The role of histamine receptors in the release of renin

Abstract

1 The effect of intrarenal histamine, dimaprit (H2-agonist) and 2-(2-pyridyl) ethylamine (Hl-agonist) on renin release was examined in anaesthetized dogs.2 In dogs with intact kidneys, histamine and dimaprit administration resulted in renal vasodilatation, a two fold increase in urinary sodium excretion, and no change in renal renin release. 2(2-Pyridyl) ethylamine administration resulted in renal vasodilatation, a 25% decrease in urinary sodium excretion and a significant increase in renin release. 3 In dogs with non-filtering kidneys, dimaprit administration resulted in renal vasodilatation and a significant increase in renin release, while 2(2-pyridyl) ethylamine administration resulted in renal vasodilatation but no change in renin release. 4 Our data suggest that histamine is a potential participant in the release of renin through stimulation of H2-receptors, but it is a weak agonist. 5In addition, the direct effect of histamine analogues on renin release is modulated by their effects on electrolyte excretion probably by influencing the renal chemoreceptor release of renin mediated by the macula densa.

The Role of Histamine H₁ and H₂ Receptors in the Canine Kidney

“…These findings arc in agreement with those of sev eral investigators [1,3,9,10]. H , receptors also appeared to mediate the effect of hista mine on FEN (1.…”

“…However, if the FENa were dependent on hemodynamic changes, then tripelennamine alone should also have reduced FENa. Gerber and Nies [3] recently reported that PEA significantly in creased RBF but decreased urinary sodium excretion. They suggested that the slight but nonsignificant decline in G F R may have been partly responsible for the decrease in urinary sodium excretion.…”

“…have been shown to mediate the effects of histamine on renal hemodynamics [2], Little is known about the role of H, and H , receptors in mediating the effects of his tamine on tubular function. Tripelennarnine has been found to antagonize hista mine-induced increases in urine flow arid sodium excretion, an effect which was attrib uted to inhibition of histamine-induced renal vasodilation [8], Most recently it was reported that PEA reduced urine flow and chloride excretion [1] as well as urinary so dium excretion [3], whereas dimaprit en hanced urine flow and chloride excretion [1]-…”

“…On the other hand the H 2 agonist, dimaprit. has been shown to produce a rise in RBF [1,3,9,10]. while the H,-receptor antagonist, cimetidine, partially blocked histamine-induced increases in RBF [1.…”

“…In anesthetized dogs, the H, agonist. 2-(2-pyridyhethylamine (PEA), has been shown to produce either an increase [1,3] or no change [10] in total renal blood How (RBF). and histamine-induced increases in RBF have been partially antagonized [1,8] or completely unaffected [10] by the H r receptor antagonist, tripelennamine.…”