Renal pathological findings in infective endocarditis

Majumdar, Arghya; Chowdhary, Saqib; Ferreira, M. A.; Hammond, Lisekle A.; Howie, Alexander J.; Lipkin, Graham; Littler, W. A.

doi:10.1093/ndt/15.11.1782

Cited by 133 publications

(104 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ostra niewydolność nerek występuje u ok. 6-30% pacjentów [291,292,294,295]. Etiologia często jest wieloczynnikowa [296,297]: (i) kompleksy immunologiczne i naczyniowe kłębuszkowe zapalenie nerek; (ii) zawał nerki, głównie na skutek zatorów septycznych, występujący w dowolnym czasie w przebiegu IZW; (iii) pogorszenie funkcji hemodynamicznych w przypadku HF lub ciężkiej posocznicy albo w okresie pooperacyjnym; (iv) nefrotoksyczność antybiotyków (ostre śródmiąższowe zapalenie nerek), wyraźnie związane ze stosowaniem aminoglikozydów, wankomycyny (toksyczne działanie synergistyczne z aminoglikozydami), a nawet benzylopenicyliny w wysokich dawkach; (v) nefrotoksyczność środków kontrastowych stosowanych w diagnostyce obrazowej.…”

Section: Ostra Niewydolność Nerekunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

129

210

View full text Add to dashboard Cite

Section: Ostra Niewydolność Nerekunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

129

210

View full text Add to dashboard Cite

“…Key histopathologic findings include emboli, interstitial nephritis, crescentic GN, immune complex-mediated GN, and acute tubular necrosis [13]. Our patient exhibited focal crescentic GN with focal mesangial GN.…”

Section: Discussionmentioning

confidence: 61%

C-ANCA-positive glomerulonephritis associated with subacute infective endocarditis caused by Bartonella infection

Kim

Jang

Lee

et al. 2017

Yeungnam Univ J Med

View full text Add to dashboard Cite

Glomerulonephritis (GN) is sometimes associated with infective endocarditis (IE). Bartonella endocarditis is difficult to diagnose because it is rare and cannot be detected by blood culture. This is the first report of cytoplasmic anti-neutrophil cytoplasmic antibody-positive subacute endocarditis-associated GN caused by Bartonella infection in South Korea. A 67-year-old man was hospitalized due to azotemia. He complained of weight loss and anorexia for 6 months. A diagnosis of IE was made based upon echocardiographic detection of vegetations on the mitral and aortic valves and a Bartonella antibody titer of 1:2,048. Renal histology identified focal crescentic GN. Azotemia and proteinuria improved after doxycycline and rifampin treatment combining with steroid therapy.

show abstract

“…It is well known that endocarditis can cause glomerulonephritis, the commonest type being vasculitic, without deposition of immune complexes in the glomeruli, 4 contrary to the commonly held view of hypocomplementemic immune complex deposition renal injury. This case emphasizes that all cases of pauci-immune necrotizing crescentic glomerulonephritis should be assessed fully to exclude endocarditis.…”

Section: Discussionmentioning

confidence: 77%

Fortuitous Vasculitis

et al. 2012

View full text Add to dashboard Cite

A 43-year-old man with a cardiac device for dilated cardiomyopathy presented with fever, night sweats, and weight loss. Investigations revealed pancytopenia, acute renal failure, abnormal lung function, and raised inflammatory markers. A renal biopsy demonstrated pauci-immune necrotizing crescentic glomerulonephritis. He was diagnosed with pulmonary-renal antineutrophil cytoplasmic antibody-negative systemic small vessel vasculitis. He commenced immunosuppression with prednisolone and cyclophosphamide with recovery from pancytopenia and improvement in renal function 3 months later. Subsequently, a bone marrow culture grew Mycobacterium fortuitum. Isolation on repeat peripheral mycobacterial blood cultures prompted treatment with ciprofloxacin and clarithromycin. Four months later, he presented with neutropenic sepsis, influenza A/H1N1, and Aspergillus flavus pneumonia. Despite treatment he deteriorated. A transthoracic echocardiogram revealed a vegetation on the right ventricular pacing wire. The device was removed. The vegetation revealed acid and alcohol fast bacilli on Ziehl-Neelsen staining and grew M. fortuitum on culture, sensitive to ciprofloxacin and clarithromycin. Despite device removal and antimicrobial therapy, the patient succumbed to treatment-related complications. The association between glomerulonephritis and endocarditis is well known; however, this is the first case to our knowledge describing pauci-immune necrotizing crescentic glomerulonephritis in the context of M. fortuitum endocarditis. Clinicians should maintain a high index of suspicion for endocarditis in patients with a cardiac device who present with fever and pauci-immune necrotizing crescentic glomerulonephritis. Patients should be investigated with mycobacterial blood cultures, at least three sets of standard blood cultures and transthoracic and transesophageal echocardiography. Clinicians should beware the perils of immunosuppression in the face of an occult sepsis.

show abstract

Renal pathological findings in infective endocarditis

Cited by 133 publications

References 17 publications

2015 ESC Guidelines for the management of infective endocarditis

2015 ESC Guidelines for the management of infective endocarditis

C-ANCA-positive glomerulonephritis associated with subacute infective endocarditis caused by Bartonella infection

Fortuitous Vasculitis

Contact Info

Product

Resources

About