Remodeling of white adipose tissue metabolism by physical training prevents insulin resistance

Higa, Talita Sayuri; Spinola, Acauã Vida; Fonseca‐Alaniz, Miriam Helena; Evangelista, Fabiana S.

doi:10.1016/j.lfs.2014.02.039

Cited by 40 publications

(56 citation statements)

References 61 publications

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“…The present study enhances the understanding of how chronic physical activity or physical training promotes several health benefits . The adaptations occurring in muscle and white adipose tissues justify, for example, the use of aerobic training as a nonpharmacological intervention to prevent the development of metabolic diseases . During physical exercise sessions, the enhanced sympathetic outflow disrupts lipid homeostasis to attend the increased muscle demand for substrates .…”

Section: Discussionmentioning

confidence: 71%

“…Therefore, our data suggest that aerobic training preserved or even augmented lean body mass, although we did not measure this parameter. Reductions in adipose tissue weight and/or body adiposity are commonly reported following aerobic training consisting of a treadmill run . For example, 6 weeks of training have been shown to reduce by 50% the weight of periuterine adipose tissue in female rats, whereas an 8‐week training lowered body adiposity, although it did not change the body weight of trained mice …”

Section: Discussionmentioning

confidence: 99%

“…Reductions in adipose tissue weight and/or body adiposity are commonly reported following aerobic training consisting of a treadmill run. 40,41 For example, 6 weeks of training have been shown to reduce by 50% the weight of periuterine adipose tissue in female rats, 41 whereas an 8-week training lowered body adiposity, although it did not change the body weight of trained mice. 40 The present findings revealed that training did not change the serum concentrations of triacylglycerol, NEFA, and total cholesterol.…”

Section: Discussionmentioning

confidence: 99%

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Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues

Cordeiro

Mario

Moreira

et al. 2019

J of Cellular Biochemistry

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Aerobic training induces adaptive responses in skeletal muscles and white adipose tissues, thus facilitating lipid utilization as energy substrates during a physical exercise session. However, the effects of training on cytokines levels and on transcription factors involved in lipid metabolism in muscle and different white adipose depots are still unclear; therefore, these were the aims of the present study. Nineteen adult male Wistar rats were randomly assigned to a trained group or a control, non‐trained group. The 10‐week training protocol consisted of running on a treadmill, during 1 hour per day, 5 days per week, at 75% of maximum aerobic speed. As expected, trained rats improved their aerobic performance and had augmented citrate synthase activity in the soleus, while the control rats did not. Although body weight was not different between groups, the adiposity index and white adipose depots (ie, epididymal and retroperitoneal) were reduced in trained rats. Training reduced serum concentration of insulin, but failed to change serum concentrations of glucose, triacylglycerol, total cholesterol, and nonesterified fatty acids. Training increased sterol regulatory element‐binding protein‐1c expression in the gastrocnemius and epididymal adipose tissue, and reduced peroxisome proliferator‐activated receptor γ (PPARγ) expression in most of the tissues analyzed. The expression of PPARα and carnitine palmitoyltransferase 1 increased in the gastrocnemius and mesenteric adipose tissue but reduced in epididymal adipose tissue. Triacylglycerol content and tribbles 3 expression reduced in the gastrocnemius of trained rats. Tumor necrosis factor‐α and interleukin‐6 were increased in all adipose depots evaluated. Collectively, our data indicate that the 10‐week aerobic training changed gene expression to improve muscle oxidative metabolism and facilitate lipid degradation in adipose tissues. Our data also highlight the existence of adaptive responses that are distinct between the skeletal muscle and white adipose tissue and between different adipose depots.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues

Cordeiro

Mario

Moreira

et al. 2019

J of Cellular Biochemistry

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“…); in WAT, it enhances lipolysis and the level of phosphorylated HSL (Higa et al. ; Ogasawara et al. ).…”

Section: Discussionmentioning

confidence: 99%

Expression of genes involved in carbohydrate-lipid metabolism in muscle and fat tissues in the initial stage of adult-age obesity in fed and fasted mice

et al. 2017

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C57Bl mice exhibit impaired glucose metabolism by the late adult age under standard living conditions. The aim of this study was to evaluate white adipose tissue (WAT), brown adipose tissue (BAT), and skeletal muscle expression of genes involved in carbohydrate‐lipid metabolism at postpubertal stages preceding the late adult age in C57Bl mice. Muscle mRNA levels of uncoupling protein 3 (Ucp3) and carnitine palmitoyltransferase 1 (Cpt1) (indicators of FFA oxidation), WAT mRNA levels of hormone‐sensitive lipase (Lipe) and lipoprotein lipase (Lpl) (indicators of lipolysis and lipogenesis), muscle and WAT mRNA levels of the type 4 glucose transporter Slc2a4 (indicators of insulin‐dependent glucose uptake), and BAT mRNA levels of uncoupling protein 1 (Ucp1) (indicator of thermogenesis) were measured in fed and 16 h‐fasted mice in three age groups: 10‐week‐old (young), 15‐week‐old (early adult), and 30‐week‐old (late adult). Weight gain from young to early adult age was not accompanied by changes in WAT and BAT indexes and biochemical blood parameters. Weight gain from early to late adult age was accompanied by increased WAT and BAT indexes and decreased glucose tolerance. Muscle Ucp3 and Cpt1 mRNA levels and WAT Lipe and Slc2a4 mRNA levels increased from young to early adult age and then sharply decreased by the late adult age. Moreover, BAT Ucp1 mRNA level decreased in the late adult age. Fasting failed to increase muscle Cpt1 mRNA levels in late adult mice. These transcriptional changes could contribute to impaired glucose metabolism and the onset of obesity in late adult mice during normal development.

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“…Figure 1 summarizes this hypothesis. This idea is supported by another recent study in mice which demonstrated enhanced stimulation of lipolysis and insulin sensitivity following exercise training, which correlated with increased FFA oxidation and lower lipid storage in WAT (13). That study examined male diet-induced obese C57BL/6 mice and found that exercise attenuated gains in adiposity, prevented insulin resistance, reduced expression of glucose 6-phosphate dehydrogenase, an enzyme involved in fatty acid synthesis, and increased citrate synthase activity, a marker of mitochondrial function, in WAT (13).…”

Section: Introductionmentioning

confidence: 62%

Exercise and Estrogen Make Fat Cells “Fit”

Vieira‐Potter

Zidon

Padilla

2015

Exercise and Sport Sciences Reviews

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Adipose tissue inflammation links obesity and metabolic disease. Both exercise and estrogen improve metabolic health, enhance mitochondrial function, and have anti-inflammatory effects. We hypothesize that there is an inverse relationship between mitochondrial function and inflammation in adipose tissue and that exercise acts as an estrogen “mimetic”. Explicitly, exercise may improve adipose tissue “immunometabolism” by improving mitochondrial function and reducing inflammation. Summary Exercise improves adipose tissue metabolic health by reducing inflammation and improving mitochondrial function.

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Remodeling of white adipose tissue metabolism by physical training prevents insulin resistance

Cited by 40 publications

References 61 publications

Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues

Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues

Expression of genes involved in carbohydrate-lipid metabolism in muscle and fat tissues in the initial stage of adult-age obesity in fed and fasted mice

Exercise and Estrogen Make Fat Cells “Fit”

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