Monoamine receptors and immature cerebellum cytoarchitecture after cisplatin injury

Roda, Elisa; Avella, Debora; Pisu, Maria Bonaria; Bernocchi, Graziella

doi:10.1016/j.jchemneu.2006.11.001

Cited by 7 publications

(1 citation statement)

References 87 publications

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“…Apoptotic cell death in the EGL with concomitant alteration of migratory process, atrophy of Purkinje cell dendrite branches and formation of altered synaptic contacts were detected [ 114 ]. Our studies on the effects of cisPt on neurotransmitter molecules connected with the brain maturation, showed that neurotransmitters such as GABA, glutamate, and monoamines affected the cisPt-induced changes of developing cerebellum architecture [ 84 , 85 , 115 , 119 ], and therefore in the formation of synaptic contacts.…”

Section: Resultsmentioning

confidence: 99%

Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System

Bernocchi

Fanizzi

Pascali

et al. 2015

Toxics

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Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological complications especially in paediatric oncology patients with Central Nervous System (CNS) and non-CNS malignancies. To understand the toxicity mechanisms of platinum drugs at cellular and molecular levels in the immature brain, which appears more vulnerable to injury than in the adult one, we compared the effects in vivo of the most used platinum compounds, i.e., cisdichlorodiammineplatinum (cisplatin, cisPt), and the new [Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcacDMS). As models of developing brain areas, we have chosen the cerebellum and hippocampus dentate gyrus. Both areas show the neurogenesis events, from proliferation to differentiation and synaptogenesis, and therefore allow comparing the action of platinum compounds with DNA and non-DNA targets. Here, we focused on the changes in the intracellular calcium homeostasis within CNS architecture, using two immunohistochemical markers, the calcium buffer protein Calbindin and Plasma Membrane Calcium ATPase. From the comparison of the cisPt and PtAcacDMS effects, it emerges how essential the equilibrium and synergy between CB and PMCA1 is or how important the presence of at least one of them is to warrant the morphology and function of nervous tissue and limit neuroarchitecture damages, depending on the peculiar and intrinsic properties of the developing CNS areas.

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