Effect of Casein Phosphopeptide–amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: An<i>in vitro</i>Study

Chaudhary, Iqra Ishtiaq; Tripathi, Arvind; Yadav, Gunjan; Saha, Sonali

doi:10.5005/jp-journals-10005-1447

Cited by 11 publications

(8 citation statements)

References 89 publications

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“…The remineralizing agent contained 1.5 mM CaCl 2 , 0.9 mM NaH 2 PO 4 , and 0.15 M KCl, and the pH is adjusted to 7.0. The artificial saliva contained 0.650 g/L KCl, 0.058 g/L MgCl 2 , 0.165 g/L CaCl 2 , 0.804 g/L K 2 HPO 4 , 0.365 g/L KH 2 PO 4 , 2 g/L C 6 H 5 COONa, 7.80 g/L C 8 H 15 NaO 8 , and the pH is adjusted to 7.0 [ 30 ]. The solutions were freshly prepared for each cycle.…”

Section: Methodsmentioning

confidence: 99%

Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions

Juntavee

Hirunmoon

2021

International Journal of Dentistry

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Introduction. Nanohydroxyapatite (nano-HA) has been utilized as an alternative agent for dental enamel remineralization. This study compared remineralization potential of nano-HA toothpaste (NHT), functionalized tricalcium phosphate toothpaste (TCPT), and fluoride toothpaste (FT) on carious lesions. Materials and Methods. Sixty extracted human premolars were prepared for artificial carious lesions with synthetic polymer gel. Samples were divided into four groups according to testing agents: NHT, TCPT, FT, and one group with no treatment (NT). Each group was subjected to pH-cycling with the application of toothpaste in slurry form twice a day (2-min each) for 10 days. Surface microhardness was measured before demineralization, after demineralization, and after pH-cycling. Hardness at different periods, percentage of hardness recovery (% HR), and percentage of remineralization potential (%RP) were determined and statistically analyzed with ANOVA and Tukey comparisons (α = 0.05). Polarized light microscopy (PLM) was utilized to assess lesion depth. Results. Significant remineralization of carious lesions was observed among different toothpastes compared to NT ( p < 0.05 ). No significant difference in remineralization potential was found among NHT, TCPT, and FT ( p > 0.05 ). No significant difference in % HR and % RP was seen among NHT, TCPT, and FT ( p > 0.05 ). PLM indicated a greater decrease in carious depth upon using NHT compared to TCPT and FT, with minimal increase in depth for NT. Conclusions. NHT has comparable capability to TCPT and FT in hardness recovery. However, decrease in carious depth was evidenced with PLM for NHT more than TCPT and FT. Thus, NHT was suggested as a potential remineralization product for treating initial carious lesions. Clinical Significance. The study showed that NHT had the potential to remineralize artificial carious lesion. It was confirmed in potential in the lesion depth reduction and forming a new enamel layer. NHT showed its capability as an alternative for dental caries therapeutic.

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Section: Methodsmentioning

confidence: 99%

Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions

Juntavee

Hirunmoon

2021

International Journal of Dentistry

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“…2 Diante disso, diversas formulações de cremes dentais vêm sendo desenvolvidas com o objetivo reconstituir os minerais perdidos do esmalte dentário, tais como à base de caseína fosfato de cálcio amorfo (CPP-ACP); 2,11-14 fluoreto de sódio em diferentes concentrações; 8,11,15-19 fluoreto de estanho; 16,17 nanohidroxiapatita (nanoHAp); 18,20 zinco-hidróxiapatita (Zn-HAp); 15,17,21 tetrafluoreto de titânio; 16 silicato de cálcio combinado com fluoreto de fosfato ou fosfato de sódio; 2,5,8,9,12,22-24 fosfato de cálcio; 25 Outros estudos também demonstraram que cremes dentais com estes compostos em sua composição química são capazes de promover a remineralização do esmalte e da dentina, 8,9,5,2 aumentar a relação cálcio/ fosfato no esmalte dentário e precipitar silicato de cálcio na superfície do esmalte. 12,23,24 O modo de ação destas formulações inclui a deposição de partículas de silicato 24 No entanto, o estudo de Ionta et al 28 demonstra que esse tipo de dentifrício apresentou uma ação protetora limitada contra a erosão, evitando a perda de esmalte em aproximadamente 18% após os desafios erosivos impostos e não se diferindo de outros produtos utilizados no estudo.…”

Section: Discussionunclassified

Avaliação da microdureza superficial do esmalte dentário após o uso de substâncias remineralizadoras

Gonçalves

Arruda

Americano

et al. 2021

hu rev

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Introdução: A erosão dentária consiste na perda progressiva de tecido duro de um dente por processos químicos que não envolvem ação bacteriana. Objetivo: Avaliar, através da microdureza superficial, a remineralização do esmalte dentário após o tratamento com diferentes agentes remineralizadores. Material e Métodos: Foram confeccionados 25 blocos de esmalte dentário a partir de incisivos humanos. Os corpos de prova foram divididos aleatoriamente em cinco grupos (n=5), de acordo com o tratamento remineralizador empregado. No grupo 1 (G1), controle positivo, os corpos de prova não desmineralizados foram mantidos em água deionizada. No grupo 2 (G2), controle negativo, após desmineralização com ácido fosfórico a 37% por 5 minutos, os corpos de prova foram mantidos em água deionizada. Nos grupos 3 a 5, após desmineralização com ácido fosfórico a 37%, foram aplicados, respectivamente, gel de fluoreto de sódio a 2% (G3), creme dental à base de silicato de cálcio e fosfato de sódio (G4) e creme dental à base de fluoreto de sódio e nitrato de potássio a 5% (G5). Todos os corpos de prova foram submetidos ao teste de microdureza superficial Knoop. Os dados obtidos foram tabulados e submetidos à análise de variância (ANOVA) e teste de Tukey (significância de 5%). Resultados: Os grupos G2 (150,39±26,32), G3 (184,66±9,05) e G5 (279,26±20,77) apresentaram diferenças significativas quando comparados ao grupo controle positivo G1 (331,93±13,82) (p<0,01). Em relação ao grupo controle negativo G2 (150,39±26,32), diferenças significativas foram encontradas quando comparados aos grupos G1 (331,93±13,82), G4 (365,99±18,97) e G5 (279,26±20,77) (p<0,01). Conclusão: Pode-se observar a eficácia de cremes dentais a base de silicato de cálcio e fosfato de sódio no potencial remineralizador do esmalte dentário.

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“…Shaik et al, Chaudhary et al, and Sriamporn et al also used SEM-EDX in their in vitro studies. 27 28 29 …”

Section: Discussionmentioning

confidence: 99%

Comparison of the Remineralizing Effect of Brushing with Aloe vera versus Fluoride Toothpaste

2020

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Objectives The aim of the present in vitro study is to compare the remineralization brushing effect of three toothpastes and Aloe vera (AV) gel. Materials and Methods Forty sound extracted teeth were placed in a demineralizing solution for 4 days and randomly assigned to four groups: group A: 1,450-ppm fluoride toothpaste; group B: AV nonfluoridated toothpaste; group C: AV 1,000-ppm fluoridated toothpaste; and group D: AV gel. A 3-minute pH cycling was performed twice a day for each group for 12 days. Specimens were analyzed before and after by scanning electron microscope—energy dispersive X-ray. Statistical analysis The outcomes were analyzed by Kolmogorov–Smirnov’s tests, repeated-measures analyses of variance followed by univariate analyses, and Bonferroni’s multiple comparisons tests to compare the calcium-to-phosphorus (Ca:P) ratio within time among toothpaste groups. Results Following remineralization, the Ca:P ratio increased in all groups. The difference of the Ca:P ratio was not significant between groups C, D, and A. The mean ratio was significantly lower in group B (p-value = 0.026). Conclusions The AV gel demonstrated a remineralization capacity equal to that of the 1,450-ppm fluoride toothpaste. In contrast, fluoride-free AV toothpaste showed a lower remineralization efficiency. Further studies are required to understand its mechanism.

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Effect of Casein Phosphopeptide–amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: Anin vitroStudy

Cited by 11 publications

References 89 publications

Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions

Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions

Avaliação da microdureza superficial do esmalte dentário após o uso de substâncias remineralizadoras

Comparison of the Remineralizing Effect of Brushing with Aloe vera versus Fluoride Toothpaste

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