Seminoma Testis and Concomitant Ipsilateral Renal Cell Carcinoma

Dieckmann, K.‐P.; Loy, V.; Klän, R.

doi:10.1159/000281303

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…In the present study, there was a striking association of seminoma with subsequent renal cell cancer, and curiously, in group B of the present investigation, there were 2 more renal carcinomas preceding seminoma. This association was also found in the largest series of second tumors after testicular cancer [6]and in several other reports, and testicular malignancies were the majority of these seminomas [36, 44, 45, 46, 47, 48, 49, 50, 51]. Other studies, however, failed to find a significantly increased occurrence of renal tumors in cohorts of testicular cancer patients [4, 5, 35, 52].…”

Section: Discussionsupporting

confidence: 67%

Second Malignancies following Pure Seminoma

Rüther

Dieckmann²,

Bussar-Maatz

et al. 2000

Oncology

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Purpose: Second malignancies in patients with pure testicular seminoma were studied in order to look for adverse late effects of treatment and to study the significance of second malignancies during follow-up. Patients, Methods: In a multicentric investigation, 839 consecutive patients with pure testicular seminoma were observed for a median follow-up of 3.9 years. Thirty-seven patients had been excluded from the study because they already had had either a contralateral testicular germ cell tumor or another malignancy. 758 patients received radiotherapy, 76 underwent chemotherapy, 5 had surveillance only. The expected rate of second cancers was calculated according to the data of the cancer registry of Saarland, Germany. Results: Twenty-two second cancers (13 contralateral testicular tumors, 9 extratesticular malignancies) were recorded. The overall risk of having a second cancer was RR = 4.8 (95% CI 3.0–7.3). The risk of having a subsequent testicular tumor is RR = 44.8 (95% Cl 23.9–76.7). 1.1% of the patients developed a nontesticular second tumor. The risk of having a nontesticular second cancer is RR = 2.1 (95% CI 1.0–4.0). A significantly increased risk was observed for renal cell cancer as well (RR = 12.5; 95% Cl: 1.5–45.1). Increased RR without reaching statistical significance were found for rectal cancer (RR = 5.0; 95% Cl: 0.1–27.9) and non-Hodgkin lymphoma (RR = 6.7; 95% CI 0.2–37.1). None of the second cancers were directly located within the radiation field; 5 neoplasms arose at the border of the radiation field. Conclusions: This study confirmed the increased risk of having a second testicular germ cell cancer. There is also a small but definitely increased overall risk of having a nontesticular second cancer. Treatment-unrelated factors – possibly genetic predisposition – must be considered for a substantial number of these second tumors, since in the present study the follow-up was rather short and most of the second cancers were located outside of the radiation fields. In particular, the association of renal cancer with testicular cancer appears to be a more than chance occurrence. Second cancer is a real hazard following treatment of testicular cancers and should always be considered during follow-up.

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Section: Discussionsupporting

confidence: 67%

Second Malignancies following Pure Seminoma

Rüther

Dieckmann²,

Bussar-Maatz

et al. 2000

Oncology

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“…25 nontesticular malignancies occurred in a total of 23 patients (3.9%; 95% confidence intervals ± 1.6%), 3 of whom have been discussed in previous communications [30][31][32], Among the 25 NTMs, there were 16 histological ly different tumors. Bladder cancer and bronchogenic car cinoma occurred each 3 times.…”

Section: Resultsmentioning

confidence: 99%

Multiple Primary Neoplasms in Patients with Testicular Germ Cell Tumor

Dieckmann

Wegner

Krain³

1994

Oncology

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The study of multiple primary neoplasms may provide more insight into the pathogenesis of specific cancers and, secondly, it addresses the issue of treatment-related induction of second tumors. 584 consecutive patients with testicular germ cell tumors treated during 1969-1992 in Berlin were retrospectively analyzed for the prevalence of multiple primary neoplasms. 23 patients (16 pure seminoma, 7 nonseminoma) developing nontesticular malignancies in addition to testis cancer were identified (3.9%, 95 confidence intervals ± 1.6%). The mean age at the time of the testis cancer was 42.8 years, and mean age at the time of nontesticular malignancy was 50.2 years. In 4 cases, the nontesticular malignancy preceded testis cancer, in 3 patients both neoplasms occurred simultaneously, and in 16, nontesticular malignancies developed subsequently to testis cancer. In 4 patients, triple malignancies were observed. Bladder carcinoma and bronchogenic cancer with each 3 cases were the most frequent second neoplasms seen in these patients. 9 consecutive cancers developed within radiation fields, the median latency period in these cases was 12 years. None of the subsequent cancers developed after chemotherapy. It is concluded that genetic predisposition and radiation effects are the most important factors contributing to the occurrence of multiple primary neoplasms in patients with testicular germ cell cancer. The high rate of multiple primary neoplasms in these patients lends further evidence to the theory of genetic anticipation of germ cell cancer.

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“…There are 12 reports of patients having simultaneous testicular and renal malignancy [5][6][7][8][9]. Metachronous malignant neoplasms developing after treatment for testicular germ cell tumours are uncommon, but the development of a renal cell carcinoma after a previous testicular tumour is particularly rare.…”

Section: Discussionmentioning

confidence: 99%