Renal biomarker changes associated with hyaline droplet nephropathy in rats are time and potentially compound dependent

Brott, David; Bentley, Patricia; Nadella, Murali V.P.; Thurman, Dale; Fikes, Jim; Cheatham, Letitia; McGrath, Frank P.; Luo, Wei; Kinter, Lewis B.

doi:10.1016/j.tox.2012.11.003

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…For example, the compound isopropanol leads to increased expression of the gene NQO1's mRNA (Vandebriel et al, 2010). This, together with the fact that inhibition of NQO1 is linked to the amelioration of kidney diseases (Chen et al, 2011), enables a new discovery, namely the relation between isopropanol and kidney diseases (Brott et al, 2013). Using a comprehensive dataset containing thousands of such facts, this model can be employed to understand the dynamics of scientific discovery.…”

Section: Resultsmentioning

confidence: 99%

Information silos distort biomedical research

Rodriguez‐Esteban

2021

Preprint

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Information silos have been an oft-maligned feature of scientific research for introducing a bias towards knowledge that is produced within a scientist's own community. The vastness of the scientific literature has been commonly blamed for this phenomenon, despite recent improvements in information retrieval and text mining. Its actual negative impact on scientific progress, however, has never been quantified. This analysis attempts to do so by exploring its effects on biomedical discovery, particularly in the discovery of relations between diseases, genes and chemical compounds. Results indicate that the probability that two scientific facts will enable the discovery of a new fact depends on how far apart these two facts were published within the scientific landscape. In particular, the probability decreases exponentially with the citation distance. Thus, the direction of scientific progress is distorted based on the location in which each scientific fact is published, representing a path-dependent bias in which originally closely-located discoveries drive the sequence of future discoveries. To counter this bias, scientists should open the scope of their scientific work with modern computational approaches.

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Section: Resultsmentioning

confidence: 99%

Information silos distort biomedical research

Rodriguez‐Esteban

2021

Preprint

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“…Meso Scale Discovery’s multiple array technology enables the detection of urinary biomarkers in multiplex formats using electrochemiluminescence detection [23]. In this study, we used this multiplex immunoassay system to analyze a number of urinary biomarkers (albumin, Kim-1, NGAL, osteopontin, fibrinogen, α-GST, GST-Yb1, RPA-1 and clusterin) (Figure 2A–J).…”

Section: Resultsmentioning

confidence: 99%

Urinary Biomarkers Track the Progression of Nephropathy in Hypertensive and Obese Rats

et al. 2013

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Aims To determine whether urinary biomarkers of acute kidney injury can be used to monitor the progression of chronic kidney injury in a rat model of hypertension and obesity. Materials & methods A suite of novel urinary biomarkers were used to track the progression of kidney damage in SHROB and SHR-lean rats. Results Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with the severity of histopathologically determined nephropathy in both SHROB and SHR-lean rats. Conclusion Urinary biomarkers, such as albumin, fibrinogen, NAG, clusterin, RPA-1 and osteopontin, may serve as useful tools to track the progression of chronic kidney disease associated with hypertension and obesity.

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“…Moreover, excessive accumulation of hyaline droplets was correlated with renal injury. Even though the BUN and serum creatinine levels are considered as the gold standard of renal injury, accompanied by histopathological findings, certain hyaline droplet nephropathies induced by chemicals do not induce serum biochemistry changes [30].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulation of 2uglobulin is considered to be responsible for apoptosis, which stimulates cell division as a repair/regenerative response [34]. Repeated cycles of cytotoxicity and cellular replication due to the dose-dependent accumulation of hyaline droplets were thought to be associated with the renal tumorigenic response [30,37].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol

Jeong

Shin

Lee

et al. 2022

Toxics

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Chlorobutanol (CB) is used as a preservative in cosmetics and has antibacterial activity. This study investigated the single- and repeated-dose 28-day oral toxicity of a CB solvent in Sprague Dawley (SD) rats. For the single-dose oral toxicity study, a dose of 62.5, 125, or 250 mg per kg of body weight (mg/kg b.w.) of CB was given once orally via gavage. For the repeated-dose 28-day toxicity study, the high dose was set as 100 mg/kg b.w./day, and the middle, middle-low, and low doses were set to 50, 25, and 12.5 mg/kg b.w./day, respectively. Body weight was not significantly changed in the repeated-dose toxicity study. Relative liver and kidney weights were significantly increased in both sexes of the 100 mg/kg b.w./day treatment group. However, there were histopathological changes in liver and kidney for females and males, respectively. These data suggested that the approximate lethal dose (ALD) of CB was over 250 mg/kg b.w./day in the single-dose study, and the no adverse effect level (NOAEL) for CB was over 50 and 12.5 mg/kg b.w./day for female and male rats in the repeated-dose toxicity study.

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Renal biomarker changes associated with hyaline droplet nephropathy in rats are time and potentially compound dependent

Cited by 7 publications

References 31 publications

Information silos distort biomedical research

Information silos distort biomedical research

Urinary Biomarkers Track the Progression of Nephropathy in Hypertensive and Obese Rats

In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol

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