Renal peroxidative changes mediated by oxalate: The protective role of fucoidan

Veena, Coothan Kandaswamy; Josephine, Anthony; Preetha, S.; Varalakshmi, P.; Sundarapandiyan, R.

doi:10.1016/j.lfs.2006.06.014

Cited by 52 publications

(35 citation statements)

References 41 publications

(36 reference statements)

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“…The DHA crystals could enhance the production of peroxides and toxic superoxide anion radicals (Veena et al, 2006). Free radicals interact with renal epithelia that damages the renal membranes, and result in the tubules dysfunction or damage (Grases et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease

Wang

Hou

et al. 2012

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease

Wang

Hou

et al. 2012

Journal of Ethnopharmacology

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“…In recent years, fucoidan or FCSPs from seaweed biomass have been the subject of many scientific studies aiming at assessing their potential biological activities including antitumor and immunomodulatory [40–42], antivirus [43], antithrombotic and anticoagulant [44], anti-inflammatory [45], and antioxidant effects [46], as well as their effects against various renal [47], hepatic [48] and uropathic disorders [49]. …”

Section: Bioactivity Of Fucoidan or Fcspsmentioning

confidence: 99%

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

2011

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Seaweeds—or marine macroalgae—notably brown seaweeds in the class Phaeophyceae, contain fucoidan. Fucoidan designates a group of certain fucose-containing sulfated polysaccharides (FCSPs) that have a backbone built of (1→3)-linked α-l-fucopyranosyl or of alternating (1→3)- and (1→4)-linked α-l-fucopyranosyl residues, but also include sulfated galactofucans with backbones built of (1→6)-β-d-galacto- and/or (1→2)-β-d-mannopyranosyl units with fucose or fuco-oligosaccharide branching, and/or glucuronic acid, xylose or glucose substitutions. These FCSPs offer several potentially beneficial bioactive functions for humans. The bioactive properties may vary depending on the source of seaweed, the compositional and structural traits, the content (charge density), distribution, and bonding of the sulfate substitutions, and the purity of the FCSP product. The preservation of the structural integrity of the FCSP molecules essentially depends on the extraction methodology which has a crucial, but partly overlooked, significance for obtaining the relevant structural features required for specific biological activities and for elucidating structure-function relations. The aim of this review is to provide information on the most recent developments in the chemistry of fucoidan/FCSPs emphasizing the significance of different extraction techniques for the structural composition and biological activity with particular focus on sulfate groups.

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“…Zhang et al [6] reported that sulfated polysaccharides play important roles as free-radical scavengers and antioxidants, which can prevent oxidative damage in living organisms. The low molecular weight polysaccharides heparin and fucoidan provided protection against oxalate (Ox)-induced oxidative renal injury [3,7]. Ox and calcium oxalate monohydrate (COM) induce the generation of free radicals, which are major mediators of the pathologic consequences of the formation of kidney stones [8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization

Zhang

Wang

et al. 2012

Marine Drugs

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Abstract:We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calcium oxalate monohydrate crystals, using trisodium citrate as a positive control. We assessed antioxidant activities of SGP by determining its reducing power, its ability to scavenge superoxide radicals, and its activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The nucleation inhibition ratio of trisodium citrate and SGP was 58.5 and 69.2%, respectively, and crystal aggregation was inhibited by 71.4 and 76.8%, respectively. Increasing concentrations of SGP resulted in increased scavenging of superoxide anions and DPPH radicals (IC 50 = 1.9 and 0.6 mg/mL, respectively). These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization and its antioxidant properties.Keywords: calcium oxalate crystallization; antioxidant; polysaccharide; Sargassum graminifolium OPEN ACCESSMar. Drugs 2012, 10 120 Abbreviations SGP, polysaccharide from Sargassum graminifolium; IR, infrared spectrum; DPPH, 1,1-diphenyl-2-picrylhydrazyl free radical; Ox, oxalate; CaOx, calcium oxalate; OD, optical density; S N , maximum increase of optical density with time; S A , rate of aggregation derived from the maximum decrease in optical density; t max , maximum time; COM, Calcium oxalate monohydrate; COD, Calcium oxalate dehydrate; COT, Calcium oxalate trihydrate.

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Renal peroxidative changes mediated by oxalate: The protective role of fucoidan

Cited by 52 publications

References 41 publications

Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease

Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization

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