Renal Function Predicts Outcomes in Patients with Ischaemic Stroke and Haemorrhagic Stroke

Snarska, Katarzyna; Kapica-Topczewska, Katarzyna; Bachórzewska−Gajewska, Hanna; Małyszko, Jolanta

doi:10.1159/000443444

Cited by 27 publications

(23 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, serum OX40L showed positive correlation with serum creatinine, an indicator of renal function and prognosis of ischemic stroke, which was also reported by other scholars in patients with systemic lupus erythematosus. [ 18 , 19 ] We also found that serum OX40L positively correlated with a proinflammatory cytokine hs-CRP. OX40L also demonstrated positive correlation with hs-CRP in acute coronary syndrome patients, and both these 2 proteins involve the pathogenesis of atherosclerosis, and associated with disease severity and progression.…”

Section: Discussionsupporting

confidence: 53%

High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction

Mao

Chen

et al. 2020

Medicine

View full text Add to dashboard Cite

OX40 ligand (OX40L) is a member of tumor necrosis factors (TNF)/TNFR superfamily and is mainly expressed in activated T cells and participates in various inflammatory reactions. However, it remains unclear about the role of serum OX40L as a biomarker of cerebral infarction (CI). This study aimed to explore the possibility of serum OX40L as a meaningful predictor in mortality of CI. Severe CI patients were included to collect clinicopathological and laboratory data and measure serum OX40L level. Patients were followed up after discharge and 60-day survival rate was used as the study endpoint. The results showed that of all 294 patients, 123 (41.8%) died within 60 days after admission. Serum OX40L levels were significantly higher in patients with severe CI compared to healthy controls, and were significantly higher in nonsurvivors compared to survivors ( P < .05). The levels of OX40L were correlated with Glasgow Coma Scale score, serum creatinine and high-sensitive C-reactive protein. Multivariate logistic regression analysis showed that serum OX40L level was an independent prognostic factor for 60-day mortality, after control of pulmonary infection, glasgow coma scale score and high-sensitive C-reactive protein (odds ratio = 1.089; 95% confidence interval = 1.053–1.126; P < .001). The receiver operating characteristic (ROC) curve was used to predict the best cut-off of serum OX40L for 60-day survival as 35.5 ng/mL. Patients with high serum OX40L levels (>35.5 ng/mL) had a significantly higher mortality within 60 days (hazard ratio = 2.885; 95% confidence interval = 1.901–4.378). In conclusion, OX40L is a serum biomarker of patients with CI and associated with severity and mortality of this disease.

show abstract

Section: Discussionsupporting

confidence: 53%

High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction

Mao

Chen

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

“…Snarska K. с соавт. отметили в своем исследовании, что в группе пациентов с летальным исходом независимо от типа инсульта были более высокий уровень сывороточного креатинина и низкие показатели СКФ [41]. В нашем исследовании было отмечено статистическое значимое влияние снижения СКФ на госпитальную летальность пациентов с ишемическим инсультом и сопутствующей ФП (ОШ=5,35; 95 % ДИ: 1,45-19,7; p=0,04).…”

Section: Discussionunclassified

Clinical and demographic features of patients with stroke and atrial fibrillation

Акпанова

Berkinbayev

Ospanova

et al. 2018

CARDIO

View full text Add to dashboard Cite

Резюме Актуальность. Инсульт занимает 2-е место среди всех причин кардиоваскулярной смертности и 1-е место по смертности и инвалидизации среди других заболеваний нервной системы. В настоящее время фибрилляция предсердий (ФП) является общепризнанным независимым ФР развития ишемического инсульта, она увеличивает риск неблагоприятного исхода в 5 раз. Профилактика инсульта на сегодняшний день является сложной медико-социальной задачей. Цель. Изучение распространенности ФП среди пациентов с инсультом / транзиторной ишемической атакой (ТИА) и проводимой антикоагулянтной терапии до госпитализации. Материалы и методы. Проведен ретроспективный анализ историй болезни пациентов с диагнозом острое нарушение мозгового кровообращения и ТИА, получавших лечение в период с января 2013 г. по декабрь 2015 г. (n=7921). Из них было отобрано 849 историй болезни пациентов с сопутствующим диагнозом ФП. Результаты. Частота ФП у пациентов с инсультом / ТИА составила 10,72 %. При оценке риска по шкале CHA 2 DS 2-VASc доля пациентов низкого риска (0 баллов) составила 0,8 %, промежуточного риска (1 балл)-5,3 %, высокого риска (≥2 баллов)-93,8 %; профилактику тромбоэмболических осложнений получали 4,7 % пациентов с ФП. Летальность пациентов с ФП и инсультом / ТИА составила 15,78 %, тогда как у пациентов без ФП госпитальная летальность составила 7,01 %. Таким образом, ФП является статистически значимым ФР госпитальной летальности среди пациентов с инсультом / ТИА (отношение шансов 2,485; 95 % доверительный интервал 2,023-3,053; p<0,001;). Обнаружено влияние на внутригоспитальную летальность пациентов с ишемическим инсультом и сопутствующей ФП таких факторов, как тяжелая ХСН, СД 2 типа, периферические тромбозы, чрескожное коронарное вмешательство в анамнезе, онкологические заболевания, снижение скорости клубочковой фильтрации. Заключение. Отмечены влияние ФП на госпитальную летальность пациентов с ишемическим инсультом и низкий охват профилактической антикоагулянтной терапией пациентов с ФП.

show abstract

“…However, the findings within these studies have not been consistent. For instance, Luo et al reported a higher risk of death due to CKD in ischemic stroke patients compared to haemorrhagic stroke [3], while Snarska et al reported higher risk in haemorrhagic stroke [4]. The aim of the current study is therefore to evaluate the association between CKD and stroke outcomes by stroke type.…”

Section: Introductionmentioning

confidence: 91%

Association of chronic kidney disease with outcomes in acute stroke

et al. 2020

View full text Add to dashboard Cite

Previous studies have found an association between chronic kidney disease and poor outcomes in stroke patients. However, there is a paucity of literature evaluating this association by stroke type. We therefore aimed to explore the association between CKD and stroke outcomes according to type of stroke. The data consisting of 594,681 stroke patients were acquired from Universal Coverage Health Security Insurance Scheme Database in Thailand. Binary logistic regression was used to assess the relationship of CKD and outcomes, which were as follows; in-hospital mortality, long length of stay (>3 days), pneumonia, sepsis, respiratory failure and myocardial infarction. Results: after fully adjusting for covariates, CKD was associated with increased odds of in-hospital mortality in patients with ischemic (OR 1.32; 95% CI = 1.27-1.38), haemorrhagic (OR 1.31; 95% CI = 1.24-1.39), and other undetermined stroke type (OR 1.44; 95% CI = 1.21-1.73). CKD was found to be associated with increased odds of pneumonia, sepsis, respiratory failure and myocardial infarction in ischaemic stroke. While CKD was found to be associated with increase odds of sepsis, respiratory failure, and myocardial infarction, decrease odds of pneumonia was observed in patients with haemorrhagic stroke. In other undetermined stroke type, CKD was found to only be associated with increase odds of sepsis and respiratory failure, while there is no significant association of CKD and increase or decrease odds with pneumonia and myocardial infarction. CKD was associated with poor outcomes in all stroke types. CKD should be considered as part of stroke prognosis as well as identifying at risk patient population for inhospital complications.

show abstract

Renal Function Predicts Outcomes in Patients with Ischaemic Stroke and Haemorrhagic Stroke

Cited by 27 publications

References 27 publications

High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction

High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction

Clinical and demographic features of patients with stroke and atrial fibrillation

Association of chronic kidney disease with outcomes in acute stroke

Contact Info

Product

Resources

About