Renal Transplantation with Kidneys Affected by Tumours

Khurram, Muhammad; Sanni, Aliu; Rix, D.; Talbot, David

doi:10.4061/2010/529080

Cited by 10 publications

(8 citation statements)

References 47 publications

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“…This may also explain why current evidence shows a relatively low recurrence rate from transplantation of resected kidney from small renal cancer donors [20]. A systematic literature review revealed 96 documented cases of renal transplants conducted with donor kidneys from small renal cancer patients, with no definite cancer recurrence [21].…”

Section: Discussionmentioning

confidence: 99%

Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation

Fu²,

Liu³

et al. 2013

PLoS ONE

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The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simulated organ preservation process. It was found that the viability and proliferation of malignant renal cells are inhibited much more than that of benign renal cells during prolonged organ preservation. The inhibition of proliferation in benign renal cells is fully reversible, while in malignant renal cancer cells is not fully reversible after a certain time. So potential residual renal cancer cells could be partly inhibited and eliminated by organ preservation process.

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Section: Discussionmentioning

confidence: 99%

Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation

Fu²,

Liu³

et al. 2013

PLoS ONE

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“…One such area is the use of kidneys containing small tumors after resection of the neoplasm. A report supports the feasibility of utilizing surgically restored cancerous kidneys [18]. In that report, the patients who had lost their kidney because of tumors supported the use of the kidneys (93%).…”

Section: Discussionmentioning

confidence: 81%

Gender Bias in Living Donor Kidney Transplantation in Japan: a Questionnaire Survey in Spousal Renal Donors

Takagi¹

2015

IJSSH

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Abstract-Living donor nephrectomy for renal transplantation has become widespread as surgical techniques. A questionnaire survey of living transplantation donors who gave a kidney to their spouses was conducted to determine their perceptions of living donor kidney transplantation. In this survey, 2 of 3 kidneys were donated by wives. In general, men are breadwinners in the family and women are more often expected to act as donors. From the responses to the question "How much was your intention to become a donor?," it was clear that wife-donors had lesser intention to donate than husband-donors. In other words, the decision of wife-donors was more influenced by others. Donors were also asked their opinions regarding transplantation of surgically restored cancerous kidneys. This is currently not allowed in Japan. From the result, wife-donors were more tolerant of restored kidney transplantation than husband-donors. Transplantation using a previously cancerous donor kidney may offer some relief of pressure placed on family members, particularly wives, to donate.Index Terms-Questionnaire survey, gender imbalance in living donor, donors' perceptions, restored kidney transplantation.

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“…Several studies reported the detection of allograft renal cancer after transplantation . In 1971, Tunner reported a case in which a kidney with renal cell carcinoma was transplanted to an ESRF patient without resection of the tumor.…”

Section: Resultsmentioning

confidence: 99%

Allotransplanting donor kidneys after resection of a small renal cancer or contralateral healthy kidneys from cadaveric donors with unilateral renal cancer: a systematic review

et al. 2013

Clinical Transplantation

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This systematic review summarizes evidence on allotransplantation of donor kidneys after resection of a small renal cancer or contralateral healthy kidneys from cadaveric donors with unilateral renal cancer. Eligible studies were identified by screening four bibliographic databases, contacting key authors, and analyzing the bibliographies of included studies. Two reviewers independently assessed the reports for inclusion and extracted data, which were summarized as a narrative review. In the 20 case report or case series studies included in the analysis, there were 97 documented cases of donor kidney transplantation after resection of small renal cancer without pathologically confirmed recurrence, whereas 22 cases used contralateral healthy kidneys from cadaveric donors with unilateral renal cancer with one case of cancer recurrence. These results suggest that the use of donor kidneys after resection of small renal cancer is associated with a relatively low cancer recurrence rate.

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Renal Transplantation with Kidneys Affected by Tumours

Cited by 10 publications

References 47 publications

Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation

Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation

Gender Bias in Living Donor Kidney Transplantation in Japan: a Questionnaire Survey in Spousal Renal Donors

Allotransplanting donor kidneys after resection of a small renal cancer or contralateral healthy kidneys from cadaveric donors with unilateral renal cancer: a systematic review

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