Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

Soares, Gabriella Onila do Nascimento; Machado, Raíssa Ribeiro Lima; Diniz, Mariana Mendonça; Silva, Aline Bruna da

doi:10.1002/pen.25549

Cited by 12 publications

(6 citation statements)

References 75 publications

(145 reference statements)

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“…According to previous studies, the content of 10% w/w (pheromone weight to PHB weight) facilitated the homogenous dispersion of TDDA within PHB 18 . The observed increase in fiber diameter upon TDDA loading further supports its effective distribution within the 5‐PHB‐TDDA fiber 15,30,31 . The appearance of branched substructures in 7‐PHB‐TDDA may be a consequence of the inhomogeneity of the spinning solution affecting the fiber morphology.…”

Section: Discussionsupporting

confidence: 55%

“…18 The observed increase in fiber diameter upon TDDA loading further supports its effective distribution within the 5-PHB-TDDA fiber. 15,30,31 The appearance of branched substructures in 7-PHB-TDDA may be a consequence of the inhomogeneity of the spinning solution affecting the fiber morphology. It is evident that molecular entanglements exhibit greater strength in solutions with high concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Biodegradable electrospun fibers as sustained‐release carriers of insect pheromones for field trapping of Spodoptera litura (Lepidoptera: Noctuidae)

Shangguan,

Mei,

Chen

et al. 2023

Pest Management Science

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BACKGROUNDInsect pheromones are highly effective and environmentally friendly, and are widely used in the monitoring and trapping of pests. However, many researchers have found that various factors such as ultraviolet light and temperature in the field environment can accelerate the volatilization of pheromones, thus affecting the actual control effect. In recent years, electrospinning technology has demonstrated remarkable potential in the preparation of sustained carriers. Moreover, the utilization of biodegradable materials in electrospinning presents a promising avenue for the advancement of eco‐friendly carriers.RESULTSIn this study, homogeneous and defect‐free pheromone carriers were obtained by electrospinning using fully biodegradable polyhydroxybutyrate materials and pheromones of Spodoptera litura. The electrospun fibers with porous structure could continuously release pheromone (the longest can be ≤80 days). They also had low light transmission, hydrophobic protection. More importantly, the pheromone‐loaded electrospun fiber carriers showed stable release and good trapping effect in the field. They could trap pests for at least 7 weeks in the field environment without other light stabilizers added.CONCLUSIONSustained‐release carriers constructed by electrospinning and green materials could improve the efficacy of pheromones and ensure environmental friendliness, and provided a tool for the management of S. litura and other pests and sustainable development of agricultural. © 2023 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Biodegradable electrospun fibers as sustained‐release carriers of insect pheromones for field trapping of Spodoptera litura (Lepidoptera: Noctuidae)

Shangguan,

Mei,

Chen

et al. 2023

Pest Management Science

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“…With respect to the n values of CA-AS005 and CA-AS01 – for the corresponding geometries – we can conclude that both of these samples release the incorporated drug following a typical Fickian diffusion. Interestingly, CA-AS1 and CA-AS5 samples demonstrated lower n values suggesting that the drug release is controlled also by a Fickian diffusion, but in a more sustained manner [ 34 , 35 ]. This can be seen in Fig.…”

Section: Discussionmentioning

confidence: 99%

Electrospun wound dressings containing bioactive natural products: physico-chemical characterization and biological assessment

et al. 2021

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Background Current research on skin tissue engineering has been focusing on novel therapies for the effective management of chronic wounds. A critical aspect is to develop matrices that promote growth and uniform distribution of cells across the wound area, and at the same time offer protection, as well as deliver drugs that help wound healing and tissue regeneration. In this context, we aimed at developing electrospun scaffolds that could serve as carriers for the bioactive natural products alkannin and shikonin (A/S). Methods A series of polymeric nanofibers composed of cellulose acetate (CA) or poly(ε-caprolactone) (PCL) and varying ratios of a mixture of A/S derivatives, has been successfully fabricated and their physico-chemical and biological properties have been explored. Results Scanning electron microscopy revealed a uniform and bead-free morphology for CA scaffolds, while for PCL beads along the fibers were observed. The average diameters for all nanofibers ranged between 361 ± 47 and 487 ± 88 nm. During the assessment of physicochemical characteristics, CA fiber mats exhibited a more favored profile, while the assessment of the biological properties of the scaffolds showed that CA samples containing A/S mixture up to 1 wt.% achieved to facilitate attachment, survival and migration of Hs27 fibroblasts. With respect to the antimicrobial properties of the scaffolds, higher drug-loaded (1 and 5 wt.%) samples succeeded in inhibiting the growth of Staphylococcus epidermidis and S. aureus around the edges of the fiber mats. Finally, carrying out a structure-activity relationship study regarding the biological activities (fibroblast toxicity/proliferation and antibacterial activity) of pure A/S compounds – present in the A/S mixture – we concluded that A/S ester derivatives and the dimeric A/S augmented cell proliferation after 3 days, whereas shikonin proved to be toxic at 500 nM and 1 μM and alkannin only at 1 μM. Additionally, alkannin, shikonin and acetyl-shikonin showed more pronounced antibacterial properties than the other esters, the dimeric derivative and the A/S mixture itself. Conclusions Taken together, these findings indicate that embedding A/S derivatives into CA nanofibers might be an advantageous drug delivery system that could also serve as a potential candidate for biomedical applications in the field of skin tissue engineering.

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“…Nanoremediation is a fast and effective technology that leverages engineered or biogenic‐product nanomaterials in treatment processes 10 . Numerous studies have been conducted on nanoremediation using different types of nanomaterials, including carbon, silica, metal, and polymers 11,12 . In addition, studies involving nanomaterials have produced modified structures like microorganism‐integrated materials.…”

Section: Introductionmentioning

confidence: 99%

Nanoremediation of toxic dyes using a bacterial consortium immobilized on cellulose acetate nanofiber mats

Erkoç,

Tüzün,

Korkmaz

et al. 2023

Polymer Engineering & Sci

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Stenotrophomonas maltophilia and Ochrobactrum sp. demonstrated the highest rates of dye bioremediation. The trials were performed at pH 8, which resulted in the highest bioremediation rate of 64.6% in media containing 21.2 mg L−1 dye. As the dye concentration increased, the pollutant removal decreased, with the maximum bioremoval rate of 70.3%. The removal capacity was increased with an increase in biomass concentration; the highest yield of 91.3% was obtained in media containing 14.2 mg L−1 dye and 12% (v/v) biomass. In nanoremediation studies, the bacterial consortium was immobilized on cellulose acetate nanofiber mats (CA‐NFM). Scanning electron microscopic micrographs showed that bead‐free nanofiber mats were effective in immobilizing bacterial cells. Moreover, nanofiber structures were capable of supporting exopolysaccharides formation, as confirmed by Fourier transform ınfrared spectroscopy. The bacterial consortium immobilized on CA‐NFM showed a maximum bioremoval rate of 56.5%. Reusability tests demonstrated that the consortium immobilized CA‐NFM could be used at least five times. Furthermore, after leaving the mat for 1 month at 4°C, it was still usable, and the removal efficiency was found to be 45.4%. Based on our findings, bacteria immobilized on CA‐NFM have the potential to be used as highly effective and versatile nanobiotechnological biological sorbents in the treatment of wastewater containing dyes.Highlights Stenotrophomonas maltophilia and Ochrobactrum sp. were used as a bacterial consortium. Bacterial consortium immobilized on cellulose acetate nanofiber mats (CA‐NFM) was tested. EPS production by the consortium was confirmed by Fourier transform ınfrared spectroscopy analysis. CA‐NFM could be used at least five times.

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Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

Cited by 12 publications

References 75 publications

Biodegradable electrospun fibers as sustained‐release carriers of insect pheromones for field trapping of Spodoptera litura (Lepidoptera: Noctuidae)

Biodegradable electrospun fibers as sustained‐release carriers of insect pheromones for field trapping of Spodoptera litura (Lepidoptera: Noctuidae)

Electrospun wound dressings containing bioactive natural products: physico-chemical characterization and biological assessment

Nanoremediation of toxic dyes using a bacterial consortium immobilized on cellulose acetate nanofiber mats

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