Organization. Several studies have indicated that HU is well tolerated and safe in pregnant women and very young pediatric patients. To our knowledge, only a few controlled studies about the adverse effects of HU therapy have been done in humans. Despite this, the prevalence of central nervous system abnormalities, including ischemic lesions and stenosis have been reported. This review will summarize and present the effects of HU-exposure on the prenatal and perinatal development of the rat cerebellar cortex and deep cerebellar nuclei neurons. Our results call for the necessity to better understand HU effects and define the administration of this drug to gestating women and young pediatric patients.

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Section: Embryonic Effects Of Hu Exposure: Long-survival Experimentssupporting

confidence: 59%

Section: Teratogenic Effects Of Hydroxyureamentioning

confidence: 99%

An Animal Model to Assess the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought<strong> </strong>

Rodríguez-Vázquez¹,

Martí²

2018

Preprint

View full text Add to dashboard Cite

show abstract

“…From these experiments, it was deduced that HU administration activates apoptotic cellular events, resulting in a substantial depletion of cells. Activation of apoptosis has also been reported in the EGL after hyperoxia [63], X-ray exposure [64] and the administration of some treatments, such as lead [65], ethanol [66] and platinum compounds [50]. In this context, the experimental model of HU-induced apoptosis reported here could provide a good system to study the apoptotic mechanisms in the developing cerebellum.…”

Section: Perinatal Effects Of Hu Exposure: Short-survival Experimentssupporting

confidence: 53%

“…In this context, it has been reported that several spontaneous murine mutations, including lurcher, staggerer, reeler and weaver cause a marked reduction in the volume and shape of the cerebellum due to the severe depletion of neurons [46,47,48]. In addition, it has also been indicated that the selective elimination of neuron precursors with X-irradiation [36], platinum compounds [49,50], impairment of the thyroid status [51], ethanol [52] and virus infection [53] produce an important reduction in size of the cerebellar cortex.…”

Section: Justifying the Choice Of The Cerebellum As A Model To Assmentioning

confidence: 99%

An Animal Model for Assessing the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought

Rodríguez-Vázquez¹,

Martí²

2018

IJMS

View full text Add to dashboard Cite

The cytostatic agent hydroxyurea (HU) has proven to be beneficial for a variety of conditions in the disciplines of oncology, hematology, infectious disease and dermatology. It disrupts the S phase of the cell cycle by inhibiting the ribonucleotide reductase enzyme, thus blocking the transformation of ribonucleotides into deoxyribonucleotides, a rate limiting step in DNA synthesis. HU is listed as an essential medicine by the World Health Organization. Several studies have indicated that HU is well tolerated and safe in pregnant women and very young pediatric patients. To our knowledge, only a few controlled studies on the adverse effects of HU therapy have been done in humans. Despite this, the prevalence of central nervous system abnormalities, including ischemic lesions and stenosis have been reported. This review will summarize and present the effects of HU exposure on the prenatal and perinatal development of the rat cerebellar cortex and deep cerebellar nuclei neurons. Our results call for the necessity to better understand HU effects and define the administration of this drug to gestating women and young pediatric patients.

show abstract

“…The possible neuroprotective role of other specific cellular molecules, such as cellular prion (PrPc), has been studied [ 121 ]. After PtAcacDMS treatment, with respect to the controls, changes were detected in PrPc and apoptotic proteins.…”

Section: Resultsmentioning

confidence: 99%

Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System

Bernocchi

Fanizzi

Pascali

et al. 2015

Toxics

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Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological complications especially in paediatric oncology patients with Central Nervous System (CNS) and non-CNS malignancies. To understand the toxicity mechanisms of platinum drugs at cellular and molecular levels in the immature brain, which appears more vulnerable to injury than in the adult one, we compared the effects in vivo of the most used platinum compounds, i.e., cisdichlorodiammineplatinum (cisplatin, cisPt), and the new [Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcacDMS). As models of developing brain areas, we have chosen the cerebellum and hippocampus dentate gyrus. Both areas show the neurogenesis events, from proliferation to differentiation and synaptogenesis, and therefore allow comparing the action of platinum compounds with DNA and non-DNA targets. Here, we focused on the changes in the intracellular calcium homeostasis within CNS architecture, using two immunohistochemical markers, the calcium buffer protein Calbindin and Plasma Membrane Calcium ATPase. From the comparison of the cisPt and PtAcacDMS effects, it emerges how essential the equilibrium and synergy between CB and PMCA1 is or how important the presence of at least one of them is to warrant the morphology and function of nervous tissue and limit neuroarchitecture damages, depending on the peculiar and intrinsic properties of the developing CNS areas.

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Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Cited by 11 publications

References 60 publications

An Animal Model to Assess the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought<strong> </strong>

An Animal Model to Assess the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought<strong> </strong>

An Animal Model for Assessing the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought

Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System

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