Renal function 9 to 17 years after childhood lead poisoning

Moel, Donald I.; Sachs, Henrietta K.; Cohn, Richard A.; Drayton, Mary Ann

doi:10.1016/s0022-3476(85)80344-9

Cited by 13 publications

(4 citation statements)

References 10 publications

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“…A case-control study from the United States found no difference in creatinine clearance in children with lead poisoning (exposure levels 100–471 μg/dl) compared to sibling controls (Moel et al, 1985). A cross-sectional study of 196 children in Morocco found no significant correlations between blood lead and urine RBP and albumin levels (Laamech et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Environmental exposures and pediatric kidney function and disease: A systematic review

Zheng

Sanders

Saland

et al. 2017

Environmental Research

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Background Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. Methods We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. Results We found 50 studies that met the search criteria and were included in this systematic review. Environmental exposures reviewed herein included lead, cadmium, mercury, arsenic, fluoride, aflatoxin, melamine, environmental tobacco, bisphenol A, dental procedures, phthalates, ferfluorooctanoic acid, triclosan, and thallium/uranium. Most studies assessed environmental chemical exposure via biomarkers but four studies assessed exposure via proximity to emission source. There was mixed evidence of association between metal exposures, and other non-metal environmental exposures and pediatric kidney disease and other kidney disease biomarkers. The evaluation of causality is hampered by the small numbers of studies for each type of environmental exposure, as well as lack of study quality and limited prospective evidence. Conclusion There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes.

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Section: Resultsmentioning

confidence: 99%

Environmental exposures and pediatric kidney function and disease: A systematic review

Zheng

Sanders

Saland

et al. 2017

Environmental Research

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“…Chronic poisoning with lead (blood lead levels > 60 µg/dL) has been associated with nephropathy in children and adults (Ekong et al, 2006), and was characterized by tubulointerstitial fibrosis, tubular atrophy, glomerular sclerosis, and reduced eGFR (Morgan et al, 1966;Loghman-Adham, 1997). Childhood lead poisoning can also promote hypertension (Moel et al, 1985;Hu, 1991;Fadrowski et al, 2010), prolong partial Fanconi syndrome (Loghman-Adham, 1998), and lead to abnormal renal function (Moel and Sachs, 1992;Filler et al, 2012;Fadrowski et al, 2013). In a prospective Yugoslavian birth-cohort study, high blood pressure and proteinuria were observed in offspring born to mothers living near lead-contaminated environment (Factor-Litvak et al, 1999).…”

Section: Prenatal Exposure To Edcs and Chronic Kidney Diseasementioning

confidence: 99%

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

et al. 2021

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Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime. Exposure to endocrine disrupting chemicals (EDCs) during fetal development can affect the hormone system homeostasis, resulting in a broad spectrum of adverse health outcomes. In the present review, we have described the effect of prenatal EDCs exposure on cardio-metabolic-renal health, using the available epidemiological and experimental evidence. We also discuss the potential mechanisms of their action, which include epigenetic changes, hormonal imprinting, loss of energy homeostasis, and metabolic perturbations. The effect of prenatal EDCs exposure on cardio-metabolic-renal health, which is a complex condition of an altered biological landscape, can be further examined in the case of other environmental stressors with a similar mode of action.

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“…The kidneys of these individuals were found to be contracted and small, with histologic changes of interstitial fibrosis, hypertensive vascular changes, and “alterative glomerulitis” [47, 48], which is a term coined by Kimmelstiel and Wilson in 1936 to describe histological findings of nuclear proliferation and irregular pyknotic nuclei in the glomerular tuft adjacent to the vascular pole seen in hypertension-induced glomerulosclerosis [49]. Although subsequent studies of adults who suffered childhood lead poisoning have reported hypertension [50, 51], persistent partial Fanconi’s syndrome [52], and individual cases consistent with lead nephropathy [50], they have not demonstrated overall increased mortality or statistically significant decreased kidney function [53]. A possible explanation for this discrepancy may be that the children in the Queensland epidemic were untreated, whereas children in subsequent studies were treated with chelation therapy.…”

Section: Heavy Metal Nephrotoxicantsmentioning

confidence: 99%

Toxic environmental exposures and kidney health in children

2015

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High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.

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Renal function 9 to 17 years after childhood lead poisoning

Cited by 13 publications

References 10 publications

Environmental exposures and pediatric kidney function and disease: A systematic review

Environmental exposures and pediatric kidney function and disease: A systematic review

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

Toxic environmental exposures and kidney health in children

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