Release of Drugs from Polymeric Hydrogels

Abstract

Hydrogels were prepared from 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate as cross-linking agent. Two different polymerization techniques were followed, namely bulk polymerization initiated by dibenzoyl peroxide and solution polymerization, in water, using a redox initiator system. Differences in the water desorption from swollen samples between the two types of the above products were recorded and attributed to the fact that those hydrogels were obtained in glassy or rubbery state, according to the polymerization technique. Also, the delivery of salicylic acid from samples of the above types was studied, and a faster release with higher ultimate delivery was displayed by the solution polymerization hydrogels.

Preparation and characterization of novel pH‐sensitive binary grafted polymeric blends of gelatin and poly(vinyl alcohol): Water sorption and blood compatibility study

“…The high water intake of hydrogels allows easier extraction of undesirable reaction byproducts before implantation and easy penetration of small molecules such as water, electrolytes, and metabolites into them in vivo . Some typical biomedical applications of hydrogels include the manufacturing of contact lenses, wound dressings,4 controlled drug release systems,5 artificial implants,6 biosensors,7 and surgical prostheses 8…”

Blood protein adsorption onto a polymeric biomaterial of polyethylene glycol and poly[(2‐hydroxyethyl methacrylate)‐co‐acrylonitrile] and evaluation of in vitro blood compatibility

“…The adsorbed protein layer can further mediate additional biological responses, such as cell attachment and activation, and can create unpredicted perturbations to device operation 2. The adsorption of proteins on polymers includes the following applications: artificial tissues and organs, drug‐delivery systems, biosensors, solid‐phase immunoassays, immunomagnetic cell separations and immobilized enzymes 3–7…”

Modulation of in Vitro Release of Crystal Violet From a Binary Polymer Hydrogel System

“…[1] Only some drug delivery systems can fulfill the later requirement, although, some repository preparations can remain therapeutically effective up to several days even without exhibiting zero-order kinetic release behavior. [3,4] Hydrogels as biomaterials are favored due to the possibility of an interchange between the water they retain and body fluid, which is associated with biocompatibility. Hydrogels are very versatile materials.…”