Relocation of specific visual functions following damage of mature posterior parietal cortex

Lomber, Stephen G.; Yi, Steven; Woller, Erin M

doi:10.1016/s0079-6123(06)57010-4

Cited by 4 publications

(5 citation statements)

References 77 publications

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“…Recovery from the deficits in correct responding due to unilateral rTRN lesions occurred in less than 2 weeks after the infusion of ibotenic acid or 7–10 days of postoperative testing. This time frame is consistent with recovery of function following ibotenic acid lesions that impaired performance on motion perception (Newsome & Paré, 1988) and visual orienting (Lomber et al, 2006). One possible explanation is that the length of preoperative training in the present study may have been sufficient to produce habitual responding.…”

Section: Discussionsupporting

confidence: 73%

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Action selection is impaired by unilateral lesions in the rostral thalamic reticular nucleus.

Weese¹

2022

Behavioral Neuroscience

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The rostral thalamic reticular nucleus (rTRN) exerts the same inhibitory control of thalamocortical transmission from the motor nuclei as the caudal sectors have over sensory nuclei. It is well established that the caudal sectors are involved in selective attention. This suggests an analogous role for rTRN in the selection of situationally appropriate behavior. Rats were trained to make an observing response followed by the illumination one of two centrally located light emitting diodes (LEDs) signaling the location of the correct nose poke to the left or right. Unilateral injections of ibotenic acid or saline were aimed at the rTRN. Postoperatively, the proportion of incorrect responses made into the hole contralateral to the lesion increased, and there was a concomitant decline in the number of correct responses directed ipsilateral to the lesion when compared with the rats with sham surgeries. Basic sensory and motor deficits do not account for these effects because response times and uncued responses did not differ between the groups. The data suggest that the diminished inhibition of the motor nuclei on the side of the rTRN lesion weakened the ability to deselect the incorrect contralateral response. We propose that the sensory and motor sectors of the TRN are functionally similar and the rTRN increases the contrast between a selected and nonselected actions.

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Section: Discussionsupporting

confidence: 73%

“…Late Errors as a Function of the Side Relative to the Lesion or Sham Surgery and Testing Period (Newsome & Paré, 1988) and visual orienting (Lomber et al, 2006). One possible explanation is that the length of preoperative training in the present study may have been sufficient to produce habitual responding.…”

Section: Figurementioning

confidence: 69%

Action selection is impaired by unilateral lesions in the rostral thalamic reticular nucleus.

Weese¹

2022

Behavioral Neuroscience

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“…In the current study, we aimed at maximizing our chances of driving significant recovery by accruing 70 sessions of excitatory rTMS on a well‐determined perilesional area shown to adopt lost visuospatial function after parietal injuries in felines (Lomber et al ., ). Our rTMS regime generated significant improvements in visuospatial orienting deficits in approximately half of our subjects, while the other half experienced maladaptive effects for the detection of static or motion stimuli displayed mainly in the ipsilesional visual hemispace.…”

Section: Discussionmentioning

confidence: 97%

“…Visuospatial responses to motion were tested at phototopic ambient light levels (43 cd/m 2 ). The Static task required animals to detect and orient to the illumination of high‐contrast static light emitting diodes (LEDs; 3 mm diameter) as described in previous studies (Lomber et al ., ; Schweid et al ., ; Valero‐Cabré et al ., ). The Moving 2 task was a motion version of the Static paradigm, in which the stimulus was a moving laser (3 mm diameter) light spot rather than a static LED.…”

Section: Methodsmentioning

confidence: 99%

“…Animals were then treated for 3.5 months with a daily regime of high-frequency real or sham rTMS over an anatomically related perilesional site known as the anterior middle suprasylvian area (aMS), previously found to adopt lost function after pMS damage ( Fig. 1; also Lomber et al, 2006). Subjects were evaluated at regular intervals and assessed in terms of hemispace and eccentricity-specific recovery.…”

Section: Introductionmentioning

confidence: 99%

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Benefit of multiple sessions of perilesional repetitive transcranial magnetic stimulation for an effective rehabilitation of visuospatial function

Afifi

Rushmore

Valero‐Cabré

2012

Eur J of Neuroscience

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Non-invasive neurostimulation techniques have been used alone or in conjunction with rehabilitation therapy to treat the neurological sequelae of brain damage with rather variable therapeutic outcomes. One potential factor limiting a consistent success for such techniques may be the few sessions carried out in patients, despite reports that their accrual may play a key role in alleviating neurological deficits long-term. In this study, we tested the effects of seventy consecutive sessions of perilesional high frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) in the treatment of chronic neglect deficits in a well-established feline model of visuo-spatial neglect. Under identical rTMS parameters and visuo-spatial testing regimes, half of the subjects improved in visuo-spatial orienting performance. The other half experienced either none or extremely moderate ameliorations in the neglected hemispace and displayed transient patterns of maladaptive visuo-spatial behavior. Detailed analyses suggest that lesion location and extent did not account for the behavioral differences observed between these two groups of animals. We conclude that multi-session perilesional rTMS regimes have the potential to induce functional ameliorations following focal chronic brain injury, and that behavioral performance prior to the onset of the rTMS treatment is the factor that best predicts positive outcomes for non-invasive neurostimulation treatments in visuo-spatial neglect.

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Evolved Mechanisms of High-Level Visual Perception in Primates

Leopold

Mitchell

Freiwald

2017

Evolution of Nervous Systems

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Relocation of specific visual functions following damage of mature posterior parietal cortex

Cited by 4 publications

References 77 publications

Action selection is impaired by unilateral lesions in the rostral thalamic reticular nucleus.

Action selection is impaired by unilateral lesions in the rostral thalamic reticular nucleus.

Benefit of multiple sessions of perilesional repetitive transcranial magnetic stimulation for an effective rehabilitation of visuospatial function

Evolved Mechanisms of High-Level Visual Perception in Primates

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