Reliability on animal models

Permuy, María; López-Peña, Mónica; González-Cantalapiedr, A.; Guzon, Fernando M. Muñoz

doi:10.1016/b978-0-08-102807-0.00013-2

Cited by 3 publications

(4 citation statements)

References 58 publications

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“…As natural hormone, MEL has numerous physiological functions in different parts of the body, such as regulating the circadian rhythms [18], modulating body temperature, activating of the immune system, also an important antioxidant and an anti-inflammatory role by reducing oxidative stress: directly by scavenging reactive oxygen and nitrogen species and indirectly by stimulating antioxidant enzymes while suppressing pro-oxidant ones [19,20]. It also exhibits anti-angiogenic effects on endothelial cells [21] and plays an important role in bone formation and in the reduction of bone resorption [22].…”

Section: Resultsmentioning

confidence: 99%

Melatonin and Hyaluronic Acid in Periodontal Disease

Cristache¹,

Totu²,

Cristache³

et al. 2019

Rev. Chim.

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The aim of the present paper was to highlight the individual effects of melatonin (MEL) and hyaluronic acid (HA) on periodontal structures and repair mechanism and to investigate a possible synergic effect and if each component of the proposed mixture (MEL-HA) would maintain their specific characteristics, when using booth active principles, for a topical application. A comprehensive review of the recent literature focusing on the role of MEL and HA in periodontal therapy, as well as on the use of both active compounds and possible synergic effect, have been conducted. An experimental investigation, using the FT-IR analysis, both the individual spectra of each component and the complex matrix obtained was performed. The experimental data obtained from our study proved that no structural changes occurred at the level of the functional groups of the components. Therefore, it is expected that the obtained formulation to be highly efficient for the treatment of periodontal disease, as it would combine the specific local action of MEL and HA.

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Section: Resultsmentioning

confidence: 99%

Melatonin and Hyaluronic Acid in Periodontal Disease

Cristache¹,

Totu²,

Cristache³

et al. 2019

Rev. Chim.

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“…Given the great potential of melatonin in bone physiology, more emphasis has been placed on using melatonin in stomatology (Permuy et al, 2017). As previously mentioned, the key to the success rate of implants is osseointegration.…”

Section: Melatonin and Implantsmentioning

confidence: 99%

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Yin²,

Sun³

et al. 2022

Front. Mol. Biosci.

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As clusters of peptides or steroids capable of high-efficiency information transmission, hormones have been substantiated to coordinate metabolism, growth, development, and other physiological processes, especially in bone physiology and repair metabolism. In recent years, the application of hormones for implant osseointegration has become a research hotspot. Herein, we provide a comprehensive overview of the relevant reports on endogenous hormones and their corresponding supplementary preparations to explore the association between hormones and the prognosis of implants. We also discuss the effects and mechanisms of insulin, parathyroid hormone, melatonin, vitamin D, and growth hormone on osseointegration at the molecular and body levels to provide a foothold and guide future research on the systemic conditions that affect the implantation process and expand the relative contraindications of the implant, and the pre-and post-operative precautions. This review shows that systemic hormones can regulate the osseointegration of oral implants through endogenous or exogenous drug-delivery methods.

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“…Proanthocyanin, a potent grape seed antioxidant, has been reported to reduce inflammation and alveolar bone loss due to periodontitis by decreasing HIF-1α and MMP-8 levels and increasing osteoblast activity in diabetic rats periodontitis (Toker et al, 2018). In a study of rats with ligamentous periodontitis, melatonin treatment appeared to suppress the production of inflammatory cytokines and relieve gingival inflammation (Permuy et al, 2017;Li L. et al, 2021). The authors concluded that melatonin could reduce oxidative stress and periodontal inflammation by decreasing the levels of inflammatory cytokines and restoring antioxidant levels in the tissues (Permuy et al, 2017;Li L. et al, 2021).…”

Section: Oxidative Stress and Periodontitismentioning

confidence: 99%

“…In a study of rats with ligamentous periodontitis, melatonin treatment appeared to suppress the production of inflammatory cytokines and relieve gingival inflammation (Permuy et al, 2017;Li L. et al, 2021). The authors concluded that melatonin could reduce oxidative stress and periodontal inflammation by decreasing the levels of inflammatory cytokines and restoring antioxidant levels in the tissues (Permuy et al, 2017;Li L. et al, 2021). Results of a murine periodontitis model clearly demonstrated that polydopamine nanoparticles could remove ROS and decrease the periodontal inflammation as robust antioxidants (Li Q. et al, 2021).…”

Section: Oxidative Stress and Periodontitismentioning

confidence: 99%

Role of oxidative stress in the relationship between periodontitis and systemic diseases

et al. 2023

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Periodontitis is a common inflammatory disease. It is characterized by destruction of the supporting structures of the teeth and could lead to tooth loss and systemic inflammation. Bacteria in inflamed gingival tissue and virulence factors are capable of entering the bloodstream to induce systemic inflammatory response, thus influencing the pathological process of many diseases, such as cardiovascular diseases, diabetes, chronic kidney disease, as well as liver injury. An increasing body of evidence show the complex interplay between oxidative stress and inflammation in disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads to oxidative stress. Oxidative stress contributes to major cellular components damage, including DNA, proteins, and lipids. In this article, the focus will be on oxidative stress in periodontal disease, the relationship between periodontitis and systemic inflammation, and the impact of periodontal therapy on oxidative stress parameters.

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Reliability on animal models

Cited by 3 publications

References 58 publications

Melatonin and Hyaluronic Acid in Periodontal Disease

Melatonin and Hyaluronic Acid in Periodontal Disease

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Role of oxidative stress in the relationship between periodontitis and systemic diseases

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