Release Profile of Gentamicin Sulfate from Polylactide-co-Polycaprolactone Electrospun Nanofiber Matrices

Abstract

The advent and growth of resistance phenomena to antibiotics has reached critical levels, invalidating the action of a majority of antibiotic drugs currently used in the clinical field. Several innovative techniques, such as the nanotechnology, can be applied for creating innovative drug delivery systems designed to modify drug release itself and/or drug administration route; moreover, they have proved suitable for overcoming the phenomenon of antibiotic resistance. Electrospun nanofibers, due to their useful structural properties, are showing promising results as antibiotic release devices for preventing bacteria biofilm formation after surgical operation and for limiting resistance phenomena. In this work gentamicin sulfate (GS) was loaded into polylactide-co-polycaprolactone (PLA-PCL) electrospun nanofibers; quantification and in vitro drug release profiles in static and dynamic conditions were investigated; GS kinetic release from nanofibers was studied using mathematical models. A preliminary microbiological test was carried out towards Staphylococcus aureus and Escherichia coli bacteria.

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

“…Antibiotic-loaded electrospun matrices allow us to reach high antibiotic concentrations at the site of infection, avoiding high system concentrations and related side effects. Moreover, the administration frequency is reduced and, consequently, patient compliance enhanced [ 113 ].…”

Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

“…[81] As the effectiveness of drug release has dependence with its release mechanism that can be including can be a mechanism of swelling, diffusion, desorption, and/or degradation of the matrix [6,13] the release mechanism of P 4 -loaded CA nanofibers was also evaluated. As the Higuchi and Zero-order kinetic models are commonly used to describe drug release profiles, [82,83] including to study the release mechanism in polymer nanofibers mats structures, [84,85] these models were chosen to analyze the data in the first release stage, that is, the burst release. Comparing the results presented in Figure 7A,B it was concluded that Higuchi kinetic model was the model that best suits the behavior of the samples with 4, 6, 8, and 10% w/w P 4 samples.…”

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

“…In the study [13], Vahedi et al have revealed that the flow conditions influence the release profile by acting on the penetration depth of the fluid. Many other studies have also revealed this effect [24][25][26]. Depending on the property of degradation, mechanisms of release can be distinct.…”