Smoking and Human Papillomavirus (HPV) Infection in the HPV in Men (HIM) Study

Schabath, Matthew B.; Villa, Luisa L.; Lazcano‐Ponce, Eduardo; Salmerón, Jorge; Quiterio, Manuel; Giuliano, Anna R.

doi:10.1158/1055-9965.epi-11-0591

Cited by 65 publications

(61 citation statements)

References 34 publications

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“…We also found that current smokers had a significantly elevated risk of nononcogenic HPV infection, which was in keeping with the HIM study (17). A potential mechanism is that smoking may increase the HPV viral load by weakening the cellular immune response (37). To investigate the possibility that the lifetime number of sexual partners acted as a confounder within the association between smoking and nononcogenic HPV incidence, stratification analysis by the lifetime sexual partner group was conducted.…”

Section: Discussionsupporting

confidence: 85%

Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China

Liu

Zhang

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The natural history of human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men.Methods: A total of 1,286 men ages 25 to 65 years from rural China were enrolled during 2009-2010 and their genital HPV infection status was assessed biannually for up to seven visits using PCR and sequencing methods. Prevalence analysis was performed among men with at least one valid HPV result (N ¼ 1,279) and men with at least two consecutive HPV results (N ¼ 1,059) were included in incidence and clearance analyses (median follow-up time, 31.8 months; interquartile range, 15.4-37.9 months).Results: The prevalence and incidence of any HPV type, oncogenic, and nononcogenic HPV were 17.8%, 6.4%, 12.4%, and 14.6, 4.9, 10.8 per 1,000 person months, respectively. The median duration of infection with any HPV type, oncogenic, and nononcogenic HPV was 11.5, 6.8, and 11.5 months, respectively. The number of lifetime sexual partners was consistently associated with increased risk of prevalent and incident infection of HPV. Men ages 25 to 50 years had a higher incidence and longer duration of HPV infection than older men (51-65 years).Conclusions and Impact: This epidemiologic investigation provides basic information of genital HPV infection among the Chinese male population; these data are crucial for the consideration of primary strategies against HPV-related carcinoma in the Chinese male and female population. Cancer Epidemiol Biomarkers Prev; 23(12); 2857-65. Ó2014 AACR.

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Section: Discussionsupporting

confidence: 85%

Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China

Liu

Zhang

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Previous studies in both men and women have shown that cigarette smoking is associated with HPV prevalence (27, 28), incidence (29), and persistence (30). We found significant point estimates for the association between alcohol consumption and HPV infection among never smokers and borderline significant associations among current smokers.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study

et al. 2014

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Objectives Moderate alcohol consumption can impair host defense against viral infections. The objective of this cross-sectional analysis was to assess the association between alcohol intake and prevalent HPV infection among U.S. men enrolled in the HIM (HPV in Men) Study utilizing quantitative alcohol intake measured from a food frequency questionnaire. Methods The HIM study is a prospective, multinational study of the natural history of HPV infection. For this report we restricted our analyses to men from the US cohort (No. = 1,313). Samples from the corona of glans penis, penile shaft, and scrotum were combined for HPV DNA testing. Self-reported alcohol intake was quantified by grams of alcohol intake per day. Multivariable prevalence ratios (mPR) were used to assess the association between alcohol intake and HPV infections. Results Prevalent infections were significantly higher among men in the highest quartile of alcohol intake and multivariable models revealed that the highest quartile of alcohol intake was associated with significantly increased risks for any- (mPR=1.13; 95% CI 1.00–1.27) and oncogenic (mPR=1.35; 95% CI 1.08–1.68) HPV types. The fourth quartile of alcohol intake was associated with elevated risks for prevalent HPV infection across all strata of number of sexual partners and among never- and current smokers, but not among former smokers. Conclusions These results demonstrate that high intake of alcohol is associated with an increased risk for prevalent HPV infections among men. The biological role that alcohol plays in genital HPV infection remains understudied and limited epidemiologic data exist especially among men.

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“…Increased metaplastic activity in the cervix during adolescence and its decline after menopause implica earlier age at sexual debut as a risk factor for HPV infection. Other factors related to HPV infection or persistence include young age, the socioeconomic status, multiparity, male circumcision, condom use, oral contraceptive use, smoking, immune suppression, viral load, and certain genetic polymorphisms 26, 91, 73, 89, 34, 32, 71, 83, 86, 30 40, 62, 82, 69, 68, 11, 67, 35, 61 90, 72, 66, 54, 6, 84, 59, 43 44, 31, 42, 45, 74, 33, 81, 70 51, 58, 53, 56 52 18 16 in the human leukocyte antigen system (Moscicki et al, 2001;Palefsky et al, 2001;Maciag et al, 2002;Schlecht et al, 2002;Richardson et al, 2003;Winer et al, 2003;Baldwin et al, 2004;Baseman and Koutsky, 2005;Cotton et al, 2007;Goodman et al, 2008;Tobian et al, 2009;Tobian et al, 2010;Marks et al, 2011;Bahmanyar et al, 2012;Emeka et al, 2012;Liao et al, 2012;Repp et al, 2012;Schabath et al, 2012;Teixeira et al, 2012;Zhang et al, 2012).…”

Section: Epidemiology Of Human Papillomavirus Infectionsmentioning

confidence: 99%

“…However, in case of men, limited data exist on the association between HPV infection and smoking. In a multinational prospective study observing the association between smoking and HPV infection, Schabath et al (2012) found that current smoking was associated with an increased risk of any HPV infection as well as an oncogenic HPV infection. However, the association between smoking and any HPV infection and oncogenic HPV infection was only evident among men reporting fewer lifetime sexual partners.…”

Section: Epidemiology Of Human Papillomavirus Infectionsmentioning

confidence: 99%

Review of the current knowledge on the epidemiology, pathogenesis, and prevention of human papillomavirus infection

Asiaf

Ahmad

Mohammad

et al. 2014

European Journal of Cancer Prevention

100

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Human papillomavirus (HPV) infection is a central and necessary, although not sufficient, cause of cervical cancer. Besides HPV, the additional multiple risk factors related with the onset of cervical cancer are early-age sexual activities; high number of sexual partners, which is the most salient risk factor; suppression and alteration of the immune status; long-term use of oral contraceptives; and other hormonal influences. The tumor-suppressor proteins p53 and pRb are degraded and destabilized through ubiquitination by viral oncoproteins E6 and E7. Over 95% of cervical cancer cases worldwide test positive for oncogenic HPV DNA. Although cervical screening procedures have been successful in reducing the disease burden associated with HPV infection because of lack of resources or inadequate infrastructure many countries have failed to reduce cervical cancer mortality. Therefore, prevention may be a valuable strategy for reducing the economic and disease burden of HPV infection. At present, two successful prophylactic HPV vaccines are available, quadrivalent (HPV16/18/6/11) 'Gardasil' and bivalent (HPV16/18) 'Cervarix' for vaccinating young adolescent girls at or before the onset of puberty. Recent data indicate that vaccination prevents the development of cervical lesions in women who have not already acquired the vaccine-specific HPV types. Moreover, several therapeutic vaccines that are protein/peptide-based, DNA-based, or cell-based are in clinical trials but are yet to establish their efficacy; these vaccines are likely to provide important future health benefits. The therapeutic vaccination mode of prevention is a promising area of research, as revealed in preclinical trials; however, clinical trials based on large populations are warranted before reaching a valid conclusion. This review summarizes the studies on the epidemiology of HPV infection, the pathogenesis of viral oncoproteins in the oncogenesis of cervical cancer, the economic and health burden of HPV-related diseases, and, finally, focuses on the results of recent clinical vaccination trials.

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Smoking and Human Papillomavirus (HPV) Infection in the HPV in Men (HIM) Study

Cited by 65 publications

References 34 publications

Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China

Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China

Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study

Review of the current knowledge on the epidemiology, pathogenesis, and prevention of human papillomavirus infection

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