Remineralization efficiency of bioactive glass on artificially induced carious lesion an in-vitro study

Narayana, Sai Sathya; Deepa, Vinoth Kumar; Ahamed, Shafie; Sathish, Emmanuel Solomon; Meyappan, Ramanathan; Kumar, K S Satheesh

doi:10.4103/0970-4388.127047

Cited by 49 publications

(13 citation statements)

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“…Biomaterials are natural or synthetic materials used in biological systems to reconstruct or replace tissues, organs or bodily functions thus improving the quality of life of patients. These materials are often used in dentistry due to their ability to interact with dental tissues, inducing the remineralization process (29,31) .…”

Section: Discussionmentioning

confidence: 99%

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The effect of different biomimetic materials as a remineralization protocol on microhardness and ultramorphology of bleached enamel

Hafez

Moussa

2018

Egyptian Dental Journal

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Aim: To compare the effect of Nano-HA and Nano-BG as remineralizing protocol on the microhardness and structural morphology of bleached enamel. Materials and methods: Two different biomimetic materials were used; Nano-bioactive glass powder and Nanohyroxyapatite powder. Five extracted sound human central incisors were selected. The labial of each tooth was divided longitudinal into two equal halves. The mesial half was assigned for BG group and the distal half was assigned for HA group. A total number of 20 Specimens were randomly divided into 4 groups (5specimens each). Group1 represent sound unbleached enamel, group2 represent bleaching enamel surface, and group3 represents remineralization by BG and group4 represents remineralization by HA. The specimens in group2 were bleached using 40% Hydrogen Peroxide following the manufacturers' instructions. For Nano-BG group: a mixture of bioactive glass 45S5 powder with particle size (25-120 um) with poly-acrylic acid powder was done (PAA-BAG). Then, one milliliter of the artificial saliva was added then was applied on the bleached enamel surface followed by rinsing for one minute.For Nano-HA group: HA mixed with distilled water then was applied to bleached enamel surface followed by rinsing. All specimens were subjected to de and remineralization cycles. Surface Micro-hardness of the specimens (before bleaching after bleaching and after remineralization protocol) was determined and the mean microhardness values of the specimens were calculated, tabulated and statistically analyzed using one way analysis of variance (ANOVA) and Tukey post hoc tests were used to study the significance. The surface morphology of two representative sample of each tested group were examined using scanning electron microscope attached with energy dispersive X-ray analyzer. Results: Microhardness results revealed that the greatest mean value was recorded in unbleached enamel, followed by remineralized enamel with Nano-BG, then remineralized enamel with Nano-HA, with the least value in bleached enamel. ANOVA test revealed that the difference was extremely statistically significant (p<0.0001). Tukey's post hoc test revealed no significant difference between unbleached enamel and remineralized enamel with Nano-BG. Moreover, there was no significant remineralized enamel with Nano-HA and remineralized enamel with Nano-BG. This was associated with some morphological changes in the enamel surfaces between different tested groups.

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Section: Discussionmentioning

confidence: 99%

“…In an aqueous environment, this material undergoes a series of reactions, resulting in the formation of a surface layer made of hydroxy-apatite and/ or hydroxycarbonate apatite. (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) However, the remineralization potential of bioactive glass has so far not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

The effect of different biomimetic materials as a remineralization protocol on microhardness and ultramorphology of bleached enamel

Hafez

Moussa

2018

Egyptian Dental Journal

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“…This mechanism is found to be lacking in CPP-ACP and fluoride pastes. 2 Another factor proving better remineralizing potential of these recent remineralizing agents could be the ionic reactions and resultant surface modifications beneficially interacting with collagen, allowing for strong bonding between collagen and the surfaces of these materials. This allows calcium sodium phosphosilicate particles to attach and remain on the dentin surface for a longer period of time and act as a reservoir for the continued long-term release of calcium and phosphate ions into the local environment as stated by Orefice et al 11 …”

Section: Discussionmentioning

confidence: 99%

“…This compound in an aqueous environment releases bioactive calcium, sodium, and phosphate ions contributing to the remineralization process. 2 …”

Section: Introductionmentioning

confidence: 99%

Effect of Casein Phosphopeptide–amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: Anin vitroStudy

Chaudhary

Tripathi

Yadav

et al. 2017

International Journal of Clinical Pediatric Dentistry

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Aim To compare new remineralizing agents calcium sodium phosphosilicate paste and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste with that of fluoridated toothpaste in remineralization of early carious lesions using scanning electron microscopy and energy-dispersive X-ray (SEM-EDX) analysis.Materials and methods Sixty sound extracted premolars were collected and placed in demineralizing solution for 4 days to produce artificial carious lesions. All specimens were evaluated for any loss of mineral content using SEM-EDX analysis. Samples were randomly assigned to three groups: Group I: Fluoridated toothpaste (control), group II: CPP-ACP paste, and group III: Calcium sodium phosphosilicate paste. Specimens were then treated with above-mentioned remineralizing agents and again measured for mineral content using SEM-EDX analysis.Results Group III (calcium sodium phosphosilicate paste) showed highest significant difference followed in descending order by group II (CPP-ACP paste) and group I (fluoridated toothpaste).Conclusion Calcium sodium phosphosilicate paste showed maximum remineralizing potential compared with CPP-ACP and fluoridated toothpastes.How to cite this article Chaudhary I, Tripathi AM, Yadav G, Saha S. Effect of Casein Phosphopeptide-amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: An in vitro Study. Int J Clin Pediatr Dent 2017;10(3):261-266.

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“…Outermost covering of tooth is made up of enamel, which is highly vulnerable to destruction. Once destruction occurs in enamel, the process cannot be reversed due to incapacity of ameloblasts [1].…”

Section: Introductionmentioning

confidence: 99%

An in Vitro Evaluation of Remineralizing Capacity of Self-Assembling Peptide (SAP) P11-4 and Casein Phosphopeptides-Amorphous Calcium Phosphate (CPP-ACP) on Artificial Enamel

Babaji¹,

Melkundi²,

Bhagwat³

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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Objective: To determine and compare the remineralizing capacity of self-assembling peptide (SAP) P11-4 and casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) on enamel. Material and Methods: Enamel samples were divided into 2 groups. Group I was treated with Self-assembling peptide (SAP) P11-4 and group II with casein phosphopeptides-amorphous calcium phosphate (CPP-ACP). In both groups, remineralizing capacity was assessed at baseline, 2 weeks, 6 weeks and 12 weeks. Student's t-test and ANOVA were applied, with the significance level set at 5%. Results: The mean calcium weight % was evaluated at baseline, 2 weeks, 6 weeks and 12 weeks. In Group I, there was increase in mean value (62.12 ± 1.24) from baseline to 12 weeks (67.36 ± 2.14). However, there was decrease in phosphate weight % from 37.16 ± 2.52 at baseline to 35.72 ± 2.11 at 12 weeks. In Group II, mean calcium weight % was 64.18 ± 1.52 at baseline, which ultimately increased to 66.01 ± 2.03 at 12 weeks. Phosphate weight % showed reduction from 37.34 ± 2.23 at baseline to 35.04 ± 2.02 at 12 weeks. Ca/P ratio showed significant improvement. There was significant difference in Ca/P ratio at 2 weeks, 6 weeks and 12 weeks in both groups (p<0.05). Conclusion: Self-assembling peptide (SAP) P11-4 found to be more effective and efficient as compared to casein phosphopeptides-amorphous calcium phosphate (CPP-ACP).

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Remineralization efficiency of bioactive glass on artificially induced carious lesion an in-vitro study

Abstract: To focus on the importance of minimal invasive treatment on incipient carious lesion by remineralization.

Cited by 49 publications

References 1 publication

The effect of different biomimetic materials as a remineralization protocol on microhardness and ultramorphology of bleached enamel

The effect of different biomimetic materials as a remineralization protocol on microhardness and ultramorphology of bleached enamel

Effect of Casein Phosphopeptide–amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: Anin vitroStudy

An in Vitro Evaluation of Remineralizing Capacity of Self-Assembling Peptide (SAP) P11-4 and Casein Phosphopeptides-Amorphous Calcium Phosphate (CPP-ACP) on Artificial Enamel

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