Urinary Biomarkers Track the Progression of Nephropathy in Hypertensive and Obese Rats

Zhang, Qin; Davis, Kelly J.; Hoffmann, Dana; Vaidya, Vishal S.; Brown, Ronald P.; Goering, Peter L.

doi:10.2217/bmm.13.106

Cited by 31 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These biomarkers have also recently been used to detect adverse effects of chronic exposures to renal environmental toxicants such as metals and have allowed early detection of injury [Zhou et al, 2008;Prozialeck et al, 2009;Zhang et al, 2014]. Results present in Table V for the AKI biomarkers (IL-18; KIM-1 and NGAL) suggest that we may be seeing signs of early AKI in some members of this veteran cohort.…”

Section: Urinary Low Molecular Weight Proteins: Biomarkers Of Renal Pmentioning

confidence: 84%

Biologic monitoring and surveillance results for the department of veterans affairs' depleted uranium cohort: Lessons learned from sustained exposure over two decades

McDiarmid

Gaitens

Hines

et al. 2015

American J Industrial Med

View full text Add to dashboard Cite

show abstract

Section: Urinary Low Molecular Weight Proteins: Biomarkers Of Renal Pmentioning

confidence: 84%

Biologic monitoring and surveillance results for the department of veterans affairs' depleted uranium cohort: Lessons learned from sustained exposure over two decades

McDiarmid

Gaitens

Hines

et al. 2015

American J Industrial Med

View full text Add to dashboard Cite

show abstract

“…Changes in the urinary excretion of B2M, cystatin C, osteopontin, and uromodulin have been associated with varying forms of kidney injury, 27,33,[50][51][52][53][54][55]231 but were not different between preeclampsia cases and controls. Increased urine NGAL has been associated with acute kidney injury, 51,56,57 but we found levels to be decreased in preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Complement Activation and Kidney Injury Molecule-1–Associated Proximal Tubule Injury in Severe Preeclampsia

et al. 2014

View full text Add to dashboard Cite

We enrolled 25 cases with severe preeclampsia, 25 controls with chronic hypertension, and 25 healthy controls without hypertension from a cohort of women receiving care at Brigham and Women's Hospital from March 2012 through March 2013. Institutional review board approval was obtained through the Partners Human Research Committee, and subjects gave informed consent. All procedures followed were in accordance with institutional guidelines. Methods Abstract-Kidney injury with proteinuria is a characteristic feature of preeclampsia, yet the nature of injury in specific regions of the nephron is incompletely understood. Our study aimed to use existing urinary biomarkers to describe the pattern of kidney injury and proteinuria in pregnancies affected by severe preeclampsia. We performed a case-control study of pregnant women from Brigham and Women's Hospital from 2012 to 2013. We matched cases of severe preeclampsia (n=25) 1:1 by parity and gestational age to 2 control groups with and without chronic hypertension. Urinary levels of kidney injury molecule-1 and complement components (C3a, C5a, and C5b-9) were measured by enzyme-linked immunosorbent assay, and other markers (albumin, β2 microglobulin, cystatin C, epithelial growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, and uromodulin) were measured simultaneously with a multiplex electrochemiluminescence assay. Median values between groups were compared with the Wilcoxon signed-rank test and correlations with Spearman correlation coefficient. Analysis of urinary markers revealed higher excretion of albumin and kidney injury molecule-1 and lower excretion of neutrophil gelatinase-associated lipocalin and epithelial growth factor in severe preeclampsia compared with chronic hypertension and healthy controls. Among subjects with severe preeclampsia, urinary excretion of complement activation products correlated most closely with kidney injury molecule-1, a specific marker of proximal tubule injury (C5a: r=0.60; P=0.001; and C5b-9: r=0.75; P<0.0001). Taken together, we describe a pattern of kidney injury in severe preeclampsia that is characterized by glomerular impairment and complement-mediated inflammation and injury, possibly localized to the proximal tubule in

show abstract

“…Zhang et al tracked the progression of nephropathy in hypertensive and obese SHROB rats versus control hypertensive SHR-lean rats. Their results indicate that urinary NAG was elevated at week 33 and 36 in SHROB rats only, but not in SHR-lean rats at any time point [18], indicating that NAG may be an early reliable marker for obesity-related renal injury. Goknar et al demonstrated that urinary NAG was significantly elevated in obese children compared with lean controls [11].…”

Section: N-acetyl-beta-d-glucosaminidasementioning

confidence: 98%

Early markers of obesity-related renal injury in childhood

Ding

Mak

2014

Pediatr Nephrol

View full text Add to dashboard Cite

Childhood obesity has become a global epidemic. Recent epidemiological data suggest that obesity is associated with increased risk of renal injury in children. The onset of obesity-associated renal disease is insidious and asymptomatic, so early markers will be extremely useful in its prevention and treatment. Biomarker discovery can be focused on unbiased or biased (candidate) approaches. Unbiased approaches using innovative technologies, such as proteomics and metabolomics, have uncovered candidates that are emerging as plausible biomarkers for such renal disorders as obstructive uropathy and diabetic nephropathy. Biased approaches are based on hypotheses related to glomerular or tubular injury pathophysiology in obesity. Goknar et al. (Pediatric Nephrology 2014; doi: 10.1007/s00467-014-2829 recently evaluated early urine renal injury markers, namely, microalbuminuria, N-acetyl-beta-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and kidney injury molecule (KIM)-1, in obese children. They reported that obese children had higher urinary NAG and KIM-1 levels than healthy controls. Longitudinal observation studies are needed to evaluate whether these tubular damage markers are useful as early markers of renal injury in obese children.

show abstract

Urinary Biomarkers Track the Progression of Nephropathy in Hypertensive and Obese Rats

Cited by 31 publications

References 29 publications

Biologic monitoring and surveillance results for the department of veterans affairs' depleted uranium cohort: Lessons learned from sustained exposure over two decades

Biologic monitoring and surveillance results for the department of veterans affairs' depleted uranium cohort: Lessons learned from sustained exposure over two decades

Complement Activation and Kidney Injury Molecule-1–Associated Proximal Tubule Injury in Severe Preeclampsia

Early markers of obesity-related renal injury in childhood

Contact Info

Product

Resources

About