Relevance of vitamin D in reproduction

Luk, Janelle; Torrealday, Saioa; Perry, Genevieve Neal; Pal, Lubna

doi:10.1093/humrep/des248

Cited by 151 publications

(116 citation statements)

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“…The relationship between VitD status and reproductive disorders in females is mainly associative, with no direct causative role established (Luk et al 2012). In addition, minimal progress has been made in understanding the participation of VitD-VDR Figure 3 Molecular overview of VitD action in cells from the reproductive system.…”

Section: Molecular Mechanistic Studies In Female Reproductive Cellsmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.Reproduction (2017) 153 R29-R42

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Section: Molecular Mechanistic Studies In Female Reproductive Cellsmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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“…Vitamin D is a steroid substance plays a key role in calcium and phosphorus metabolism [1][2][3]. Its main actions include intestinal calcium absorption and renal calcium reabsorption, as well as a direct effect on chondrocyte and osteoblast differentiation and subsequent bone formation [3].…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D and anti- mullerian hormone levels in Iraqi infertile women at Baghdad city

Abdul‐Rasheed

Ali

Abdulrasul

2015

IJBAS

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Background: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility, a growing body of literature suggests that environmental & lifestyle factors play an important role. Recent studies suggest that vitamin D may play a role in human reproduction. Exact mechanisms whereby vitamin D may participate in the regulation of reproductive physiology remains far from clear. Objective: To validate the potential of vitamin D as a biomarker for prediction of female infertility and to study the correlation between vitamin D and Anti-Mullerian hormone. Methods: A case-control study was conducted at Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Al-Kadhmiya, Baghdad, Iraq from June 2013 till July 2014. Seventy three subjects were enrolled in this study. Thirty five primary infertile women with mean age (25.4± 4.91 years), and thirty eight agematched apparently healthy women as controls with mean age (27.3±3.72 years). Fasting blood samples were collected in the morning at 8:00 am from all participants. Vitamin D was measured by high-performance liquid chromatography technique and Anti-Mullerian hormone was measured by enzyme-linked immunosorbent assay. Results: Vitamin D levels was significantly decreased in the infertile women group compared with fertile control group (35.38±5.83 ng/ mL) versus (49.99±12.90 ng/ mL) respectively. Vitamin D correlated significantly (r = +0.86; p ≤ 0.05) with anti-mullerian hormone and anti-mullerian hormone shows a significant negative correlation with body mass index (r = -0.78; p ≤ 0.05). Conclusion: A novel relationship was found between circulating Anti-Mullerian hormone and vitamin D in plasma samples of infertile women.

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“…1 More recently, vitamin D metabolizing enzymes are described in the human testis, the ejaculatory tract, mature spermatozoa, and in Leydig cells. 2 The expression levels of vitamin D receptors and CYP24A1 in human spermatozoa serve as positive predictive markers of semen quality, and VDR mediates a non-genomic increase in intracellular calcium concentration that induces sperm motility. VDR elicits a rapid increase in intracellular Ca Results from human association studies are in line with those in animal models, as men with vitamin sufficiency have a higher percentage of motile spermatozoa than men with vitamin deficiency.…”

Section: Vitamin D and Male Infertilitymentioning

confidence: 99%

“…2 Interestingly, another study published in November 2009 confirmed that human sperm contain a vitamin D receptor. 3 Analysis indicated that vitamin D is produced locally in the sperm, which suggests that vitamin D may be involved in the signaling between cells in the reproductive system.…”

Section: Clinical Efficiency Of Vitamin D In Female Infertilitymentioning

confidence: 99%