Role of oxidative stress in the relationship between periodontitis and systemic diseases

Shang, Jun; Liu, Haifeng; Zheng, Youli; Zheng, Zhiming

doi:10.3389/fphys.2023.1210449

Cited by 12 publications

(2 citation statements)

References 91 publications

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“…More recently, Yoshino et al [27], using Electron Spin Resonance, demonstrated that evaluation of the salivary antioxidant activity towards O.2 might be an effective parameter for the objective assessment of PD progression. Therefore, an imbalance between oxidative stress and antioxidant capacity played a crucial role in the pathogenesis of PD [28,29], but it still needed to be explored.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Circadian Rhythm on the Antioxidant Capacity of Saliva in Periodontal Diseases

Diab,

Choufani,

Dagher

et al. 2024

Cureus

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BackgroundSaliva has a powerful antioxidant activity proposing that it might have a protective role in the oral cavity. It is yet unclear, how circadian rhythm might affect this activity. ObjectiveThe main goal of this study was to compare the antioxidant status of saliva in patients with periodontal diseases (PD) to that of healthy people on a diurnal basis. Material and methodsA total of 18 periodontal healthy individuals and 18 patients with chronic periodontitis were chosen. Samples of saliva were collected in the morning between 6:00 and 8:00 and in the evening between 6:00 and 8:00 (both stimulated and non-stimulated). The amount of glutathione (GSH), malondialdehyde (MDA), and total antioxidant status (TAS) in the salivary samples were analyzed, and its flow was also assessed. In addition, the scavenging capacity of saliva was tested in three systems generating oxygen free radicals. ResultsResults showed that GSH and TAS concentrations in the evening saliva of healthy subjects were significantly higher than those in the morning saliva, while MDA levels decreased (p<0.05). Conversely, there was no significant increase in GSH and TAS levels in the evening saliva of subjects with PD, and lipid peroxidation remained constant. On the other hand, the evening saliva of healthy subjects but not of subjects with PD was significantly more potent in scavenging free radicals in vitro than the morning saliva, especially for the superoxide (O2.-) radical (p<0.05). Moreover, scavenging activity was higher in stimulated than nonstimulated saliva. This activity was higher in evening saliva compared to the morning one and greater in healthy subjects compared to patients with PD (p<0.05). ConclusionA balance exists between oxidative stress and antioxidant mechanisms to maintain homeostasis in the oral cavity. This balance is deregulated in patients with PD as their saliva is unable to properly scavenge free radicals that might potentially increase over the day. Antioxidant supplements may be used in accordance with the circadian rhythm to minimize oxidative damage.

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Section: Discussionmentioning

confidence: 99%

The Influence of Circadian Rhythm on the Antioxidant Capacity of Saliva in Periodontal Diseases

Diab,

Choufani,

Dagher

et al. 2024

Cureus

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“…(5) The host immune response causes most periodontal tissue damage, involving leukocytes, complement, and reactive oxygen species (ROS). (10,11) Once the level of damage surpasses the cell's ability to repair, it will induce permanent cell cycle arrest and changes in secretory phenotype reminiscent of the aging response. (12) Free radicals can lead to oxidative stress by causing an imbalance between oxidants and antioxidants, possibly damaging cells.…”

Section: Introductionmentioning

confidence: 99%

Nicotine reduces cell viability and induces oxidative stress in human gingival fibroblasts

Azmi,

Hadi,

Kusuma

et al. 2024

Univ Med

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BackgroundNicotine, as the main component of cigarettes, is known to interfere with the proliferation of human gingival fibroblasts (HGFs) and can trigger oxidative stress. This study aimed to analyze the impact of nicotine on viability, expression of the antioxidant Nrf2, levels of the product of oxidative stress malondialdehyde (MDA), and the migration capacity of HGFs. MethodsAn experimental laboratory study used fibroblasts isolated from healthy human gingiva. The cells were grouped into the non-treatment control group (NTC), the solvent control (SC), and the treatment groups, exposed to nicotine at various concentrations for twenty-four hours. Cell viability was assesed using the cell counting kit-8 (CCK-8), Nrf2 expression was examined using ELISA, MDA level was measured using an MDA kit, and migration capacity was assessed using a scratch assay. Statistical analysis used one-way Anova or Kruskal-Wallis test. A p-value of <0.05 was expressed statistically significant. ResultsThe Cell viability was substantially reduced in the nicotine group compared to the untreated group, accompanied by changes in cell morphology. In contrast, Nrf2 expression increased significantly (p=0.010) in the 5 mM nicotine group compared with the control group. The MDA levels were not significantly distinct across groups (p=0.056). Cell migration was delayed significantly in the 5 mM nicotine group at 72 hours after scratching compared to the control group. ConclusionNicotine decreased HGFs viability and increased Nrf2 expression significantly in a dose-dependent manner. Nicotine at 5 mM concentration did not alter MDA levels but delayed cell migration.

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O-Linked N-Acetylglucosamine Transferase Regulates Bone Homeostasis Through Alkaline Phosphatase Pathway in Diabetic Periodontitis

Luo,

Sun

2023

Mol Biotechnol

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Role of oxidative stress in the relationship between periodontitis and systemic diseases

Cited by 12 publications

References 91 publications

The Influence of Circadian Rhythm on the Antioxidant Capacity of Saliva in Periodontal Diseases

The Influence of Circadian Rhythm on the Antioxidant Capacity of Saliva in Periodontal Diseases

Nicotine reduces cell viability and induces oxidative stress in human gingival fibroblasts

O-Linked N-Acetylglucosamine Transferase Regulates Bone Homeostasis Through Alkaline Phosphatase Pathway in Diabetic Periodontitis

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