Remineralizing potential of CPP-ACP in white spot lesions – A systematic review

Indrapriyadharshini, K; Kumar, Pratyush; Sharma, Khushbu; Iyer, Kiran

doi:10.4103/ijdr.ijdr_364_17

Cited by 38 publications

(38 citation statements)

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“…21 The use of CPP-ACP in the current study was based upon the positive results demonstrated in previous studies that investigated the effect of different CPP-ACP formulations on the prevention of WSLs, 23,24 with no significant difference compared to fluoride compounds. 7,8 . Use of CPP-ACP resulted in signifi- cantly less lesion depth (48.7%) compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

“…6 When CPP-ACP was compared with fluoride compounds, which are the gold standard for prevention of demineralization, a systematic review in 2018 pointed out a high level evidence of remineralizing potential of CPP-ACP on WSLs compared with fluoridated toothpaste and fluoride varnish without a statistically significant difference. 7 A systematic review in 2019 that reviewed effectiveness of CPP-ACP products in prevention of WSLs in orthodontic patients, showed that, although CPP-ACP-containing products did not differ from other fluoride products, they were able to reduce WSLs and neutralize the pH around orthodontic brackets. 8 Recently, it was shown that treatment with lasers reduced subsurface demineralization.…”

Section: Introductionmentioning

confidence: 99%

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Combined effect of Er,Cr:YSGG laser and casein phosphopeptide amorphous calcium phosphate on the prevention of enamel demineralization:

Adel¹,

Marzouk²,

El-Harouni³

2020

The Angle Orthodontist

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Objectives To compare the effect of use of laser, casein phosphopeptide–amorphous calcium phosphate (CPP–ACP), and their combination on prevention of enamel demineralization using polarized light microscopy to assess lesion depth. Materials and Methods Eighty premolars were randomly allocated to four equal groups (n = 20): Group I: Control group, no preventive measures. Group II: CPP–ACP. Group III: Er,Cr:YSGG laser. Group IV: Er,Cr:YSGG laser followed by CPP–ACP. Specimens were subjected to thermocycling and brushing protocols equivalent to 1 year intraorally. Then, all teeth were subjected to acid challenge. Teeth were then sectioned longitudinally and examined under a polarized light microscope and lesion depth was measured. Results Group IV resulted in the least lesion depth with a significant difference between it and all other groups. CPP–ACP alone and laser alone also showed a significant difference in white spot lesion (WSL) depth compared to the control group; however, no significant difference was found between them. Conclusions The combined use of laser and CPP–ACP showed the best prevention against WSL development. The use of CPP–ACP or laser alone also resulted in a significant reduction in lesion depth but was significantly less than their combined use, with no significant difference between them.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combined effect of Er,Cr:YSGG laser and casein phosphopeptide amorphous calcium phosphate on the prevention of enamel demineralization:

Adel¹,

Marzouk²,

El-Harouni³

2020

The Angle Orthodontist

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“…Casein phosphopeptide amorphous calcium phosphate is a milk based agent in which CPP forms nanoclusters with ACP, CPP−ACP can stabilize calcium and phosphate ions in the solution. Thus providing a pool of calcium and phosphate ions which can maintain them in supersaturation level, also it has buffering action to plaque pH (3,4) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Casein Phosphopeptide–Amorphous Calcium Phosphate Mousse versus Natural Raw Fresh Milk on Enamel Surface Roughness After a pH Challenge

Al-Ani¹,

Al-Naimi²

2020

RDENTJ

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Aims: The aim of this study is to evaluate the effect of CPP−ACP, raw, fresh buffalo milk and cow milk on surface roughness of artificial initial caries lesions. Materials and Methods: 100 sound maxillary first premolar extracted for the purpose of orthodontic treatment had been collected and randomly divided into four groups, in all groups the teeth subjected to pH cycle procedure then treated with: Group1: n(25) deionized water, group2: n(25) CPP−ACP tooth mousse, group3: n(25) raw cow milk, group4: n(25) raw buffalo milk. Enamel surface was assessed by a profilometer device at a baseline and after demineralization and after remineralization. Results: In all groups, there was a high statistically significant increase in surface roughness after demineralization. And there was a high statistically significant decrease in surface roughness in all groups except deionized water after remineralization, the highest remineralization effect was found in CPP−ACP tooth mousse group followed by buffalo milk and then cow milk.Conclusions: Within the limits of the current study, it was concluded that CPP−ACP tooth mousse, raw fresh buffalo milk and cow milk were effective remineralizing agents which was reflected by decreasing surface roughness of artificial initial caries lesion, but with different potentials, CPP−ACP tooth mousse was the best followed by fresh raw buffalo milk which showed superior results in reducing surface roughness in comparison with fresh raw cow milk.

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“…In Table (1), the results showed there were no significant difference at baseline and demineralization between and within groups due to the use the same protocol of demineralization for all groups, while in demineralization there was a high significant difference between and (21,22) .…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the Effect of Casein Phosphopeptide–Amorphous Calcium Phosphate Mousse versus Natural Raw Fresh Milk on Enamel Hardness After a pH Challenge

Al-Ani¹,

Al-Naimi²

2021

RDENTJ

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Aims:The aim of this study was to evaluate the effect of CPP−ACP, raw fresh buffalo milk and cow milk on the microhardness of artificial initial caries lesions. Materials and Methods: 100 sound maxillary first premolars were collected and randomly divided into four groups, the teeth in all groups were subjected to pH cycling procedure then treated with: Group1: n (25) deionized water, group2: n (25) CPP−ACP tooth mousse, group3: n (25) fresh raw cow milk, group4: n (25) fresh raw buffalo milk. Enamel surface was assessed by Vickers microhardness test device at a baseline and after demineralization and after remineralization. Results: In all groups, there were high statistically significant reduction of surface microhardness after demineralization. There was high statistically significant increase in surface microhardness in all groups except deionized water after remineralization, the highest remineralization effect was found in CPP−ACP tooth mousse group followed by the milk groups that showed encouraging results with fresh raw buffalo milk having superior results then fresh raw cow milk. Conclusions: CPP−ACP tooth mousse, raw fresh buffalo milk and cow milk were effective remineralizing agents which were reflected by increasing the surface microhardness of artificial initial caries lesion, but with different abilities, CPP−ACP tooth mousse was the best followed by buffalo milk then cow milk.

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Remineralizing potential of CPP-ACP in white spot lesions – A systematic review

Cited by 38 publications

References 1 publication

Combined effect of Er,Cr:YSGG laser and casein phosphopeptide amorphous calcium phosphate on the prevention of enamel demineralization:

Combined effect of Er,Cr:YSGG laser and casein phosphopeptide amorphous calcium phosphate on the prevention of enamel demineralization:

Evaluation of the Effect of Casein Phosphopeptide–Amorphous Calcium Phosphate Mousse versus Natural Raw Fresh Milk on Enamel Surface Roughness After a pH Challenge

Evaluation of the Effect of Casein Phosphopeptide–Amorphous Calcium Phosphate Mousse versus Natural Raw Fresh Milk on Enamel Hardness After a pH Challenge

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