Renal Cell Carcinoma, a New Complication of Analgesic Nephropathy

CKD and the Risk of Incident Cancer

“…However, we controlled for the presence or absence of major confounders and longitudinal exposure to the most common relevant medications that may impact cancer risk, and the strong increased risk of renal cancer (and to a lesser degree, urothelial cancer) argues against missing a major confounder. Data were also unavailable for selectedover-the-counteranalgesicsandtoxinexposure.Phenacetin, an analgesic that has been off the market for more than three decades, has been closely linked to both urothelial and renal cancer, 29,30 but it is very unlikely to have been used by our cohort members in our contemporary study period. However, we recognize that recent data raise some concern about the association of renal cancer and nonaspirin, nonsteroidal anti-inflammatory drug use.…”

Seminoma Testis and Concomitant Ipsilateral Renal Cell Carcinoma

“…Moreover, if it was only chance, one might expect melanoma or hema tologic malignancies to coincide with testicular cancer because they have incidence peaks in the same age groups [25][26][27], The etiology of RCC is still unknown. So far, an asso ciation with tobacco smoking [28], analgesics [29] and a weak linkage to genetic factors [30] have been described. None of these factors applies to the patient described in this paper, nor do the etiologic factors postulated for TC apply.…”

The Evaluation of the Renal Transplant Candidates: Clinical Practice Guidelines

“…The standardized incidence ratio of renal carcinoma in the dialysis population was 9.9 (95% confidence interval 7.7-12.3) in Australia and New Zealand, 3.3 (3.1-3.6) in Europe and 3.7 (3.5-3.9) in the US (44). Patients with ESRD from analgesic nephropathy, Balkan nephropathy or Chinese-herb nephropathy are at especially high risk for urothelial malignancies (49)(50)(51). The duration of time on dialysis increases the relative risk of renal cancer for dialysis patients (44).…”