Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease

Wang, Jing; Wang, Feng; Hou, Yun; Zhang, Hong; Zhang, Quanbin

doi:10.1016/j.jep.2011.12.022

Cited by 67 publications

(33 citation statements)

References 29 publications

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“…Besides, serum uric acid was found to be significantly increased (p<0.05) in rats treated with only gentamicin; whereas treatment with fucoidan was found to protect the rats from such effects of gentamicin. Similar results were also observed by Wang et al (44) and Zhang et al (48).…”

Section: Discussionsupporting

confidence: 91%

“…Sulfated polysaccharides protect kidney by independent mechanisms of glomerular haemodynamic changes that have been shown in many experiments (10,44). It could be probably due to its inhibition of mesangial cell proliferation.…”

Section: Discussionmentioning

confidence: 88%

“…It could be probably due to its inhibition of mesangial cell proliferation. Modulation of synthesis and composition of the extracellular matrix may play a role as well (10,44). Besides, sulfated polysaccharides were mediated by replacing the electronegative content of the glomerular cells (9,16,44,48).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, sulfated polysaccharides were mediated by replacing the electronegative content of the glomerular cells (9,16,44,48). Wang et al (44) reported that the benzoylate group substituted in fucoidan could enhance the electronegativity of fucoidan, and they could replace the electronegative content of glomerular cells more easily.…”

Section: Discussionmentioning

confidence: 99%

“…People use them as a traditional medicine for curing edema, a symptom of kidney diseases, for more than thousand years (44,47). There have been many studies performed in recent years related with fucoidan which is indicated for protective effect in kidney diseases (9,44,48).…”

Section: Introductionmentioning

confidence: 99%

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The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

MERT¹

2018

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Fucoidan is a polysaccharide with high viscosity and mucilage, which contains significant proportion of sulphate ester group and L-fucose. It is present in intercellular spaces of brown algae. This study aimed to investigate the effect of fucoidan on some biochemical parameters and kidney tissues in nephrotoxicity induced by GM in rats. The rats used in the study were randomly divided into 4 groups. Each group had 7 rats as control, fucoidan, GM and GM+fucoidan. Blood samples were taken after 24 hours from the end of experiment which lasted eight days. Creatinine, BUN, uric acid, glucose, triglycerides, total cholesterol, VLDL, HDL, total bilirubin levels and ALT, AST, ALP, LDH, CK, amylase activities were assayed by an autoanalyser. The kidney tissues were examined histopathologically. In GM+fucoidan group, creatinine (p<0.001), BUN (p<0.001), uric acid (p<0.05), triglycerides (p<0.05), VLDL (p<0.05), AST (p<0.001), ALP (p<0.05), LDH (p<0.001), CK (p<0.01) levels statistically decreased, however HDL (p<0.05) level increased when compared to GM group. As conclusion, it can be said that administering fucoidan during GM toxicity decreases the nephrotoxicity damage. Considering biochemical parameters and histopathological findings, fucoidan can be suggested as a protective agent for kidneys in nephrotoxicity induced rats.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 88%