Allotransplanting donor kidneys after resection of a small renal cancer or contralateral healthy kidneys from cadaveric donors with unilateral renal cancer: a systematic review

Yu, Nengwang; Fu, Shuai; Fu, Zhihou; Meng, Jie; Xu, Zhonghua; Wang, Baocheng; Zhang, Aimin

doi:10.1111/ctr.12262

Cited by 11 publications

(8 citation statements)

References 33 publications

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“…Our results are in line with recent studies that have supported the feasibility of considering the use of organs from donors with small RCC resected prior to transplant. Yu et al found no evidence of RCC recurrence in 97 cases with pre‐transplant RCC resection. One example of recurrence occurred in 22 cases in which the contralateral kidney was used.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma suspected at time of organ donation 2008‐2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry

Pavlakis

Michaels

Tlusty³

et al. 2019

Clinical Transplantation

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All 179 reports to the OPTN of potential renal cell carcinoma (RCC) transmission from 1/1/2008 through 12/31/2016 were reviewed. Cases were divided into those with donor tumor known or suspected at time of transplant (N = 147 donors), and those in which tumor was initially found after transplant (N = 32). We sought to understand the risk of transplanting either the affected kidney, the contralateral kidney or non‐renal organs from donors with a suspected/confirmed unilateral RCC. In the case of RCC found prior to transplant, transplantation of 21 kidneys following excision of tumor, 47 contralateral kidneys and 198 non‐renal organs was performed. No cases of RCC transmission were documented in this population. An additional six cases of live donor kidney transplantation involving resection of RCC were reported, also without transmission. Six of 9 other recipients in whom the diagnosis of RCC became available after implantation underwent allograft nephrectomy and 3 received tumor resection. No recurrent RCC was documented. Given the low rate of transmission and available treatment options, consideration should be given to judicious use of organs from donors with small solitary RCC.

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Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma suspected at time of organ donation 2008‐2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry

Pavlakis

Michaels

Tlusty³

et al. 2019

Clinical Transplantation

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“…Kidney transplant by using a restored kidney graft after ex vivo excision of a tumour has been reported as a novel source [16,19–22,25]. The tumour was usually an incidental finding during deceased donor kidney procurement or live donor workup.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of tumour recurrence is associated with the tumour size and its Fuhrman grade. The kidney graft with a tumour at Fuhrman grade IV should not be recommended for transplantation as the high risk of tumour recurrence [21,25,33].…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Mou

et al. 2020

Transpl Int

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The aim of this study is to report long-term outcomes of kidney transplantation by using the kidney graft after a small tumour ex vivo excision. A structured programme was established to use the restored kidney graft from urological referral after radical nephrectomy. The criteria were defined as tumour size ≤3 cm, margin clear on frozen section and recipients aged ≥60 years or those on the urgent list for transplantation as a result of imminent lack of dialysis access. The recipients were followed up regularly for surveillance of tumour recurrence. Between February 2007 and February 2018, 28 recipients had kidney transplantation by using the restored kidney grafts. The tumour size was 2.6 AE 0.7 cm. The follow-up was median 7 years without evidence of tumour recurrence. The patient and graft survival was satisfactory. Kidney transplantation by using restored kidneys after a small tumour excision is a novel source for selected recipients. The long-term patient and graft survival is satisfactory. Although there is a risk of tumour recurrence, it is rare event. Together with literature review, we would support use of kidney graft after a small tumour excision for selected recipients.

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“…Transplantation is associated with a low but unavoidable risk of cancer transmission [1–3]. Physical examination and CT scan are routinely performed to detect unknown malignancy before donation, but some cancers, such as gallbladder cancer (GBC), can be difficult to rule out.…”

Section: Variables Case 1 Case 2 Casementioning

confidence: 99%

Accidental transplantation of hepatic graft with incidental T2 gallbladder carcinoma: a report of 3 cases

et al. 2020

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Allotransplanting donor kidneys after resection of a small renal cancer or contralateral healthy kidneys from cadaveric donors with unilateral renal cancer: a systematic review

Cited by 11 publications

References 33 publications

Renal cell carcinoma suspected at time of organ donation 2008‐2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry

Renal cell carcinoma suspected at time of organ donation 2008‐2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry

Long‐term outcome of kidney transplant by using restored kidney grafts after tumour ex vivo excision – a prospective study

Accidental transplantation of hepatic graft with incidental T2 gallbladder carcinoma: a report of 3 cases

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