Renal histamine H1 and H2 receptors: characterization and functional significance

Banks, Robert O.; Fondacaro, Joseph D.; Schwaiger, M; Jacobson, Eugene D.

doi:10.1152/ajprenal.1978.235.6.f570

Cited by 23 publications

(36 citation statements)

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“…In the kidney of diabetic rats, histamine was increased compared with controls [2]. Basically, histamine has been reported to regulate the renal microcirculation, to increase salt and water excretion [3][4][5], decrease the ultrafiltration coefficient by reducing the total filtration surface area [4], and increase renin release [6].…”

Section: Introductionmentioning

confidence: 98%

H3 receptor renal expression in normal and diabetic rats

et al. 2015

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Section: Introductionmentioning

confidence: 98%

H3 receptor renal expression in normal and diabetic rats

et al. 2015

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“…Indeed, in the kidney of diabetic rats, histamine was increased compared with controls [6,7]. Independent studies indicate that histamine regulates the renal microcirculation, by increasing salt and water excretion [8][9][10], decreasing the ultrafiltration coefficient by reducing the total filtration surface area [10], and increasing renin release [11].…”

Section: Introductionmentioning

confidence: 99%

Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation

et al. 2015

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Objective and design The aim of this study is to evaluate the expression of the histamine receptors, particularly focusing on the H 4 R in human renal tubules. MaterialThe ex-vivo evaluation was carried on specimens from human renal cortex. Primary and immortalized tubular epithelial cells (TECs) and the HK-2 cell line were used as in vitro models.Treatment Cells were pretreated for 10 min with chlorfeniramine maleate 10 µM (H 1 R antagonist), ranitidine 10 µM (H 2 R antagonist), GSK189254 1 µM (H 3 R antagonist) or JNJ7777120 10 µM (H 4 R antagonist), and then exposed to histamine (3 pM -10 nM) for 30 min. MethodsThe ex-vivo evaluation on specimens from human renal cortex was performed by immunohistochemistry. The expression of histamine receptors on primary and immortalized TECs and the HK-2 cell line was evaluated at both gene (RT-PCR) and protein (immunocytofluorescence) levels. The pharmacological analysis was performed by TR-FRET measurements of second messenger (IP3 and cAMP) production induced by histamine with or without the selective antagonists.Results Our data revealed the presence of all histamine receptors in human tubules; however, only TECs expressed all the receptors. Indeed, histamine elicited a sigmoid dose-response curve for IP 3 production, shifted to the right by chlorpheniramine maleate, and elicited a double bell-shaped curve for cAMP production, partially suppressed by the selective H 2 R, H 3 R and H 4 R antagonists when each added alone, and completely ablated when combined together.Conclusions Herein, we report the identification of all four histamine receptors in human renal tubules.

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“…In in vivo studies, infusion of histamine into the renal arteries of dogs resulted in renal vasodilatation, diuresis, natriuresis but no change in glomerular filtration rate (O'Brien & Williamson, 1971). Recently Banks, Fondacaro, Schwaiger & Jacobson (1978) have demonstrated that the renal vasculature contains both Hl-and H2-receptors and that these receptors have different effects on renal function even though both receptors are involved in renal vasodilatation.…”

Section: Introductionmentioning

confidence: 99%

The role of histamine receptors in the release of renin

Gerber

Nies

1983

British J Pharmacology

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1 The effect of intrarenal histamine, dimaprit (H2-agonist) and 2-(2-pyridyl) ethylamine (Hl-agonist) on renin release was examined in anaesthetized dogs.2 In dogs with intact kidneys, histamine and dimaprit administration resulted in renal vasodilatation, a two fold increase in urinary sodium excretion, and no change in renal renin release. 2(2-Pyridyl) ethylamine administration resulted in renal vasodilatation, a 25% decrease in urinary sodium excretion and a significant increase in renin release. 3 In dogs with non-filtering kidneys, dimaprit administration resulted in renal vasodilatation and a significant increase in renin release, while 2(2-pyridyl) ethylamine administration resulted in renal vasodilatation but no change in renin release. 4 Our data suggest that histamine is a potential participant in the release of renin through stimulation of H2-receptors, but it is a weak agonist. 5In addition, the direct effect of histamine analogues on renin release is modulated by their effects on electrolyte excretion probably by influencing the renal chemoreceptor release of renin mediated by the macula densa.

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Renal histamine H1 and H2 receptors: characterization and functional significance

Cited by 23 publications

References 0 publications

H3 receptor renal expression in normal and diabetic rats

H3 receptor renal expression in normal and diabetic rats

Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation

The role of histamine receptors in the release of renin

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