Modulation of in Vitro Release of Crystal Violet From a Binary Polymer Hydrogel System

Abstract

A macromolecular vehicle entrapping crystal violet (CV) as a model drug was developed by crosslink polymerization of acrylamide and styrene in the presence of a hydrophilic polymer poly(vinyl alcohol). The loaded polymer matrix was monitored for the controlled release of the crystal violet by a spectrophotometric method. The dynamics of the release process was investigated as a function of the composition of the gel and pH of the release medium. The mechanism of the release process was examined kinetically in terms of the quantitative parameters such as the diffusional exponent n and diffusion constant D evaluated using the Ficks equations.

Preparation and characterization of nanostructured and high transparent hydrogel films with pH sensitivity and application

“…The equation of M t /M 1 ¼ kt n was used to study the release kinetics, 32 where M t /M 1 represented the drug release fraction at time t, k was a constant incorporating the structural and geometric characteristics of the matrix tablets, and n was the release exponent, indicative of the drug release mechanism. When n ¼ 0.5, it was Fickian release; n ¼ 1, it was zero order release; 1 > n > 0.5, it was non-Fickian release or anomalous transport of drug (diffusion and polymer relaxation simultaneously make effect).…”

Self assembled hydrophobic nanoclusters of poly(methyl methacrylate) embedded into polyvinyl alcohol based hydrophilic matrix: Preparation and water sorption study

“…Their sensitive response to external stimuli such as pH,11–13 temperature,14–16 ionic strength,17 magnetic field,18–19 electric field,20–22 ultraviolet light,23 etc. and internal stimuli like chemical architecture,24–25 initiators conditions,26 etc. enable them to deserve as a potential candidate in biomaterial applications.…”