Reliability of sample collection and laboratory testing for HPV Detection in Men

Flores, Roberto; Abalos, Andrew T.; Nielson, Carrie M.; Abrahamsen, Martha; Harris, Robin B.; Giuliano, Anna R.

doi:10.1016/j.jviromet.2007.12.010

Cited by 39 publications

(33 citation statements)

References 32 publications

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“…This method has been shown to maximize HPV detection and result in reproducible detection of genital HPV in men (37, 38). The study clinician at each site first swept 360° around the coronal sulcus and then another 360° around the glans penis and placed the swab into a collection vial containing Specimen Transport Medium (STM, Digene.…”

Section: Methodsmentioning

confidence: 99%

Smoking and Human Papillomavirus (HPV) Infection in the HPV in Men (HIM) Study

Schabath

Villa

Lazcano‐Ponce

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background The influence of smoking on the natural history of HPV infection in men is not well-understood. Smoking could influence the incidence and persistence of HPV infections by suppressing local immune function, increase cellular proliferation, up-regulate pro-inflammatory factors, or cause host DNA damage resulting in increased susceptible to infection. The purpose of this analysis is to assess prevalent HPV infections by smoking status in men, and to determine baseline risk of HPV infection associated with smoking. Methods The HPV in Men (HIM) study is a multinational prospective study of the natural history of HPV infections in men. Samples from the coronal sulcus, glans penis, shaft, and scrotum were combined for HPV DNA testing. Multivariable logistic regression was used to assess the association between smoking and any-, oncogenic-, and non-oncogenic HPV infections. Results Our analyses revealed that current smoking was associated with an increased risk of any HPV infection (OR = 1.19; 95% CI 1.01 – 1.41) and oncogenic HPV infection (OR = 1.24; 95% CI 1.05 – 1.47). However, the association between smoking and any HPV infection (OR = 1.35; 95% CI 1.05 – 1.73) and oncogenic HPV infection (OR = 1.46; 95% CI 1.11 – 1.92) was only evident among men reporting fewer lifetime sexual partners. Discussion These results suggest that current smokers with the fewest number of sexual partners are associated with an increased risk for oncogenic HPV infection. Impact The relationship between smoking and HPV infection remains understudied in men; these data sheds new light on the interplay between smoking, sexual activity, and risk of HPV infection.

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Section: Methodsmentioning

confidence: 99%

Smoking and Human Papillomavirus (HPV) Infection in the HPV in Men (HIM) Study

Schabath

Villa

Lazcano‐Ponce

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…This method has been previously shown to maximize HPV detection among men and to result in reproducible genital HPV detection in men 10, 11 . The study clinician at each site first swept 360° around the coronal sulcus and then another 360° around the glans penis and placed this swab into a collection vial containing 450µl of Sample Transport Media (STM, Digene Corp. Gaithersburg, MD).…”

Section: Methodsmentioning

confidence: 99%

Circumcision and sexual behavior: Factors independently associated with human papillomavirus detection among men in the HIM study

Giuliano

Lazcano

Villa³

et al. 2008

Intl Journal of Cancer

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116

100

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There is growing interest in understanding HPV infection and related disease among men. To date there have been numerous studies reporting HPV DNA prevalence among men from several different countries, however, few have incorporated multivariable analyses to determine factors independently associated with male HPV detection. The purpose of this study was to assess the factors independently associated with HPV detection in men ages 18–70 years residing in Brazil (n=343), Mexico (n=312), and the United States (US) (n=333). In samples combined from the coronal sulcus, glans penis, shaft, and scrotum we evaluated factors associated with any, oncogenic, and non-oncogenic HPV infections. In multivariable analyses, detection of any HPV infection was significantly associated with reported race of Asian/Pacific Islander, lifetime and recent number of sexual partners, and having sex in the past three months. Oncogenic HPV detection was independently associated with lifetime and recent number of sexual partners, and having sex in the past three months. Non-Oncogenic HPV infection was independently associated with lifetime number of sexual partners. Circumcision, assessed by clinical examination, was associated with reduced risk of HPV detection across all categories of HPV evaluated. HPV detection in men in the current study was strongly related to sexual behavior and circumcision status. Interventions such as circumcision may provide a low cost method to reduce HPV infection.

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“…The method of Weaver BA et al includes abrading the genital skin prior to sampling with a Dacron swab and collection of the exfoliated cells in standard transport medium (STM). The method of Giuliano AR et al utilizes direct sampling of the genital epithelium with a saline pre-wetted Dacron swab followed by collection in STM [11,14,15]. …”

Section: 0 Natural History Of the Hpv Infections In External Male Gmentioning

confidence: 99%

Epidemiology of Human Papillomavirus Infection in Men, Cancers other than Cervical and Benign Conditions

Giuliano¹,

Tortolero‐Luna²,

Ferrer³

et al. 2008

Vaccine

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317

230

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Human Papillomavirus (HPV) infection is commonly found in the genital tract of men and women with or without any clinical lesion. The association of HPV DNA with several different ano-genital cancers other than cervical has been reported for the vulva, vagina, anus and penis. HPV DNA has also been identified in head and neck cancers in the oral cavity, the oropharynx and the larynx in both sexes. In men, 80–85% of anal cancers and close to 50% of penile cancers are associated with HPV infection. In women, HPV DNA is prevalent in 36–40 % vulvar cancer cases and close to 90 % of vaginal cancers. There is limited data available on the natural history and HPV-related diseases in the genital tract in men, although studies are ongoing. Efficacy of HPV vaccines in the prevention of HPV infection and disease among men also remains unknown. Among HPV DNA positive ano-genital cancer cases, HPV-16 is the most frequently found followed distantly by HPV-18. In benign HPV-related diseases such as genital warts or recurrent respiratory papillomatosis HPV-6 and 11, the two most frequent non-oncogenic types, are the predominant types detected. Oncogenic types are rarely detected. In this article we summarize and review studies describing the natural history of HPV infections among men and its impact on HPV related disease in women. We summarize the evidence linking HPV in the epidemiology and etiology of cancers of the vulva, vagina, anus and oropharynx and present recent estimates of the burden of and HPV type distribution in genital warts and in cases of HPV infection of the airways.

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Reliability of sample collection and laboratory testing for HPV Detection in Men

Cited by 39 publications

References 32 publications

Smoking and Human Papillomavirus (HPV) Infection in the HPV in Men (HIM) Study

Smoking and Human Papillomavirus (HPV) Infection in the HPV in Men (HIM) Study

Circumcision and sexual behavior: Factors independently associated with human papillomavirus detection among men in the HIM study

Epidemiology of Human Papillomavirus Infection in Men, Cancers other than Cervical and Benign Conditions

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