H3 receptor renal expression in normal and diabetic rats

Pini, Alessandro; Chazot, Paul L.; Veglia, Eleonora; Moggio, Aldo; Rosa, Arianna Carolina

doi:10.1007/s00011-015-0808-y

Cited by 14 publications

(12 citation statements)

References 12 publications

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“…However, it is noteworthy that histamine H 3 and H 4 receptors are overexpressed in kidneys of STZ‐pretreated (diabetic) rats, most probably as a compensatory mechanism for the cardiovascular autonomic neuropathy produced in individuals with diabetes …”

Section: Discussionmentioning

confidence: 99%

Differential cardiac sympatho‐inhibitory responses produced by the agonists B‐HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats

Rivera‐Mancilla

Altamirano-Espinoza

Manrique-Maldonado

et al. 2018

Clin Exp Pharma Physio

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This study compared the cardiac sympatho-inhibitory responses produced by agonists at α -adrenergic (B-HT 933), dopamine D -like (quinpirole) and histamine H /H (immepip) receptors between normoglycaemic and streptozotocin-pretreated (diabetic) pithed rats. Intravenous (i.v.) continuous infusions of B-HT 933, quinpirole or immepip were used in normoglycaemic and diabetic pithed rats to analyse their sympatho-inhibitory effects on the electrically-stimulated cardioaccelerator sympathetic outflow. Both in normoglycaemic and diabetic animals, B-HT 933 (until 100 μg/kg per minute) and quinpirole (until 10 μg/kg per minute) inhibited the tachycardic responses to electrical sympathetic stimulation, but not those to i.v. bolus of exogenous noradrenaline. These sympatho-inhibitory responses were more pronounced in diabetic than in normoglycaemic animals. Accordingly, the areas under the curve for 100 μg/kg per minute B-HT 933 and 10 μg/kg per minute quinpirole in diabetic rats (1065 ± 70 and 920 ± 35, respectively) were significantly smaller (P < .05) than those in normoglycaemic rats (1220 ± 45 and 1360 ± 42, respectively). In contrast, immepip infusions produced cardiac sympatho-inhibition in normoglycaemic (until 10 μg/kg per minute), but not in diabetic (until 100 μg/kg per minute) animals. Our results suggest that in diabetic pithed rats: (i) the more pronounced cardiac sympatho-inhibition to B-HT 933 and quinpirole may be probably due to up-regulation of α -adrenergic and dopamine D -like receptors, respectively; (ii) the histamine H /H receptors do not seem to play a sympatho-inhibitory role; and (iii) there is a differential participation of α -adrenergic and dopamine D -like receptors, which may certainly represent therapeutic targets for the treatment of diabetic complications such as cardiovascular autonomic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Differential cardiac sympatho‐inhibitory responses produced by the agonists B‐HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats

Rivera‐Mancilla

Altamirano-Espinoza

Manrique-Maldonado

et al. 2018

Clin Exp Pharma Physio

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“…The expression of H 1 and H 2 receptors on renal vessels has long been established (Banks, Fondacaro, Schwaiger, & Jacobson, 1978). More recently, the use of both primary and immortalised renal cell types from different mammals (Table 1) allowed to identify not only the H 1 receptor and H 2 receptor, but also the more recently discovered H 3 receptor and H 4 receptor, in the nephron and collecting ducts (Pini et al, 2015; Rosa et al, 2013; Veglia et al, 2015, 2016). The differential distribution of histamine receptors in the nephron and collecting duct is illustrated Figure 1 and Table 1.…”

Section: The Histaminergic Machinery In the Kidneysmentioning

confidence: 99%

“…Differential histamine receptor distribution in the mammalian nephron and collecting duct. Histamine receptors topology within the mammalian kidney based on current knowledge (Pini et al, 2015; Rosa et al, 2013; Sedor & Abboud, 1984; Sedor & Abboud, 1985; Veglia et al, 2015, 2016). H 1 and H 2 receptors have been identified within the renal corpuscle (H 1 receptors (H 1 R) in the glomerulus and H 2 receptors (H 2 R) in glomerulus and in glomerular capsule) and in the distal tubule.…”

Section: The Histaminergic Machinery In the Kidneysmentioning

confidence: 99%

“…The data by immunoassay were confirmed in humans by functional assays, evaluating cAMP accumulation following histamine challenge alone or with histamine receptor selective antagonists (Veglia et al, 2015). The H 3 receptor has surprisingly been found on the principal cells of the collecting duct, both in humans (Veglia et al, 2015) and in rats (Pini et al, 2015). Again, the data were obtained by both immunodetection and gene expression in both ex vivo and in vitro studies (Pini et al, 2015; Veglia et al, 2015) and were confirmed in vitro on human renal cells (Veglia et al, 2015), as described above.…”

Section: The Histaminergic Machinery In the Kidneysmentioning

confidence: 99%

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Histamine in the kidneys: what is its role in renal pathophysiology?

Grange

Gurrieri

Verta

et al. 2019

British J Pharmacology

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Starting with a role for histamine role in renal haemodynamics, evidence has accumulated, over time, suggesting a wider range of actions on renal function and this has renewed interest in the pathophysiological role of histamine in the kidney. Here we provide an up-to-date review of this topic. As the kidney expresses enzymes that synthesize and metabolise histamine, along with its receptors, all the components for histaminergic transmission are present in this tissue. The distribution of histamine receptors matches a wide range of effects. We address the questions of the redundancy of H 1 and H 2 receptors in renal haemodynamics, the complementary role of H 1 and H 4 receptors in renal filtration and reabsorption, and the dichotomy between local and neuronal H 1 and H 3 receptors. Experimental models of renal disease raise the possibility of new therapeutic approaches based on histamine. The effects of histamine on renal function are not yet fully understood and their elucidation is still ongoing. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit

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“…Histamine exerts its biological activity via the interaction with four distinct G protein-coupled histamine receptors. Among these histamine receptor subtypes, H1 and H2 are expressed in the hearts and kidneys, and H3 is expressed in the ending of sympathetic nerves in these tissues (32,33). With regard to the relationship between histamine receptor blockers and cardiovascular disease, it has been shown that H2B can attenuate the ischemia and reperfusion induced in the myocardia of mice (34) and has improved the clinical condition of heart failure in humans (35).…”

Section: Discussionmentioning

confidence: 99%

Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming

Noguchi

Ishida

Kim

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Heart failure and chronic kidney disease are major causes of morbidity and mortality internationally. Although these dysfunctions are common and frequently coexist, the factors involved in their relationship in cardiorenal regulation are still largely unknown, mainly due to a lack of detailed molecular targets. Here, we found the increased plasma histamine in a preclinical mouse model of severe cardiac dysfunction, that had been cotreated with angiotensin II (Ang II), nephrectomy, and salt (ANS). The ANS mice exhibited impaired renal function accompanied with heart failure, and histamine depletion, by the genetic inactivation of histidine decarboxylase in mice, exacerbated the ANS-induced cardiac and renal abnormalities, including the reduction of left ventricular fractional shortening and renal glomerular and tubular injuries. Interestingly, while the pharmacological inhibition of the histamine receptor H3 facilitated heart failure and kidney injury in ANS mice, administration of the H3 agonist immethridine (Imm) was protective against cardiorenal damages. Transcriptome analysis of the kidney and biochemical examinations using blood samples illustrated that the increased inflammation in ANS mice was alleviated by Imm. Our results extend the pharmacological use of H3 agonists beyond the initial purposes of its drug development for neurogenerative diseases and have implications for therapeutic potential of H3 agonists that invoke the anti-inflammatory gene expression programming against cardiorenal damages.

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H3 receptor renal expression in normal and diabetic rats

Abstract: Introduction

Cited by 14 publications

References 12 publications

Differential cardiac sympatho‐inhibitory responses produced by the agonists B‐HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats

Differential cardiac sympatho‐inhibitory responses produced by the agonists B‐HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats

Histamine in the kidneys: what is its role in renal pathophysiology?

Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming

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